A5087372327- Hormonal and reproductive studies
- Pharmacological Effects and Assays
- Cardiac Ischemia and Reperfusion
- Inflammasome and immune disorders
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Pharmacology and Obesity Treatment
- Pain Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Heme Oxygenase-1 and Carbon Monoxide
- Lipid metabolism and disorders
- Helicobacter pylori-related gastroenterology studies
- Redox biology and oxidative stress
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Protein Kinase Regulation and GTPase Signaling
- Microbial Metabolic Engineering and Bioproduction
- Pulmonary Hypertension Research and Treatments
- Computational Drug Discovery Methods
- Genetic Associations and Epidemiology
University of South Florida
2020-2023
Harbin Medical University
2009-2022
First Affiliated Hospital of Harbin Medical University
2009-2022
Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome was emerged as marker of metabolic dysregulation. We revealed that age-related Sirtuin-1 (SIRT1) modulates cardiac metabolism medicated inflammatory response during ischemia and reperfusion (I/R) stress. hypothesize SIRT1 attenuates NLRP3 inflammasome-dependent inflammation pyroptosis myocardial I/R through modulation. C57BL/6J wild type (WT) mice, inducible cardiomyocyte specific knockout...
Acute myocardial infarction (AMI) continues as the main cause of morbidity and mortality worldwide. Interestingly, emerging evidence highlights role gut microbiota in regulating pathogenesis coronary heart disease, but few studies have systematically assessed alterations influence AMI patients. As one approach to address this deficiency, study composition fecal microflora was determined from Chinese patients links between clinical features functional pathways were assessed. Fecal samples 30...
Chronic heart failure (CHF) is the final outcome of almost all forms cardiovascular diseases, remaining main cause mortality worldwide. Accumulating evidence focused on roles gut microbial community in disease, but few studies have unveiled alterations and further directions microbiota severe CHF patients. Aimed to investigate this deficiency, fecal samples from 29 patients diagnosed with NYHA Class III-IV 30 healthy controls were collected then analyzed using bacterial 16S rRNA gene...
Diabetic dyslipidemia is a common condition in patients with Type 2 diabetes mellitus (T2DM).However, the increasing application of statins which mainly decrease low-density lipoprotein cholesterol (LDL-C) levels, clinical trials and meta-analysis showed clearly increase incidence new-onset DMs, partly due to genetic factors.To determine whether causal relationship exists between LDL-C T2DM, we conducted two-sample Mendelian Randomization (MR) analysis using variations as instrumental...
Sestrin2 (Sesn2) is a stress sensor for the mammalian target of rapamycin complex 1 (mTORC1) pathway. Aging impairs cardiac mTORC1 activation, thereby sensitizing heart to hypertrophy. C57BL/6 J young wild-type (young WT; 4-6 months), aged WT (24-26 and knockout mice (Y-Sesn2 KO; months) underwent transverse aortic constriction (TAC) pressure overload. Cardiac expression Sesn2 decreased with age. At 4 weeks after TAC, Y-Sesn2 KO exhibited larger hearts impaired function, compared mice....
Despite the importance of testosterone as a metabolic hormone, its effects on myocardial metabolism in ischemic heart remain unclear. Myocardial ischemia leads to remodeling, ultimately resulting ATP deficiency and cardiac dysfunction. In present study, replacement were assessed castrated rat infarction model established by ligating left anterior descending coronary artery 2 weeks after castration. The results real-time PCR Western blot analyses showed that peroxisome proliferator-activated...
Oxidative stress participates in numerous myocardial pathophysiological processes and is considered a therapeutic target for ischemia heart failure. Guanxintai (GXT), traditional Chinese medicine, commonly used to treat cardiovascular disease on account of its beneficial physiological activities, such as dilating coronary arteries, inhibiting platelet aggregation, reducing the serum lipid content. However, antioxidative properties GXT potential underlying mechanisms remain be established. In...
Testosterone deficiency is present in a certain proportion men with chronic heart failure (CHF). Low testosterone levels American and European patients CHF lead to the high mortality readmission rates. Interestingly, this relationship has not been studied Chinese patients. To end, 167 underwent clinical laboratory evaluations associated determinations of levels. Total (TT) sex hormone-binding globulin were measured by chemiluminescence or immunoassays assays free (FT) calculated, Based upon...
The interactions among proteins and genes are extremely important for cellular functions. Molecular at protein or gene levels can be used to construct interaction networks in which the interacting species categorized based on direct functional similarities. Compared with limited experimental techniques, various computational tools make it possible analyze, filter, combine data get comprehensive information about biological pathways. By efficient way of integrating findings discovering PPIs...