A5045829203- Primate Behavior and Ecology
- Animal Behavior and Reproduction
- Wildlife Ecology and Conservation
- Animal Vocal Communication and Behavior
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Safe Handling of Antineoplastic Drugs
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Economic and Financial Impacts of Cancer
- Animal Behavior and Welfare Studies
- Biosimilars and Bioanalytical Methods
- Ovarian function and disorders
- Multiple and Secondary Primary Cancers
- Botany and Plant Ecology Studies
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Reproductive biology and impacts on aquatic species
- Agriculture and Biological Studies
- Cardiac tumors and thrombi
- Cardiac Ischemia and Reperfusion
- Neuroendocrine regulation and behavior
- Amphibian and Reptile Biology
Saint Louis Zoo
2018-2024
Washington University in St. Louis
2014-2023
Association of Zoos and Aquariums
2023
CHI Health St. Francis
2017-2018
San Francisco State University
2010
California Academy of Sciences
2010
Aurora St. Luke's Medical Center
2004
Wisconsin Heart Hospital
2003
University Hospitals of Cleveland
2000
Case Western Reserve University
2000
Little is known about genetic variation in the 6-8 subspecies of Colobus angolensis, currently distinguished by pelage differences. We present a comparative analysis one these subspecies, C. a. palliatus, Kenya and Tanzania that assesses evolutionary relationships patterns mitochondrial diversity 103 individuals across its geographic range. Fecal samples from approximately 156 were collected four localities: (1) Diani Forest, Kenya; (2) Shimoni, (3) Udzungwa Mountains National Park, Eastern...
Western lowland gorillas ( Gorilla gorilla ) in zoos are housed family or bachelor groups to maximize social opportunities. While wild transient, all‐male may be maintained for many years. Captive need carefully monitored, particularly during periods of demographic transition, due the possibility escalating aggression. We examined behavioral changes a group at Saint Louis Zoo following two significant alterations composition: (1) introduction immature related males 2011 and (2) death...
Abstract Melengestrol acetate (MGA) implants are a progestin‐based reversible contraceptive used to manage fertility in animals. MGA recommended for replacement every 2 years; however, reproduction may be suppressed longer if not removed. In this study, we investigated whether the probability of reproducing (pR) differed among nonimplanted females, females with removed, and whose were addition, since implant loss hamadryas baboons is concern, explored female age, institution, placement year,...
Purpose Increasing new cancer cases and approval of effective but expensive drugs extending survival have led to unsustainable care costs. Potential cost savings by a hypothetical dose down-rounding project monoclonal antibodies at community-based center is presented. Methods From October 2014 through 2015, metastatic patients receiving CHI-Health St Francis Cancer Treatment Center in Grand Island, Nebraska, were identified electronic health records. A total 11 different types that...
Abstract Ecological niche models can be useful for clarifying relationships between environmental factors and a species’ geographic distribution. In this study, we use presence‐only data layers to create an ecological model better understand the distribution of East African Angolan black white colobus monkey, Colobus angolensis palliatus , assess whether supports considering population as two separate subspecies, sharpei C. a. . We found range predicted suitable habitat currently classified...
Thrombin (Thromb), activated as part of the clotting cascade, dilates conduit arteries through an endothelial pertussis toxin (PTX)-sensitive G-protein receptor and releases nitric oxide (NO). Thromb also acts on downstream microvessels. Therefore, we examined whether human coronary arterioles (HCA). HCA from right atrial appendages were constricted by 30–50% with endothelin-1. Dilation to (10 −4 –1 U/ml) was assessed before after inhibitors videomicroscopy. There no tachyphylaxis dilation...
The Association of Zoos and Aquariums Reproductive Management Center (RMC) in the US European Aquaria Group (RMG) Europe monitor efficacy contraceptive products participating institutions use those results to inform recommendations. This study used joint RMC-RMG Contraception Database analyze deslorelin implants (Suprelorin®), a wide range mammalian taxa. More recently its has increased birds some reptiles fish. Deslorelin, gonadotropin-releasing hormone (GnRH) agonist, stimulates...
