A5054190084- Diabetes and associated disorders
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
- COVID-19 diagnosis using AI
- IL-33, ST2, and ILC Pathways
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- HIV-related health complications and treatments
- SARS-CoV-2 detection and testing
- Gut microbiota and health
- interferon and immune responses
- Asthma and respiratory diseases
- COVID-19 Digital Contact Tracing
- Clostridium difficile and Clostridium perfringens research
- Craniofacial Disorders and Treatments
- HIV/AIDS Research and Interventions
Tampere University Hospital
2006-2023
Tampere University
2009-2023
Finnish Diabetes Association
2002-2009
Pirkanmaa Hospital District
2007
University of Turku
2005
Type 1 diabetes results from gene-environment interactions in subjects with genetic susceptibility to the disease. We assessed contribution of environmental and factors type by comparing incidence two neighboring populations living conspicuously different socioeconomic circumstances.We compared over a 10-year period (1990-99) children younger than 15 years age Karelian Republic Russia Finland. The frequency susceptible protective human leukocyte antigen (HLA)-DQ alleles was analyzed 400...
Background. The populations in adjacent Russian Karelia and Finland are equally exposed to grain products share partly the same ancestry, but live completely different socioeconomic environments.Aim. This creates an ideal epidemiological setting study gene‐environmental interactions pathogenesis of celiac disease.Methods. prevalence disease predisposing human leukocyte antigen (HLA) alleles was compared between Finland. Tissue transglutaminase antibodies HLA‐DQ were screened from 1988...
Summary Epidemiological data have indicated that some infections are associated with a low risk of allergic diseases, thus supporting the idea (hygiene hypothesis) microbial load is an important environmental factor conferring protection against development allergies. We set out to test hygiene hypothesis in unique epidemiological setting two socio-economically and culturally markedly different, although genetically related, populations living geographically adjacent areas. The study cohorts...
Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil plant-based material.We performed a pilot study in which healthy adults were exposed varied community of soil- material.The method was safe feasible; exposure associated with an increase gut diversity.If these findings reproduced larger studies nature-derived strategies could be further developed for testing their...
Abstract The epidemiology, transmission and clinical symptoms of human parechoviruses [HPeV, classified earlier as enteroviruses; echovirus 22 (HPeV1) 23 (HPeV2)] remain poorly characterized. Enteroviruses one parechovirus species, the Ljungan virus, have been associated with type 1 diabetes in humans rodents. occurrence infections young children their possible association was evaluated. prospective birth cohort study comprised 221 Finnish carrying genetic susceptibility who were observed...
Abstract The incidence of type 1 diabetes varies markedly between countries. As enterovirus infections have been linked to diabetes, we determined whether this variation correlates with the frequency in different Caucasian populations Europe. Enterovirus antibodies were examined background population (1‐year‐old and 10‐14–year‐old children) seven countries either exceptionally high (Finland Sweden) or low/intermediate (Estonia, Germany, Hungary, Lithuania, Russia) using EIA neutralisation...
The mechanisms leading to thyroid autoimmunity are largely unknown.Our objective was assess the role of environment in development autoimmunity.Prevalence autoantibodies two neighboring populations living completely different socioeconomic circumstances (Russian Karelia and Finland) studied.We studied population-based cohorts partly sharing same ancestry.A total 532 schoolchildren from Russian Finland matched for age, gender, season blood sampling were included.There no interventions.The...
Maternal enterovirus infections during pregnancy have been linked to an increased risk of type 1 diabetes in the offspring. The aim this study was evaluate association a unique series pregnant mothers whose child progressed clinical diabetes.Maternal and utero were studied 171 offspring who presented with before age 11 years 316 control subjects matched for date place birth, sex, HLA-DQ alleles diabetes. Acute diagnosed by increases IgG IgM samples taken from mother at end first trimester...
Previous studies have suggested that enterovirus infections during pregnancy may increase the risk of type 1 diabetes in offspring. Our aim was to evaluate role first trimester a larger cohort pregnant women. Two series women were analyzed as follows: 948 (series 1) and 680 2) whose child developed clinical before ages 15 or 7 years, respectively. An equal number control with nondiabetic selected. Acute diagnosed by measuring IgM class antibodies against coxsackievirus B5 mixture B3, A16,...
OBJECTIVE—We sought to study the prevalence of autoantibodies various islet cell antigens in background population two neighboring countries with a sixfold difference incidence type 1 diabetes. RESEARCH DESIGN AND METHODS—Serum samples were obtained from 3,652 nondiabetic schoolchildren Finland and 1,988 adjacent Karelian Republic Russia. The children divided into three groups (Finns/Karelians, Russians, others) based on ethnic their mother. analyzed for antibodies (ICAs), insulin (IAAs),...
Antibody class-switch recombination and somatic hypermutation critically depend on the function of activation-induced cytidine deaminase (AID). Rare variants in its gene AICDA have been reported to cause autosomal recessive AID deficiency (autosomal hyper-IgM syndrome type 2 (HIGM2)). Exome sequencing a multicase Finnish family with an HIGM2 phenotype identified rare, homozygous, variant (c.416T>C, p.(Met139Thr)) gene, found be significantly enriched population compared other populations...
Nuclear factor κ light-chain enhancer of activated B cells (NF-κB) family evolutionarily conserved transcription factors are involved in key cellular signaling pathways. Previously, hypogammaglobulinemia and common variable immunodeficiency (CVID)-like phenotypes have been associated with NFKB1 variants loss-of-function reported as the most monogenic cause for CVID among Europeans. Here, we describe a Finnish cohort carriers consisting 31 living subjects six different families carrying five...
SUMMARY The congenital rubella syndrome (CRS) is associated with increased risk for diabetes and thyroid disease. However, the mechanisms by which virus may cause these diseases are poorly characterized. Previous studies were carried out before modern immunological methods available. present study aimed at evaluating whether autoimmune involved in pathogenesis analysing antibodies to biochemically characterized autoantigens. incidence of clinical diabetes, disease, coeliac disease related...
Background. The mechanisms leading to abnormal immune regulation in type 1 diabetes and allergic diseases may be partly overlapping. If so, these should co-occur more often than expected. We investigated this phenomenon two contrasting socio-economic environments, Finland Russian Karelia.Methods. screened 413 Finnish children (of whom 147 had diabetes) 244 Karelian (132 for total immunoglobulin E (IgE) levels specific IgE against birch, cat, egg albumen. In addition we analysed...
<i>Background:</i> An increase in the prevalence of allergic conditions has been documented Finland, correlating with diminishing <i>Helicobacter pylori</i> infections. We investigated whether sensitisation still continues and correlates <i>H. <i>Methods:</i> The sera from 958 pregnant women 1983, 1989, 1995 2001 were analysed for presence antibodies against pylori</i>. In addition, allergen-specific IgE total levels measured....
Background Immunocompromised patients shed SARS-CoV-2 for extended periods, but to our knowledge person-to-person transmission from late shedding has not been reported.