A5030155425- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Poisoning and overdose treatments
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Traditional and Medicinal Uses of Annonaceae
- Alcohol Consumption and Health Effects
- Opioid Use Disorder Treatment
- Epilepsy research and treatment
- Animal Ecology and Behavior Studies
- Chemical synthesis and alkaloids
- Plant-based Medicinal Research
- Alkaloids: synthesis and pharmacology
Cannabinoid is the most frequently reported illicit drug class in Driving Under Influence of Drugs (DUID) investigation casework. In recent years, our laboratory observed an increasing rate overlapping peaks for cannabinoid confirmation performed using 2D high-performance liquid chromatography (LC)--tandem mass spectrometry (MS-MS). Starting early 2018, incidence unresolved interfering substances increased, contributing to a higher canceled testing that peaked at 3.7% February 2019. The...
This report describes updates to the National Safety Council's Alcohol, Drugs and Impairment Division's recommendations for drug testing in driving under influence of (DUID) cases motor vehicle fatalities. The are based on a survey practices laboratories USA Canada, comprehensive review prior data research drugs most frequently detected DUID cases. A consensus meeting was held with representative forensic science practitioners authors this update recommendations. No changes were made Tier I...
Mitragynine is the primary active alkaloid in leaves of tropical tree Mitragyna speciosa, and goes by popular names "Kratom", biak-biak maeng da. increasingly seen forensic toxicology casework including driving under influence drugs medicolegal death investigation cases. The toxicity mitragynine continues to be debated scientific community as advocates highlight its long history use Southeast Asia testimonials benefits present-day users, while opponents point an increasing number adverse...
Designer benzodiazepine (DBZD) use has been increasing over the past decade and poses a threat to human health safety, particularly when involved in driving under influence of drug (DUID) cases. Over 5-year period between 2017 2021, there were 1,145 reported DBZDs 805 blood samples submitted from law enforcement agencies for DUID testing. Eleven different detected, including three metabolite pairs: etizolam/alpha-hydroxyetizolam, clonazolam/8-aminoclonazolam, diclazepam/delorazepam,...
Abstract The increasing use and misuse of gabapentin pose a major risk to public health traffic safety. Gabapentin has been approved by the Food Drug Administration (FDA) since 1993 for adjunctive therapy in treatment epilepsy neuralgia but is increasingly being prescribed numerous off‐label uses including insomnia, anxiety, depression, migraine. Reported side effects include blurred vision, drowsiness, loss coordination. Driving behaviors such as exiting lane travel crashes have reported...
In the past 3 years, widespread interest in cannabinoid products containing delta-8 tetrahydrocannabinol (delta-8 THC) has increased (1), as have debates about its legal status (2–4) USA. Delta-8 THC is an isomer of delta-9 THC, most prominent psychoactive component Cannabis sativa. estimated to ∼60% potency (5) and comparable one-third binding affinity at both receptor (CB) 1 CB2 (6, 7), so a drug forensic concern. Toxicology laboratories are facing increasing requests identify quantify...