Abstract Across zoo's accredited by the Association of Zoos and Aquariums (AZA), species are typically managed as a single population to retain 90% founding members' gene diversity. Often, little is known about specific geographic origins founders or how representative ex situ population's genetic diversity wild population. This study uses mitochondrial DNA (mtDNA) sequencing investigate haplotype female founder origin AZA‐managed Angolan colobus ( Colobus angolensis ) monkey We obtained...
Abstract Whether the Colobus angolensis that reside in fragmented forests eastern Kenya and Tanzania represent one subspecies or two has been debated for 50 years. Morphological more recent genetic ecological studies suggest these populations subspecies, C. a. palliatus sharpei . However, their distribution of mitochondrial variation remains unresolved since study only characterized four at range ends. Therefore, we five area hypothesized divide. We identified eight new haplotypes which,...
Abstract Melengestrol acetate (MGA) implants are progestin‐based reversible contraceptives used to manage fertility in zoo populations. Although it is recommended that MGA should be replaced every 2 years, the duration of efficacy has not been systematically evaluated most species. Anecdotal reports for Old World monkeys indicate reproduction may suppressed longer if implant removed. This study uses Guereza colobus monkey ( Colobus guereza ) as a model species examine effects on reproductive...
Abstract Due to their potential impact on population growth, many studies have investigated factors affecting infant survival in mammal populations under human care. Here we used more than 30 years of Association Zoos and Aquariums (AZA) studbook data contraception from the AZA Reproductive Management Center, along with logistic regression models, investigate which affect four Eulemur species managed as Species Survival Plans® AZA. Across species, 1 month ranged 65% 78%. Previous experience...
The long-term sustainability of ex situ animal populations requires coordination across facilities through cooperative breeding programs. Here, we investigate the reasons for inconsistent reproductive success in zoo-based North American Asian small-clawed otter (ASCO; Aonyx cinereus) population. Reproductive viability analysis (RVA) was used to identify which characteristics ASCOs pairs were most predictive success. RVA identified pair type, contraception history, and age as significant...
6616 Background: Increasing new cancer cases and approval of expensive drugs extending survival has led to unsustainable care costs. Potential cost savings by a dose rounding practice for mABs is presented. Methods: Using EHR, Oct 2014 - 2015, metastatic patients receiving at CHI-Health St Francis in Grand Island Nebraska were identified. Trastuzumab, ofatumumab, obinutuzumab did not require excluded. Available vial size(s) cost/mg (per acquisition costs) each mAB recorded. Costs actual...
e18040 Background: Patient navigation is an intervention to improve cancer outcomes by facilitating timely access care. Few comparative data exist about the effects of nurse in core metrics (CNM) a community oncology setting. Methods: During one-year period community-based/patient entry-point program, CNMs newly diagnosed breast and non-breast patients were collected compared that demographic tumor characteristics-matched control group prior navigation. Electronic medical records registry...
e15064 Background: Immune-checkpoint inhibitor (ICI) therapy related thyroid function test (TFT) abnormalities are not uncommon. No well-established guidelines on the type, frequency, and duration of monitoring TFTs exist in this setting. We retrospectively evaluated practice patterns TFT utilization for ICI treated cancer patients (pts) our community based program. Methods: Review records pts receiving ICIs (Ipilimumab (I), Nivolumab(N) +/- Ipilimumab, Pembrolizumab(P), Atezolizumab(A)) was...
The off pump technique demonstrated here for the AFx Flex 4™ microwave antenna is applicable any energy source that uses a narrow flexible ablation probe shielded on its outside surface. Microwave, diode laser, and high-intensity focused ultrasound are examples of such tools either now available or under development. Left atrial appendage (LAA) thrombus must be excluded before epicardial ablation. Transesophageal echo (TEE) excludes obvious thrombi, but even when negative, gentle surface...