A5101488123- Cancer Cells and Metastasis
- Animal Genetics and Reproduction
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- TGF-β signaling in diseases
- Advanced biosensing and bioanalysis techniques
- Peripheral Artery Disease Management
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Diabetes and associated disorders
- Ocular Oncology and Treatments
- Venous Thromboembolism Diagnosis and Management
- Mast cells and histamine
- Microtubule and mitosis dynamics
- Monoclonal and Polyclonal Antibodies Research
- Plasma Applications and Diagnostics
- Animal Nutrition and Health
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
University of Michigan
2020-2024
Cancer Research Center
2014-2018
University of California, San Francisco
2014-2018
University of Toronto
1994-2016
Wayne State University
2016
University Health Network
2016
Hospital Universitari Germans Trias i Pujol
2016
Mount Sinai Beth Israel
2016
Cancer Research Institute
2014-2015
University of San Francisco
2014
Aptamer modified gold nanoparticles target malignant cells. Anti-cancer therapeutics are released after cleavage of a self-immolative linker by intracellular triggers.
// Christian Posch 1, 2, 3 , Martina Sanlorenzo 4 Jeffrey Ma 2 Sarasa T. Kim Mitchell Zekhtser and Susana Ortiz-Urda 1 Technical University of Munich, Department Dermatology Allergy, 80802 Germany California San Francisco, Dermatology, Mt. Zion Cancer Research Center, 94115 USA Faculty Medicine, Sigmund Freud University, 1020, Vienna, Austria Institute Research, Medical 1090 Correspondence to: Posch, email: cposch81@gmail.com Keywords: NRAS; CDK4; BRAF; MEK; melanoma Received: August 01,...
Antibodies to programmed cell death protein1 (anti-PD-1) have become a promising immunotherapy for triple negative breast cancer (TNBC), blocking PD-L1 signaling from pro-tumor cells through T PD-1 receptor binding. Nevertheless, only 10-20% of
The efficacy of trastuzumab, a treatment for HER2+ breast cancer, can be limited by the development resistance. Cyclin E (CCNE) overexpression has been implicated in trastuzumab We sought to uncover potential mechanism this resistance and focused on model CCNE overexpressing cancer noncanonical phosphorylation TGF-β signaling protein, SMAD3. Network analysis transcriptional activity HER2+, overexpressing, trastuzumab-resistant cell line (BT474R2) identified decreased SMAD3 was associated...
Suppressive myeloid cells, including monocyte and neutrophil populations, play a vital role in the metastatic cascade can inhibit anti-tumor function of cytotoxic T-cells. Cargo-free polymeric nanoparticles (NPs) have been shown to modulate innate immune cell responses multiple pathologies aberrant inflammation. Here, we test hypothesis that intravenous administration drug-free NPs 4T1 murine model triple-negative breast cancer reduce colonization lungs, primary site, by targeting pro-tumor...
A functionally suppressive antigen-driven subpopulation of macrophages has been demonstrated in mice-bearing tumors produced by MSV-transformed BALB/3T3 cells. The suppressor depressed markedly both allogeneic and syngeneic mixed leukocyte cultre responses functioned even when assayed at low concentrations, suggesting that high concentrations normal were not responsible for the suppression. Studies also showed acted to suppress proliferation hyperreactive Lyt 1+,2− cells found splenic cell...
ABSTRACT Across many types of cancer, metastatic disease is associated with a substantial decrease in 5‐year survival rates relative to only localized primary tumor. Many patients self‐report due disruption normal organ or tissue function, and earlier detection could enable treatment lower burden disease. We have previously reported subcutaneous biomaterial implant for early by serving as an engineered niche, which has been recruit tumor cells before colonization solid organs. In this...
e14555 Background: Metastasis is responsible for most cancer-related deaths and depends on the formation of a metastatic niche at distal sites. The consists primarily immunosuppressive myeloid cells, such as neutrophils monocytes. These cells are recruited to sites in response cancer-induced immune dysregulation promote recruitment survival disseminated tumor cells. We have employed drug-free poly(lactide-co-glycolide) (PLGA) nanoparticles, ONP-302, modulate cell phenotypes trafficking...