A5078939168- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune Bullous Skin Diseases
- Pharmaceutical studies and practices
- Autoimmune and Inflammatory Disorders Research
- Oral Health Pathology and Treatment
- Spondyloarthritis Studies and Treatments
- Clinical practice guidelines implementation
- Biosimilars and Bioanalytical Methods
- Oral and Maxillofacial Pathology
- Complementary and Alternative Medicine Studies
- Research on Leishmaniasis Studies
- Advancements in Transdermal Drug Delivery
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infectious Diseases and Mycology
- Retinoids in leukemia and cellular processes
- Genetic factors in colorectal cancer
- Autoimmune and Inflammatory Disorders
- Mycobacterium research and diagnosis
- Respiratory Support and Mechanisms
- Cancer and Skin Lesions
- Tuberculosis Research and Epidemiology
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
Bellvitge University Hospital
2016-2025
Animal Free Research UK
2025
Universitat de Barcelona
1996-2024
Institut d'Investigació Biomédica de Bellvitge
2011-2024
Ajuntament de L’Hospitalet
2023
Helsinki University Hospital
2023
Technical University of Munich
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
Fundación Instituto Valenciano de Oncología
2023
Aristotle University of Thessaloniki
2023
La terapia biológica representa una alternativa bien establecida en el manejo de la psoriasis moderada y grave. Sin embargo, su elevado coste, experiencia relativamente limitada empleo clínico abundancia publicaciones existentes hacen necesario desarrollo unas directrices basadas evidencia científica disponible consenso un grupo expertos. El objetivo ideal del tratamiento es conseguir mantener a largo plazo blanqueamiento completo o prácticamente o, defecto, mínima afectación localizada...
Background: The efficacy and safety of secukinumab in patients with plaque psoriasis (PsO) have been demonstrated randomized clinical trials (RCTs). However, data regarding its real-life settings are scarce. Objectives: To evaluate the practice PsO attending 10 dermatology centers Spain. Methods: Data from 136 consecutively treated for at least 52 weeks were collected a retrospective observational study. Results: After treatment, 69% 46% achieved PASI-75, PASI-90, respectively. PASI-score ≤5...
The diagnosis of adult-onset Still's disease (AOSD) can be very difficult. There are no specific tests available, and is usually based on a symptom complex the well-described typical evanescent rash seen in majority patients. However, recent years, other atypical cutaneous manifestations AOSD have been reported. These skin eruptions often present addition to but may also only manifestation, resulting delayed because under-recognition.In this study, we 3 new cases with diagnosed during...
Biologic therapy is a well-established strategy for managing moderate and severe psoriasis. Nevertheless, the high cost of such therapy, relatively short span clinical experience with biologics, abundance literature now available on these agents have made evidence-based consensus-based guidelines necessary. The ideal goal psoriasis treatment to achieve complete or nearly clearing lesions maintain it over time. Failing that ideal, would be reduce involvement localized can controlled topical...
Ixekizumab (anti-IL17A) is effective as treatment for moderate-to-severe plaque psoriasis, but real-life data on effectiveness and safety are currently very limited.To evaluate the efficacy of ixekizumab in a cohort psoriasis patients.Retrospective chart review 100 patients with treated at seven Spanish dermatological centres.According to observed analysis, percentage achieving 75% 90% reduction from baseline score Psoriasis Area Severity Index (PASI) was 87.5%-50.0% week 12-16; 88.3%-58.4%...
Abstract A 13‐year‐old, female, neutered Border Collie visited the neurology department after suffering two separate episodes of hindlimb weakness and pain. The patient responded to rest analgesia on both occasions, but continued be reluctant jump. Previous history reported closure a patent ductus arteriosus, using an Amplatz canine duct occluder at age 1. An electrocardiogram‐gated computed tomography showed lesion in aortic arch, which was consistent with thrombus, centred over occluder....
