A5041758591- Ubiquitin and proteasome pathways
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Developmental Biology and Gene Regulation
- Circadian rhythm and melatonin
- Zebrafish Biomedical Research Applications
Princeton University
2021-2023
WuXi AppTec (China)
2022
Some Ciona neurons show transcriptional similarities to the mouse hypothalamus, suggesting that it predates vertebrates.
Thalidomide has a dark history as teratogen, but in recent years, its derivates have been shown to function potent chemotherapeutic agents. These drugs bind cereblon (CRBN), the substrate receptor of an E3 ubiquitin ligase complex, and modify degradation targets. Despite these insights, remarkably little is known about normal development. Here, we employ Ciona , simple invertebrate chordate, identify endogenous Crbn In Ciona, specifically expressed developing muscles during tail elongation...
ABSTRACT Thalidomide has a dark history as teratogen, but in recent years it been shown to function chemotherapeutic agent. binds cereblon, component of E3 ubiquitin ligase complex and modifies its degradation targets. Despite these insights, remarkably little is known about the normal cereblon development. Here, we employ simple proto-vertebrate model, Ciona intestinalis , address this question. We observed “hotspot” Crbn expression developing tail muscles identify enhancer containing both...