A5058771443- RNA modifications and cancer
- Metalloenzymes and iron-sulfur proteins
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related gene regulation
- Metal-Organic Frameworks: Synthesis and Applications
- Epigenetics and DNA Methylation
- Atomic and Subatomic Physics Research
- Morphological variations and asymmetry
- Genetics and Physical Performance
- Genetic diversity and population structure
- Evolution and Paleontology Studies
University of Wisconsin–Madison
2015-2024
Abstract Organisms on islands provide a revealing window into the process of adaptation. Populations that colonize often evolve substantial differences in body size from their mainland relatives. Although ecological drivers this phenomenon have received considerable attention, its genetic basis remains poorly understood. We use house mice (subspecies: Mus musculus domesticus) remote Gough Island to portrait rapid and extreme evolution. In just few hundred generations, evolved largest among...
Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA-modifying enzyme that methylates wobble uridines in subset tRNAs to modulate translation. Through methylation tRNA-selenocysteine, promotes selenoprotein synthesis and redox homeostasis. Pathogenic variants have been linked intellectual disability disorders the human population, but role nervous system unknown. vivo studies Drosophila , we show controls oxidative stress brain restrain...
Organisms on islands often undergo rapid morphological evolution, providing a platform for understanding mechanisms of phenotypic change. Many examples evolution involve the vertebrate skeleton. Although genetic basis skeletal variation has been studied in laboratory strains, especially house mouse Mus musculus domesticus, determinants natural populations remain poorly understood. We used mice living remote Gough Island-the largest wild record-to understand genetics nature. Compared to...
Nervous system function rests on the formation of functional synapses between neurons. We have identified TRMT9B as a new regulator synapse and in Drosophila. has been studied for its role tumor suppressor is one two metazoan homologs yeast tRNA methyltransferase 9 (Trm9), which methylates wobble uridines. Whereas Trm9 homolog ALKBH8 ubiquitously expressed, enriched nervous system. However, absence animal models, TRMT9B's remained unstudied. Here, we generate null alleles find it acts...
Abstract Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA modifying enzyme that methylates wobble uridines in specific tRNAs to modulate translation. Through methylation tRNA-selenocysteine, promotes selenoprotein synthesis and redox homeostasis. Pathogenic variants have been linked intellectual disability disorders the human population, but role nervous system unknown. vivo studies Drosophila , we show controls oxidative stress brain...
Abstract Nervous system function relies on the formation and of synaptic connections between neurons. Through a genetic screen in Drosophila for new conserved genes, we identified CG42261/Fid/ TRMT9B as negative regulator synaptogenesis. has been studied its role tumor suppressor multiple carcinomas is one two metazoan homologs yeast tRNA methyltransferase 9 (Trm9), which methylates wobble uridines. Members expanded family methyltransferases are increasingly being associated with...