Phototherapy, classic systemic treatments (methotrexate, acitretin, and ciclosporin), biologic agents (etanercept, infliximab, adalimumab, ustekinumab) constitute a broad therapeutic arsenal that increases the likelihood of achieving control severe extensive disease in patients with psoriasis. Acitretin continues to be very valuable tool both monotherapy, which it is combined other (classic or biologic), sequential therapy. Thanks its lack direct immunosuppressive effect ability achieve...
Abstract Introduction Hidradenitis suppurativa ( HS ) is a chronic skin disease which causes great impact in the quality of life. Multiple therapeutic options have been proposed, and recently potential use biological drugs severe cases has postulated. Material Methods A retrospective study from seven tertiary Spanish centers reviewing charts patients with treated was performed. Retrieved information included epidemiological data, clinical features, pain intensity, Hurley stage, laboratory...
Psoriasis, a chronic multifactorial inflammatory disease that develops in genetically predisposed individuals, affects approximately 1.5% of the Spanish population. This has negative impact on patients' quality life, and long-term therapy is often required to control symptoms. In addition classical systemic treatments (methotrexate, acitretin, cyclosporine, ultraviolet light), group drugs known as biologics (etanercept, infliximab, adalimumab, ustekinumab) provides dermatologist with an...
Abstract Background Normally, percutaneous absorption tests are carried out using skin biopsies for an apparent and acceptable physiological condition. However, under different pathological conditions, the stratum corneum (SC) barrier function is impaired. Methods The of SC was assessed by correlation between number repeated applications tape strips on its transepidermal water loss (TEWL), as well in vitro studies compounds, Franz diffusion cells porcine previously stripped. Results A...
The Psoriasis Area Severity Index (PASI) is the most widely used scale for assessing severity of psoriasis and therapeutic decision making. On basis PASI score, patients have been stratified into 2 groups: mild disease moderate-to-severe disease. To draft a proposal definition characterization moderate based on Dermatology Life Quality (DLQI) scores. A group 6 dermatologists with experience in treatment undertook critical review literature discussion cases to proposal. In order priority,...
Data on the effectiveness and safety of a drug in real-world clinical practice complement evidence from trials, which are carried out different setting. Little has been published guselkumab treatment psoriasis practice. The ojective this study was to assess at 24 weeks patients with moderate severe plaque routine A retrospective, multicentre adult treated for least Spain. We studied 343 patients, 249 whom were followed weeks. By week 24, mean (SD) area severity index (PASI) had decreased...
The aim of our study was to determine the influence several types liposomes with a different lipid composition on percutaneous absorption one conventional sun filter lipophilic character (ethyl hexyl methoxycinnamate) using both in vitro and vivo methodologies. Three were prepared unsaturated saturated phosphatidylcholine (PC, HPC) wool mixture (IWL) similar that stratum corneum lipids. Results showed liquid crystalline state associated PC plays key role enhancing skin penetration. When...
Treatment persistence is becoming a useful measure to evaluate long-term effectiveness and safety of biological therapies in real-world settings.The main objective this study was explore the scientific opinion panel dermatologists hospital pharmacists reach consensus about impact, causes, best strategies interventions that might be associated with improved drug patients psoriasis Spain.This research conducted using modified Delphi method organized two rounds involving 90 34 pharmacists. A...
Several studies suggest that patients with psoriasis have a higher incidence of neoplasms, especially the skin, which could be associated use therapies to treat psoriasis. Furthermore, evidence available on safety profile some treatments in this context, and management these is scarce, why clinical practice guidelines recommendations cancer are ambiguous. This study provides currently for patients. They result Delphi consensus reached by 45 dermatologists Spanish Academy Dermatology...
Pasados ya unos anos desde el inicio de la terapia biologica en psoriasis y, por lo tanto, asumidas las perspectivas prometidas a corto y medio plazo los ensayos clinicos pivotales, objetivo del dermatologo con experiencia manejo esta enfermedad va hoy dia mas alla. De este modo, expectativas van transcender al alcance respuesta esperada para ponderar que probabilidades hay un farmaco una inicial satisfactoria durante primeros meses siga siendo opcion adecuada mayor tiempo posible. Las...