A5030461461- Cerebrospinal fluid and hydrocephalus
- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Metalloenzymes and iron-sulfur proteins
- Metal-Organic Frameworks: Synthesis and Applications
- Spinal Dysraphism and Malformations
- Biochemical effects in animals
- Advanced Drug Delivery Systems
- Spinal Fractures and Fixation Techniques
- Olfactory and Sensory Function Studies
- Bee Products Chemical Analysis
- Animal Diversity and Health Studies
- Intracerebral and Subarachnoid Hemorrhage Research
Brown University
2023-2024
Xidian University
2024
University of Virginia
2024
Columbia University
2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Providence College
2023
Rhode Island Hospital
2023
Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA-modifying enzyme that methylates wobble uridines in subset tRNAs to modulate translation. Through methylation tRNA-selenocysteine, promotes selenoprotein synthesis and redox homeostasis. Pathogenic variants have been linked intellectual disability disorders the human population, but role nervous system unknown. vivo studies Drosophila , we show controls oxidative stress brain restrain...
Tear stability decreases with increasing age and the same signs of instability are exacerbated dry eye. Meibum lipid compositional changes provide insights into biomolecules responsible for tear film instability. was collected from 69 normal donors ranging in 0.6 to 68 years age. Infrared spectroscopy used measure meibum phase transition parameters. Nuclear magnetic resonance saturation. Increasing human hydrocarbon chain unsaturation related a decrease order, cooperativity, temperature. The...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> Symptoms of normal pressure hydrocephalus (NPH) are sometimes refractory to shunt placement, with limited ability predict improvement for individual patients. We evaluated an MRI-based artificial intelligence method post-shunt NPH symptom improvement. <h3>MATERIALS METHODS:</h3> patients who underwent magnetic resonance imaging (MRI) prior placement at a single center (2014–2021) were identified. Twelve-month in modified Rankin Scale (mRS),...
A series of epidemiological studies have shown the limited life expectancy patients suffering from idiopathic normal pressure hydrocephalus (iNPH). In most cases, comorbid medical conditions are cause death, rather than iNPH. Though it has also been that shunting improves both quality and lifetime. We sought to investigate utility Charlson comorbidity index (CCI) for improved preoperative risk-benefit assessment shunt surgery in individual iNPH cases. 208 shunted cases were prospectively...
Abstract Post-transcriptional modification of RNA regulates gene expression at multiple levels. ALKBH8 is a tRNA modifying enzyme that methylates wobble uridines in specific tRNAs to modulate translation. Through methylation tRNA-selenocysteine, promotes selenoprotein synthesis and redox homeostasis. Pathogenic variants have been linked intellectual disability disorders the human population, but role nervous system unknown. vivo studies Drosophila , we show controls oxidative stress brain...
INTRODUCTION: Cognitive and affective dysfunction in Chiari Malformation Type I (CM1) patients are well-documented, but often rely on extensive neuropsychological tests. METHODS: Symptomatic CM1 considering surgical decompression were assessed by a board-certified neuropsychologist using the 105-point CNRS (N = 87) 10-task CCAS 23), as well full battery 24: Wechsler Full Scale IQ, Digit Span, Coding; WRAML Finger Windows; DKEFS Trail Making; verbal list learning; Grooved Pegboard)....
Purpose: To test if camel milk affects glucose-induced opacity in organ cultured rat and human lenses. Methods: Whole lenses were various media containing either 55 mM glucose, milk, or a combination of both glucose milk. Some neither moiety to establish control. Absorbance spectra measured daily using visible/ultraviolet light spectrometer. Lens opacities graded by blinded grader from photographs taken daily. Aldose reductase activity, catalase glutathione receptor for advanced glycation...