A5083267547- Diabetes and associated disorders
- Viral gastroenteritis research and epidemiology
- Celiac Disease Research and Management
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Viral Infections and Immunology Research
- Diabetes Management and Research
- Pediatric health and respiratory diseases
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Microscopic Colitis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Vitamin D Research Studies
- Pediatric Pain Management Techniques
- Helicobacter pylori-related gastroenterology studies
- Thyroid Disorders and Treatments
- Pharmaceutical studies and practices
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Obesity, Physical Activity, Diet
Tampere University
2007-2021
Petrozavodsk State University
2004-2011
Finnish Diabetes Association
2007
Diabetes Tutkimussaatio
2005
Type 1 diabetes results from gene-environment interactions in subjects with genetic susceptibility to the disease. We assessed contribution of environmental and factors type by comparing incidence two neighboring populations living conspicuously different socioeconomic circumstances.We compared over a 10-year period (1990-99) children younger than 15 years age Karelian Republic Russia Finland. The frequency susceptible protective human leukocyte antigen (HLA)-DQ alleles was analyzed 400...
Background. The populations in adjacent Russian Karelia and Finland are equally exposed to grain products share partly the same ancestry, but live completely different socioeconomic environments.Aim. This creates an ideal epidemiological setting study gene‐environmental interactions pathogenesis of celiac disease.Methods. prevalence disease predisposing human leukocyte antigen (HLA) alleles was compared between Finland. Tissue transglutaminase antibodies HLA‐DQ were screened from 1988...
Summary Epidemiological data have indicated that some infections are associated with a low risk of allergic diseases, thus supporting the idea (hygiene hypothesis) microbial load is an important environmental factor conferring protection against development allergies. We set out to test hygiene hypothesis in unique epidemiological setting two socio-economically and culturally markedly different, although genetically related, populations living geographically adjacent areas. The study cohorts...
Abstract Upregulation of IL-17 immunity and detrimental effects on human islets have been implicated in type 1 diabetes. In animal models, the plasticity Th1/Th17 cells contributes to development autoimmune this study, we demonstrate that upregulation pathway peripheral blood are markers advanced β cell autoimmunity impaired function Activated Th17 was observed late stage preclinical diabetes children with glucose tolerance, but not early autoimmunity. We found an increased ratio IFN-γ/IL-17...
Abstract The incidence of type 1 diabetes varies markedly between countries. As enterovirus infections have been linked to diabetes, we determined whether this variation correlates with the frequency in different Caucasian populations Europe. Enterovirus antibodies were examined background population (1‐year‐old and 10‐14–year‐old children) seven countries either exceptionally high (Finland Sweden) or low/intermediate (Estonia, Germany, Hungary, Lithuania, Russia) using EIA neutralisation...
The mechanisms leading to thyroid autoimmunity are largely unknown.Our objective was assess the role of environment in development autoimmunity.Prevalence autoantibodies two neighboring populations living completely different socioeconomic circumstances (Russian Karelia and Finland) studied.We studied population-based cohorts partly sharing same ancestry.A total 532 schoolchildren from Russian Finland matched for age, gender, season blood sampling were included.There no interventions.The...
The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in developed world. In order to explore differences gene expression patterns induced utero infants born contrasting standards living hygiene, we collected umbilical cord blood RNA samples from Finland (modern society), Estonia (rapidly developing society) Republic Karelia, Russia (poor economic conditions). whole transcriptome Finnish Estonian neonates differed their Karelian counterparts,...
OBJECTIVE—We sought to study the prevalence of autoantibodies various islet cell antigens in background population two neighboring countries with a sixfold difference incidence type 1 diabetes. RESEARCH DESIGN AND METHODS—Serum samples were obtained from 3,652 nondiabetic schoolchildren Finland and 1,988 adjacent Karelian Republic Russia. The children divided into three groups (Finns/Karelians, Russians, others) based on ethnic their mother. analyzed for antibodies (ICAs), insulin (IAAs),...
The function of the exocrine pancreas is decreased in patients with type 1 diabetes but it not known when this defect develops. current study set out to determine whether reduced becomes manifest after initiation islet autoimmunity.The was nested prospective Type Diabetes Prediction and Prevention where children human leukocyte antigen (HLA)-conferred susceptibility are observed from birth. Elastase-1 levels were analyzed stool samples collected at time seroconversion autoantibody positivity...
Background. The mechanisms leading to abnormal immune regulation in type 1 diabetes and allergic diseases may be partly overlapping. If so, these should co-occur more often than expected. We investigated this phenomenon two contrasting socio-economic environments, Finland Russian Karelia.Methods. screened 413 Finnish children (of whom 147 had diabetes) 244 Karelian (132 for total immunoglobulin E (IgE) levels specific IgE against birch, cat, egg albumen. In addition we analysed...
Summary Background Enterovirus infections in childhood have been associated with a reduced risk of atopy cross‐sectional studies. Objective To study the relation between enterovirus first 2 years life and atopic disease IgE sensitization prospective setting. Methods This was nested case‐control among children who had followed from birth. Neutralizing antibodies against 12 serotypes were analysed at age 71 142 non‐atopic control children. Atopy defined as having an least one aeroallergen by 5...
Abstract Among other infectious agents, enteroviruses have been associated with protection against allergic diseases. The aim of the present study was to confirm these findings using a highly sensitive and specific neutralization antibody assay investigate whether protective effect is related certain enterovirus serotypes. Antibodies 12 serotypes were measured in 60 children who positive for allergen‐specific IgE 190 control children. Echoviruses seemed be more than coxsackie‐B‐viruses...
Summary Background Total serum IgE is regulated by both environmental and genetic factors. Association linkage studies have suggested a role of CD14 −159C>T polymorphism in the regulation total IgE, but results been contradictory. It seems that gene–environment interactions are involved this regulation. Objective The aim study was to examine possible among Toxoplasma gondii, Helicobacter pylori, Toll‐like receptor (TLR) 4 +896A>G on IgE. For study, we expanded scope our earlier...
Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. We set out to investigate immunomodulatory effects early viral experienced before age one year on peripheral regulatory T cell population (Treg) circulating cytokines a birth-cohort study Estonian Finnish infants. show here temporal association virus infection with expression FOXP3 cells. Infants rhinovirus during preceding 30 days had higher Treg...