We report follow-up data evaluating the long-term outcomes for first completed trial of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy chronic, treatment-resistant post-traumatic stress disorder (PTSD) (Mithoefer et al., 2011). All 19 subjects who received MDMA-assisted treatment in original participated (LTFU), with 16 out completing all outcome measures, which were administered from 17 to 74 months after study’s final MDMA session (mean = 45.4; SD 17.3). Our primary...

Objective In recent years there has been increased interest regarding the role of crime victimization in development and/or maintenance eating disorders, particularly bulimia nervosa. Method: To examine relationship among assault, nervosa, and binge disorder, a national, representative sample 3,006 women completed structured telephone interviews. Results: Lifetime prevalence completed, forcible rape for respondents with nervosa was 26.6%, as compared 11.5% disorder 13.3% without or disorder....

Abstract Objective: The comorbidity of posttraumatic stress disorder (PTSD) and eating disorders (EDs) is high among women but has been understudied in men. Little known about the association between partial or subthreshold PTSD EDs Method: This study included ED data from male ( n = 2,382) female 3,310) National Comorbidity Survey‐Replication participants. Results: vast majority men with anorexia nervosa, bulimia nervosa (BN), binge (BED) reported a history interpersonal trauma. Rates were...

Eating disorder patients appear to have high degrees of alexithymia, a diminished capability verbally describe feelings, although little data exist. We administered the Toronto Alexithymia Scale (TAS) 114 females with DSM-III-R defined eating disorders. Patients, regardless subtype, scored significantly higher than 370 college-aged females. TAS scores were correlated self-ratings affective symptoms, but not weight or binge-purge frequency. © 1993 by John Wiley & Sons, Inc.

Studies in rodents have shown that leptin acts the central nervous system to modulate food intake and energy metabolism. To evaluate possible role of weight loss anorexia nervosa, this study compared cerebrospinal fluid (CSF) plasma concentrations anorexic patients controls. Subjects included 11 female with nervosa studied at low after treatment, 15 healthy Concentrations blood CSF were measured by RIA. Patients controls, had decreased (98 +/- 26 vs. 160 58 pg/mL; P < 0.0005) (1.75 0.46 7.01...

In this study 30 female patients with eating disorders were compared age-matched normal subjects. The demonstrated significantly higher levels of dissociative psychopathology than the comparison Furthermore, presence severe experience appeared to be specifically related a propensity for self-mutilation and suicidal behavior. These findings are discussed in light recent data which suggest that neurochemical systems shown abnormal may key pathophysiologic substrates experience.

There is disagreement about the conceptualization and measurement of pathological exercise (PE). This study seeks to elucidate nature this phenomenon as addictive or compulsive in its primary secondary forms.1,497 adults (608 men, 885 women, 4 other) completed a set validated surveys, including Godin Leisure-Time Exercise Questionnaire, Dependence Scale-21, Addiction Inventory, Compulsive Test (CET), Obligatory Commitment Scale, an specific adaptation Dimensional Obsessive-Compulsive Scale...

Eating disorders (EDs) and posttraumatic stress disorder (PTSD) are highly comorbid, yet there no proven integrative treatment modalities for ED-PTSD. In clinical trials, MDMA-assisted therapy (MDMA-AT) has shown marked success in the of PTSD may be promising Ninety individuals with severe received a double-blind, placebo-controlled pivotal trial MDMA-AT. addition to primary (Clinician-Administered Scale) secondary (Sheehan Disability outcome measures, Attitudes Test 26 (EAT-26) was...

Objective The nature of the relationship between bulimia nervosa (BN) and alcohol abuse/alcohol dependence (AA/AD) extent to which women with BN+AA differ from BN−AA were examined in a national sample (N = 3,006). Method was generated by multistage geographic sampling interviews conducted telephone. Results AA higher BN compared without or binge eating disorder, only when influence major depressive disorder (MDD) posttraumatic stress (PTSD) controlled. Prevalence rates AD similar BN, MDD,...

Several studies have examined the occurrence of eating disorders in athletes. However, little has been written about frequency and phenomenology compulsive exercising disorder (ED) patients. Given this, we studied a series 110 patients who presented to Medical University South Carolina Eating Disorders Program met lifetime DSM-III-R criteria for bulimia nervosa (n = 71), anorexia 18), or both 21). All completed Diagnostic Survey (DSED), self-report measure demographic clinical...

In a study of serotonin (5-HT) function in patients with eating disorders and healthy control subjects, severe headaches features common migraine occurred unexpectedly 28 52 subjects (54%) 8 to 12 hours after receiving single oral dose the 5-HT receptor agonist m-chlorophenylpiperazine (m-CPP), 0.5 mg/kg. None same developed similar late-occurring placebo or precursor, L-tryptophan, 100 mg/kg given intravenously. The frequency these migrainelike was not significantly different between...

The Tridimensional Personality Questionnaire (TPQ) was developed to measure a variety of personality variants on three biosocial dimensions, harm avoidance (HA), novelty seeking (NS), and reward dependence (RD), which are thought be related serotonin (5-HJ), dopamine (DA), norepinephrine (NE) function, respectively. Patients with eating disorders have been reported abnormalities in all these systems, as well described by dimensions. We therefore administered the TPQ 147 patients DSM-III-R...

There is little information about the pharmacological treatment of avoidant and restrictive food intake disorder (ARFID), a challenging feeding associated with marked impairment developmental arrest. This brief clinical report seeks to fill this gap.A retrospective chart review nine patients ARFID treated in an eating (ED) program (residential, partial hospital, intensive outpatient levels care) adjunctive olanzapine was undertaken.The mean initial final doses were 0.9 + 0.63 mg/day 2.8 1.47...