A5068457307- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- Biochemical Acid Research Studies
- Alcohol Consumption and Health Effects
- Medicinal Plants and Bioactive Compounds
- Ginseng Biological Effects and Applications
- Polysaccharides and Plant Cell Walls
- Saffron Plant Research Studies
- Folate and B Vitamins Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Reproductive System and Pregnancy
- Autophagy in Disease and Therapy
- Flavonoids in Medical Research
- Chronic Kidney Disease and Diabetes
- Renin-Angiotensin System Studies
- Liver Disease Diagnosis and Treatment
Shanghai University of Traditional Chinese Medicine
2013-2025
Nephrotic syndrome (NS) is a common glomerular ailment caused by various factors and ranks as the second most frequently seen kidney disease. The study aims to investigate potential therapeutic mechanism of cinnamaldehyde (CA) intervention in NS utilizing computational pharmacology. Genes linked were gathered from databases then used construct PPI network, which node importance values (Nim) calculated an optimized algorithm. Functional enrichment analyses performed build pathway network for...
Chaihu Shugan Powder (CHSGP) has significant clinical efficacy in the treatment of functional dyspepsia (FD), but specific mechanism requires further study. The aim this study was to investigate therapeutic effect CHSGP on FD rats and underlying interstitial cells cajal (ICC) mitophagy. tail-clamping stimulation method utilized establish an rat model vivo. Gastric emptying rate small intestinal propulsion test, H&E staining, Immunohistochemistry were conducted evaluate effects rats. In...
Background: Guizhi has the pharmacological activity of anti-inflammatory. However, effect mechanism against nephrotic syndrome (NS) remains unclear. A network approach with experimental verification in vitro and vivo was performed to investigate potential mechanisms treat NS. Methods: Active compounds targets Guizhi, as well related NS were obtained from public databases. The intersecting through Venny 2.1.0. key signaling pathways determined by protein-protein interaction (PPI), genes...
Nephrotic syndrome (NS) is a common glomerular disease caused by variety of causes and the second most kidney disease. Guizhi key drug Wulingsan in treatment NS. However, action mechanism remains unclear. In this study, network pharmacology molecular docking were used to explore underlying treating NS.The active components targets screened Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP), Hitpick, SEA, Swiss Target Prediction database. The related NS...
Abstract Fan Hong Hua (李时珍 saffron) is a natural product that has long been used in food and dye industries fortreating various disorders. Saffron history of applications traditional Chinese medicine, following its introduction to China 1979. According the theory saffron sweet, slightly cold nature enters heart liver meridians. Moreover, this spice can invigorate blood circulation, eliminate stasis, cool heat toxins. treat asthma, phlegm, insomnia, Alzheimer's disease, depression, fright,...
Objective. Cinnamaldehyde (CA) is the main active component of Guizhi (Cinnamomi ramulus) to ameliorate adriamycin- (ADR-) induced proteinuria in rats. However, underlying mechanism CA against remains unclear. The aim this study was investigate action mechanisms treat proteinuria. Methods. 13 rats were randomly selected from 78 SD as control group, and other injected with ADR (3 mg/kg/time) twice through tail vein on day 1 8 for modeling. After modeling, divided into 5 groups follows: ADR+CA...