A5090504612- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- RNA modifications and cancer
- Neuroscience and Neural Engineering
- Cellular transport and secretion
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cell Image Analysis Techniques
John Brown University
2023-2024
Brown University
2022-2024
Allen Institute for Brain Science
2024
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it thus critical to determine the factors contribute functional diversity synapses. We investigated contributions voltage-gated calcium channel (VGCC) abundance, spatial organization, subunit composition synapse among between synapses formed by two closely related Drosophila glutamatergic motor neurons with distinct neurotransmitter...
Nervous system function rests on the formation of functional synapses between neurons. We have identified TRMT9B as a new regulator synapse and in Drosophila. has been studied for its role tumor suppressor is one two metazoan homologs yeast tRNA methyltransferase 9 (Trm9), which methylates wobble uridines. Whereas Trm9 homolog ALKBH8 ubiquitously expressed, enriched nervous system. However, absence animal models, TRMT9B's remained unstudied. Here, we generate null alleles find it acts...
ABSTRACT Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it thus critical to determine the factors contribute functional diversity synapses. We investigated contributions voltage-gated calcium channel (VGCC) abundance, spatial organization, subunit composition synapse among between synapses formed by two closely related Drosophila glutamatergic motor neurons with distinct...
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it thus critical to determine the factors contribute functional diversity synapses. We investigated contributions voltage-gated calcium channel (VGCC) abundance, spatial organization, subunit composition synapse among between synapses formed by two closely related Drosophila glutamatergic motor neurons with distinct neurotransmitter...
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it thus critical to determine the factors contribute functional diversity synapses. We investigated contributions voltage-gated calcium channel (VGCC) abundance, spatial organization, subunit composition synapse among between synapses formed by two closely related Drosophila glutamatergic motor neurons with distinct neurotransmitter...
Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and responsive communication in neural circuits. In this study, we investigated the contributions voltage-gated calcium channels (VGCCs) to synaptic at two closely related Drosophila glutamatergic motor neurons, one low-and high-P r . We find VGCC levels are highly predictive heterogeneous release probability among individual active zones (AZs) low-or inputs, but not between neuronal subtypes. Underlying...
Abstract Nervous system function relies on the formation and of synaptic connections between neurons. Through a genetic screen in Drosophila for new conserved genes, we identified CG42261/Fid/ TRMT9B as negative regulator synaptogenesis. has been studied its role tumor suppressor multiple carcinomas is one two metazoan homologs yeast tRNA methyltransferase 9 (Trm9), which methylates wobble uridines. Members expanded family methyltransferases are increasingly being associated with...