A5018208799- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Bioinformatics and Genomic Networks
- Advanced Neural Network Applications
- Hydrocarbon exploration and reservoir analysis
- Gene expression and cancer classification
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Genetics, Bioinformatics, and Biomedical Research
- Brain Tumor Detection and Classification
- Statistical Methods and Inference
- Sparse and Compressive Sensing Techniques
- Seismic Imaging and Inversion Techniques
- Parkinson's Disease Mechanisms and Treatments
- Domain Adaptation and Few-Shot Learning
- Machine Learning in Bioinformatics
- Neurobiology of Language and Bilingualism
- Diet and metabolism studies
- Pediatric Pain Management Techniques
- Nuclear Receptors and Signaling
- Computational Drug Discovery Methods
University of Pennsylvania
2012-2017
Penn Center for AIDS Research
2014-2016
Abstract Introduction Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with AD than conventional cognitive tests. Methods Elderly controls enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 158) underwent florbetapir‐PET scans, psychometric testing, neuroimaging MRI PET, APOE...
Background: Psychometric tests predict conversion of mild cognitive impairment (MCI) to probable Alzheimer's disease (AD). Because the definition clinical AD relies on those same psychometric tests, ability these identify underlying pathology remains unclear. Objective: To d etermine degree which testing predicts molecular evidence amyloid pathology, as indicated by cerebrospinal fluid (CSF) amyloid-β (Aβ)1 - 42, in patients with MCI, compared neuroimaging biomarkers. Methods: We identified...
OBJECTIVE: To assess the regions of hypoperfusion in patients with semantic variant primary progressive aphasia (svPPA) and non-fluent/agrammatic (naPPA) using pseudo-continuous arterial spin labeling (PCASL) MRI. BACKGROUND: Frontotemporal degeneration (FTD) is a neurodegenerative condition characterized by focal atrophy frontal temporal cortex. Functional imaging has been proposed as method for measuring changes cerebral blood flow (CBF) that precede structural disease. PCASL MRI...