A5080416799- Enzyme function and inhibition
- Polyamine Metabolism and Applications
- Renin-Angiotensin System Studies
- Cholinesterase and Neurodegenerative Diseases
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Bacterial biofilms and quorum sensing
- Pancreatic function and diabetes
- Biomarkers in Disease Mechanisms
- Phosphodiesterase function and regulation
- Diabetes Management and Research
- Cancer Mechanisms and Therapy
- Biochemical Analysis and Sensing Techniques
- Cancer, Hypoxia, and Metabolism
- Diabetes and associated disorders
- Synthesis and Catalytic Reactions
- Ocular Infections and Treatments
- Olfactory and Sensory Function Studies
- Adipose Tissue and Metabolism
- Legionella and Acanthamoeba research
Tampere University
2012-2023
Fimlab (Finland)
2012
Carbonic anhydrase VI (CA VI) is a secretory isozyme of the α-CA gene family. It highly expressed in salivary and mammary glands secreted into saliva milk. Although CA was first described as gustatory protein, its exact functional roles have remained enigmatic. Interestingly, polymorphism CA6 recently linked to bitter taste perception humans. In this study, we compared preference Car6−/− wild-type mice for different modalities an IntelliCage monitoring environment. Morphologies buds, tongue...
Carbonic anhydrases (CAs) are ubiquitous, essential enzymes which catalyze the conversion of carbon dioxide and water to bicarbonate H+ ions. Vertebrate genomes generally contain gene loci for 15-21 different CA isoforms, three enzymatically inactive. VI is only secretory protein active isoforms. We discovered that non-mammalian contains a C-terminal pentraxin (PTX) domain, novel combination both CAs PTXs. isolated sequenced zebrafish (Danio rerio) cDNA, complete with sequence coding PTX...
Acanthamoeba keratitis is a devastating infectious disease of the cornea caused by an opportunistic amoeba, castellanii. It poorly recognized, and diagnostic delays can lead to irreversible damage vision. The gold standard for diagnosis has been sample culture that lasts approximately 2 weeks. Nevertheless, essence time led need accurate fast technique detect A. castellanii from sample. We developed both traditional quantitative real-time-PCR-based methods in less than 3 hours with...
Carbonic anhydrases (CA, EC 4.2.1.1) catalyze the hydration of carbon dioxide and take part in many essential physiological processes. In humans, 15 CAs are characterized, including only secreted isoenzyme CA VI. VI has been linked to specific processes mouth, namely bitter taste perception, dental caries, maintenance enamel pellicle, implicated several immunity-related phenomena. However, little is known mechanisms above. this study, we characterized human purified from saliva milk with...
Carbonic anhydrases (CAs) contribute to tumor cell migration by generating an acidic environment through the conversion of carbon dioxide bicarbonate and a proton. CA VI is secreted milk saliva, it could wound closure, as potential trophic factor, in animals that typically lick their wounds. Our aim was investigate whether human improves skin-wound healing full-thickness models. The effect studied Car6 −/− knockout mice wild type littermates. Half both strains were given topically...