A5072608350- Human Health and Disease
- Healthcare Systems and Public Health
- Pediatric health and respiratory diseases
- Diabetes and associated disorders
- Trace Elements in Health
- Medical and Agricultural Research Studies
- Gastroesophageal reflux and treatments
- Pediatric Pain Management Techniques
- Eosinophilic Esophagitis
- Selenium in Biological Systems
- Microscopic Colitis
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Economic, Social, and Public Health Issues in Russia and Globally
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Immune Response and Inflammation
- Pharmaceutical studies and practices
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Agricultural Productivity and Crop Improvement
- Soil and Environmental Studies
- Botany and Plant Ecology Studies
Petrozavodsk State University
2014-2024
Abstract Upregulation of IL-17 immunity and detrimental effects on human islets have been implicated in type 1 diabetes. In animal models, the plasticity Th1/Th17 cells contributes to development autoimmune this study, we demonstrate that upregulation pathway peripheral blood are markers advanced β cell autoimmunity impaired function Activated Th17 was observed late stage preclinical diabetes children with glucose tolerance, but not early autoimmunity. We found an increased ratio IFN-γ/IL-17...
The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in developed world. In order to explore differences gene expression patterns induced utero infants born contrasting standards living hygiene, we collected umbilical cord blood RNA samples from Finland (modern society), Estonia (rapidly developing society) Republic Karelia, Russia (poor economic conditions). whole transcriptome Finnish Estonian neonates differed their Karelian counterparts,...
Rationale. During the COVID-19 pandemic, there was a sharp increase in incidence of community-acquired pneumonia (CAP) Russia and Republic Karelia (RK). Given high significance problem, it is necessary to clarify causes current epidemiological situation. The purpose work : assess CAP, not associated with COVID-19, adult population aged 18 years older 2011–2019 administrative-territorial divisions republic, comparison its existing projected levels 2020–2021. Material method. A retrospective...
Pneumonia remains one of the most pressing problems pulmonology. Despite significant advances in antibacterial and antiviral therapy, mortality from this disease is not going down. Environmental factors play a role development community-acquired pneumonia adults. In northern regions, such as Republic Karelia, environmental conditions unfavorable for human health act risk that contribute to occurrence or worsening disease. The like other territories, has certain characteristics terms content...
The problem of the peptic ulcer disease is one most urgent problems in gastroenterology. In spite modern achievements, this very hard to nurse. article has highlighted results epidemiological research regions European North оf Russia period 2009-2013. analysis data shown that five North, total and primary incidence was above average for Russian Federation. Republic Karelia (RK), Komi Arkhangelsk Region, indicators both general were highest disadvantaged region, where 1.4-1.6-fold higher than...
The problem of the peptic ulcer disease is one most urgent problems in gastroenterology. In spite modern achievements, this very hard to nurse. article has highlighted results epidemiological research regions European North оf Russia period 2009-2013. analysis data shown that five North, total and primary incidence was above average for Russian Federation. Republic Karelia (RK), Komi Arkhangelsk Region, indicators both general were highest disadvantaged region, where 1.4-1.6-fold higher than...
Objective: to estimate the quality of life (QOL) in patients with duodenal ulcers residing North European part Russia and treated by melatonin therapy addition standard anti-ulcer using GSRS questionnaire. Materials methods: study involved 80 uncomplicated ulcer acute stage randomized into 2 groups: group I (n= 40) given three-component treatment (omeprazole, clarithromycin, amoxicillin) (control, n=40) same but without melatonin. Taking account peculiarities photoperiodicity region, 1 was...
The study of herbaceous vegetation growing in different parts the City Petrozavodsk varying lead-pollution levels was conducted. It established that communities formed at contaminated sites were characterized by fewer species (genera and families) than those relatively clean territories, a higher share more tolerant family Poaceae , decrease production aboveground biomass. At same time, absolute values majority morphometric characters, among which most sensitive to soil pollution is “leaf...
Introduction: The Republic of Karelia is a part the Northwestern Federal District and, being sparsely populated constituent entity Russian Federation, characterized by difficult medical and demographic situation. Objective: To assess trends in processes 2011–2021. Materials methods: We analyzed official statistical data provided Territorial Body State Statistics Service for years 2011 to 2021. Both absolute relative values time series indicators were used characterize under study. Results: A...
The analysis of basic medical and demographic indicators (primary morbidity disability adult population, mortality, age structure life expectancy) provision care in the Republic Karelia 2011-2020 was carried out. It established consistently high level primary population with respiratory diseases; injuries, poisoning other consequences external causes; diseases genitourinary system. Diseases cardiovascular system malignant neoplasms occupy leading positions causes mortality during period...
The article presents results of investigation element homeostasis in 62 patients (males and females) with community-acquired pneumonia living Karelia. Atomic-emission atomic-absorption spectroscopy methods were used. Statistically significant decrease mass concentrations Zn, Fe Mn increase Cd Cu found the whole blood men at onset disease; concentration women. authors offered differentiated techniques for dietary medication correction these disturbances.
Objective: to study changes in the course of duodenal ulcer patients residing European North, using melatonin as an addition standard antiulcer therapy. Materials and methods: involved 80 with uncomplicated active ulcer. Patients were divided into 2 groups: Group I (test, 40 patients), received a triple regimen (omeprazole, clarithromycin, amoxicillin) addition; II (control, patients) only regimen. Taking account peculiarities photoperiodism region subgroups A B marked 1st Group, C D - 2nd...
Type 1 diabetes mellitus is one of the most common autoimmune diseases in world. The Republic Karelia belongs to a group regions with high prevalence rate type (over 200 per 100,000 residents). In last 20 years, incidence has increased 3.4 times, mostly due onset at an early age. new cases among children and adolescents does not show any clear linear dependence. Significant occur every 4 or 5 which likely be connected increase virus infection these years. primary 100 thousand child...