Mythra Varun Nemallapudi

ORCID: 0000-0001-9687-3129
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About
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Research Areas
  • Radiation Detection and Scintillator Technologies
  • Particle physics theoretical and experimental studies
  • Medical Imaging Techniques and Applications
  • Particle Detector Development and Performance
  • Quantum Chromodynamics and Particle Interactions
  • High-Energy Particle Collisions Research
  • Atomic and Subatomic Physics Research
  • Radiation Therapy and Dosimetry
  • Advanced Radiotherapy Techniques
  • CCD and CMOS Imaging Sensors
  • Plasma Diagnostics and Applications
  • Laser Design and Applications
  • Dark Matter and Cosmic Phenomena
  • Nuclear Physics and Applications
  • Advanced Optical Sensing Technologies
  • Photocathodes and Microchannel Plates

Institute of Physics, Academia Sinica
2022-2024

Academia Sinica
2021

LIP - Laboratory of Instrumentation and Experimental Particle Physics
2017-2018

European Organization for Nuclear Research
2013-2017

Time of flight (TOF) in positron emission tomography (PET) has experienced a revival interest after its first introduction the eighties. This is due to significant progress solid state photodetectors (SiPMs) and newly developed scintillators (LSO derivatives). Latest developments at Fondazione Bruno Kessler (FBK) lead NUV-HD SiPM with very high photon detection efficiency around 55%. Despite large area 4×4 mm2 it achieves good single time resolution (SPTR) 180±5ps FWHM. Coincidence (CTR)...

10.1088/1748-0221/11/08/p08008 article EN cc-by Journal of Instrumentation 2016-08-08

The coincidence time resolution (CTR) becomes a key parameter of 511keV gamma detection in flight positron emission tomography (TOF-PET). This is because additional information obtained through timing leads to better noise suppression and therefore signal ratio the reconstructed image. In this paper we present results CTR measurements on two different SiPM technologies from FBK coupled LSO:Ce codoped 0.4%Ca crystals. We compare performed at separate test setups, i.e. CERN FBK, showing that...

10.1088/0031-9155/60/12/4635 article EN Physics in Medicine and Biology 2015-05-28

Comparison of the timing performance different silicon photomultipliers (SiPMs) can be useful for applications that employ these devices. In our study, we characterize some currently available SiPMs to compare single photon time resolution (SPTR) values measured using a 420 nm laser with pulse width 42 ps FWHM. SPTR in range 175–330 FWHM were most 3 × mm2 and 4 devices varied producer type SiPM. Factors influencing including area, cell non-uniformity SPAD (single avalanche diode) jitter...

10.1088/1748-0221/11/10/p10016 article EN cc-by Journal of Instrumentation 2016-10-21

Universitat de Barcelona (UB) and CIEMAT have designed the FlexToT ASIC for front-end readout of SiPM-based scintillator detectors. This is aimed at time flight (ToF) positron emission tomography (PET) applications. In this work we evaluated performance v2 compared to NINO ASIC, a fast developped CERN. electronics give 64 ps sigma single-photon resolution (SPTR) 93 FWHM coincidence (CTR) with 2 × 5 mm3 LSO:Ce,Ca crystals S13360-3050CS SiPMs. Using same SiPMs crystals, yields 91 SPTR 123 CTR....

10.1088/1748-0221/12/04/p04016 article EN cc-by Journal of Instrumentation 2017-04-13

The simulation of Micro Pattern Gaseous Detectors (MPGDs) signal response is an important and powerful tool for the design optimization such detectors. However, several attempts to simulate exactly effective charge gain have not been completely successful. Namely, stability over time has fully understood. Charging-up insulator surfaces pointed as one responsible difference between experimental Monte Carlo results. This work describes two iterative methods charging-up in MPGD device, Gas...

10.1088/1748-0221/9/07/p07025 article EN cc-by Journal of Instrumentation 2014-07-24

Abstract Objective . Obtaining the intrinsic dose distributions in particle therapy is a challenging problem that needs to be addressed by imaging algorithms take advantage of secondary detectors. In this work, we investigate utility deep learning methods for achieving direct mapping from detector data distribution. Approach We performed Monte Carlo simulations using GATE/Geant4 10.4 simulation toolkits generate dataset human CT phantom irradiated with high-energy protons and imaged compact...

10.1088/1361-6560/ac8af5 article EN cc-by Physics in Medicine and Biology 2022-08-18

Optical coupling of scintillators with photodetectors is important to increase the achievable light output. Understanding angular response crucial enhance extraction. Losses induced by Fresnel reflections on a Silicon Photomultiplier (SiPM) surface result in an dependence detected signal incident light. We built dedicated test bench at CERN make systematic study samples various specifications and manufacturers. present results this study.

10.1109/nssmic.2013.6829586 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2013-10-01

It is important to optimize the crystal-photodetector coupling for gamma detection since it improves light extraction and directly linked achieved time resolution. In this paper we present our work on altering geometry of crystal face enhance output. Simulations compare output alternative geometries with respect that regular cuboid geometry. We machined two different shapes from 2 × 15 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup>...

10.1109/tns.2016.2535491 article EN IEEE Transactions on Nuclear Science 2016-04-01

. Lutetium yttrium oxyorthosilicate (LYSO) scintillation crystals are used in positron emission tomography (PET) due to their high gamma attenuation, fair energy resolution, and fast decay time. The enduring presence of the

10.1088/1361-6560/ad2e6e article EN cc-by Physics in Medicine and Biology 2024-02-28

Proton therapy for cancer treatment has a precise dose deposition capability owing to the nature of interactions heavy charge particles with matter resulting in Bragg Peak. Uncertainties proton range can limit scope therapy. Academia Sinica PET employs modular design In-beam detection using SiPMs and crystals read out by STiC asic verification. In this work we report depth distribution positron emitters from PMMA sample irradiated 130-MeV protons at Chang Gung Memorial Hospital measured...

10.1109/trpms.2021.3084953 article EN IEEE Transactions on Radiation and Plasma Medical Sciences 2021-05-31

The distribution of the prompt gamma emissions induced by proton interactions in a target material carries information concerning range and composition. In order to image we present different approaches. first approach is based on knife-edge collimator utilized tandem with compact PET type detector verify measuring depth relying Compton scattered events. A second aims at unambiguously identifying presence protons region interest introducing bio-compatible fiducial marker patient...

10.48550/arxiv.2205.00200 preprint EN cc-by-nc-nd arXiv (Cornell University) 2022-01-01

Demand for large area parallel plate ionization chamber (PPIC) or (LAIC) has risen in recent years due to several advantages of the effective monitoring therapeutic radiation beams. PPICs are designed measurements beam profile and dosimetry therapy quality assurance (QA) procedures.Objective. Heterogeneous responses over sensitive pose an undeniable concern straightforward applications clinical dosimetry. Uniformity calibration detector response is thus essential accurate performance each...

10.1088/1361-6560/aca9b5 article EN Physics in Medicine and Biology 2022-12-07
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