A5032429927- Genomics and Chromatin Dynamics
- Signaling Pathways in Disease
- RNA and protein synthesis mechanisms
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Plant Genetic and Mutation Studies
- PARP inhibition in cancer therapy
- Bacteriophages and microbial interactions
- Pancreatic function and diabetes
- Heavy metals in environment
- Protein Structure and Dynamics
- Algal biology and biofuel production
- Enzyme Structure and Function
- Chromium effects and bioremediation
- RNA modifications and cancer
- Invertebrate Immune Response Mechanisms
- Plant Molecular Biology Research
Institute of Life Sciences
2021-2025
Mie University
2023
KIIT University
2021-2022
Berhampur University
2020
An organized regulation of gene expression and DNA replication is vital for the progression complex life cycle P. falciparum (Pf), involving multiple hosts various stages. These attributes rely on dynamic architecture chromatin governed by several factors, including histone chaperones. Nucleoplasmin class chaperones perform chaperoning function participate in developmental processes eukaryotes. Here, our crystal structure confirmed that Pf indeed possesses a nucleoplasmin isoform (PfNPM),...
Abstract: Rapid global modernization, urbanization, industrialization, and frequent natural processes release toxic heavy metals into the environment such as mercury (Hg), lead (Pb), cadmium (Cd), arsenic (As) selenium (Se). In present scenario, soil water ecosystems are main environmental alarms. The remediation of contaminated soils with appropriate approaches is urgently needed. Physical strategies conventional, expensive, nonspecific. contrast, phytoremediation an eco-friendly...
Histone deacetylases (HDACs), responsible for the removal of acetyl groups from histone tails, are important epigenetic factors. They play a critical role in regulation gene expression and significant context plant growth development. The Rpd3/Hda1 family HDACs is reported to regulate key biological processes plants, such as stress response, seed, embryonic, floral Here, we characterized Arabidopsis thaliana HDA7, Class I, HDAC. SAXS AUC results show that recombinantly expressed purified...
Histone proteins associate with DNA to form the eukaryotic chromatin. The basic unit of chromatin is a nucleosome, made up histone octamer consisting two copies core histones H2A, H2B, H3, and H4, wrapped around by DNA. composed an H2A/H2B dimer single copy H3/H4 tetramer. highly charged are prone non-specific interactions several in cellular cytoplasm nucleus. chaperones diverse class that shuttle from into nucleus aid their deposition onto DNA, thus assisting nucleosome assembly process....
Histone deacetylases (HDACs), responsible for the removal of acetyl groups from histone tails, are important epigenetic factors. They play a critical role in regulation gene expression and significant context plant growth development. The Rpd3/Hda1 family HDACs is reported to regulate key biological processes plants, such as stress response, seed, embryonic, floral Here, we characterized Arabidopsis thaliana HDA7, Class I, HDAC. SAXS AUC results show that recombinantly expressed purified...
ABSTRACT The nucleoplasmin family of histone chaperones is a key player in governing the dynamic architecture chromatin, thereby regulating various DNA-templated processes. crystal structure N-terminal domain Arabidopsis thaliana FKBP43 (AtFKBP43), an FK506-binding immunophilin protein, revealed characteristic fold, thus confirming it to be member FKBP class. Small-Angle X-ray Scattering (SAXS) analyses confirmed its pentameric nature solution, and additional studies fold highly stable....