A5083716095- Aquaculture Nutrition and Growth
- Epigenetics and DNA Methylation
- Reproductive biology and impacts on aquatic species
- Aquaculture disease management and microbiota
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Fish Ecology and Management Studies
- Liver physiology and pathology
- Child Nutrition and Water Access
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Folate and B Vitamins Research
- Animal Genetics and Reproduction
- Polyamine Metabolism and Applications
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Dementia and Cognitive Impairment Research
- Radiopharmaceutical Chemistry and Applications
- Ultrasound in Clinical Applications
- Pancreatic function and diabetes
- Hepatitis B Virus Studies
Norwegian Institute of Marine Research
2018-2024
Cambridge University Press
2022
New York University Press
2022
Martin Luther University Halle-Wittenberg
2012-2013
London Postgraduate Medical and Dental Education
1987
Abstract Micronutrient status of parents can affect long term health their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a model system to examine morphological, molecular and epigenetic changes in mature offspring that experienced one-carbon (1-C) Zebrafish were fed diet sufficient, or marginally deficient 1-C nutrients (folate, vitamin B12, B6, methionine, choline), then mated. Offspring livers underwent histological...
Micronutrients (vitamins and minerals) have been less well studied compared to macronutrients (fats, proteins, carbohydrates) although they play important roles in growth, metabolism, maintenance of tissues. Hence, there is growing interest understand the influence micronutrients across various aspects nutritional research. In last two decades, aquaculture feeds shifted containing more plant-based materials meet increasing demand maintain sustainability industry. A recent whole life cycle...
Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins and methionine, is essential for the healthy growth development Atlantic salmon (
This study explores the effect of high dietary arachidonic acid (ARA) levels (high ARA) compared with low ARA (control) on general metabolism using zebrafish as model organism. The fatty composition today's 'modern diet' tends towards higher n-6 PUFA in relation to n-3 PUFA. Low n-3:n-6 ratio is a health concern, give rise eicosanoids and PG, which are traditionally considered pro-inflammatory, especially when derived from ARA. Juvenile fed high-ARA diet for 17 d had lower whole-body low-ARA...
Diet has been shown to influence epigenetic key players, such as DNA methylation, which can regulate the gene expression potential in both parents and offspring. Diets enriched omega-6 deficient omega-3 PUFAs (low dietary omega-3/omega-6 PUFA ratio), have associated with promotion of pathogenesis diseases humans other mammals. In this study, we investigated impact increased intake arachidonic acid (ARA), a physiologically important PUFA, on 2 generations zebrafish. Parental fish were fed...
Feeding plant-based diet through smoltification of Atlantic salmon requires verification the optimal level 1C nutrients. Here, we fed diets containing three different surplus amounts nutrients; methionine, cobalamin (vitamin B12), pyridoxine B6) and folic acid during 6 weeks in fresh water, smoltification, followed by 3 months on-growing period salt water. The were to fish dispersed triplicate tanks throughout experiment. Mean start body weight was 32 g. Dietary methionine levels 6.7, 9.2...
DNA methylation has an important role in intergenerational inheritance. An increasing number of studies have reported evidence germline inheritance induced by nutritional signals mammals. Vitamins and minerals as micronutrients contribute to growth performance vertebrates, including Atlantic salmon (Salmo salar), also a epigenetics environmental factors that alter status. It is understand whether the paternal diet can influence offspring through alterations signatures male germ cells.Here,...
The Atlantic salmon aquaculture industry relies on adjustments of female broodstock spawning season to meet the demand for delivery embryos outside natural season. Earlier results from zebrafish have shown that parental micronutrient status program offspring metabolism. Therefore, main hypothesis this study was investigate if out-of-season (off-season) (spawning in June, land-based recirculation systems) and their deviate when compared normal Both seasons were fed same diet starved...
Disproportionate high intake of n-6 polyunsaturated fatty acids (PUFAs) in the diet is considered as a major human health concern. The present study examines changes hepatic gene expression pattern adult male zebrafish progeny associated with levels PUFA arachidonic acid (ARA) parental diet. generation (F0) was fed which either low (control) or ARA (high ARA). Progenies both groups (F1) were given control No differences body weight found between within stages F0 F1 generation. Few...
Atlantic salmon (Salmo salar) breeding companies depend on changing light, temperature and feeding regimes to achieve new generations outside the natural spawning season. However, there have been few conducted trials reported that studied whether this shift affects important traits. We test an induced of two months earlier or later than normal season nutritional status (folate, methionine, vitamin B12, B6, free amino acids, N-metabolites lipids) in broodstock liver muscle levels same...
A moderate surplus of the one carbon (1C) nutrients methionine, folic acid, vitamin B6 and B12 above dietary recommendations for Atlantic salmon has shown to improve growth reduce hepatosomatic index in on-growing saltwater period when fed throughout smoltification. Metabolic properties molecular mechanisms determining improved are unexplored. Here, we investigate metabolic transcriptional signatures skeletal muscle taken before after smoltification acquire deeper insight into pathways...
Atlantic salmon aquaculture relies on continuous supply of high quality eggs. Broodfish nutrition and manipulation ovulation time (photoperiod temperature) are key factors. The optimum feeding period with broodfish diet has not been investigated before. present study examined how (9 vs. 17 months) interacted (early (Nov), normal (Dec), late (Feb)) broodstock egg production capacity in two-sea-winter female (~12 kg). All groups were fed until June 2021 when they transferred to tanks starved...
Abstract Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins and methionine, is essential for the healthy growth development Atlantic salmon ( Salmo salar ). However, recent shift towards non-fish meal diets in aquaculture has led to need reassessments recommended micronutrient levels. Despite importance 1C performance various cellular regulations, molecular mechanisms affected by these dietary alterations are less understood. To investigate effect...
Etwa 80% der HCC entwickeln sich in Leberzirrhose bekannter Äthiologie (z.B. Hepatitis B, Alkoholtoxische Leberzirrhose, Hämochromatose, Tyrosinämie). Meist unklar ist die Hepatocarcinogenese nicht zirrhotischem Lebergewebe. Wir vergleichen vorliegenden Studie erstmals normales und HCC-Lebergewebe hinsichtlich klonaler Proliferationsbereiche. Als Marker hierfür Indikator für Häufigkeit von mtDNS-Veränderungen benutzen wir spezifische Mutationen mtDNS, innerhalb dieser Felder nachweisbar...