A5007260924- Metal-Organic Frameworks: Synthesis and Applications
- Metalloenzymes and iron-sulfur proteins
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Biomedical Research and Pathophysiology
Brown University
2023-2024
Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA-modifying enzyme that methylates wobble uridines in subset tRNAs to modulate translation. Through methylation tRNA-selenocysteine, promotes selenoprotein synthesis and redox homeostasis. Pathogenic variants have been linked intellectual disability disorders the human population, but role nervous system unknown. vivo studies Drosophila , we show controls oxidative stress brain restrain...
Abstract Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA modifying enzyme that methylates wobble uridines in specific tRNAs to modulate translation. Through methylation tRNA-selenocysteine, promotes selenoprotein synthesis and redox homeostasis. Pathogenic variants have been linked intellectual disability disorders the human population, but role nervous system unknown. vivo studies Drosophila , we show controls oxidative stress brain...