A5045455433- HIV/AIDS Research and Interventions
- Malaria Research and Control
- HIV/AIDS Impact and Responses
- HIV Research and Treatment
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Advanced Biosensing Techniques and Applications
- Biosimilars and Bioanalytical Methods
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- American Sports and Literature
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Advanced Proteomics Techniques and Applications
- CAR-T cell therapy research
- Biosensors and Analytical Detection
- Monoclonal and Polyclonal Antibodies Research
- Gambling Behavior and Treatments
- Complementary and Alternative Medicine Studies
- Brain Metastases and Treatment
- T-cell and Retrovirus Studies
- Molecular Biology Techniques and Applications
- Adolescent Sexual and Reproductive Health
- 3D Printing in Biomedical Research
Program for Appropriate Technology in Health
2024
St James's University Hospital
2024
University of Leeds
2024
U.S. President's Malaria Initiative
2020-2021
SeraCare Life Sciences (United States)
2005-2006
A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination.
Background. RTS,S/AS01 vaccine efficacy (VE) was previously shown to be lower in African adults than malaria-naive US adults, potentially due concurrent Plasmodium falciparum (Pf) infections. We investigated whether treatment of infection prior vaccination would lead improved VE and immunogenicity. Methods. A Phase 2b study Kenyan evaluated the RTS,S/AS01E conjunction with antimalarial chemopreventive drugs. Participants, grouped by baseline presence or absence Pf infections, were randomized...
Profiling immune responses induced by either infection or vaccination can provide insight into identification of correlates protection. Furthermore, profiling serological be used to identify biomarkers indicative exposure pathogens. Conducting such surveillance requires readout methods that are high-throughput, robust, and require small sample volumes. While the enzyme-linked immunosorbent assay (ELISA) is classical method for assessing responses, advent multiplex assays has significantly...
Abstract RTS,S/AS01 is an advanced pre-erythrocytic malaria vaccine candidate with demonstrated efficacy up to 86.7% in controlled human infection (CHMI) studies; however, reproducible immune correlates of protection (CoP) are elusive. To identify candidates humoral mediated protection, we measured antibody magnitude, subclass, and avidity for Plasmodium falciparum (Pf) circumsporozoite protein (CSP) by multiplex assays two CHMI studies varying RTS,S/AS01B dose timing regimens. Central...
BACKGROUNDThe mechanism(s) responsible for the efficacy of WHO-recommended malaria vaccine RTS,S/AS01 are not completely understood. We previously identified RTS,S vaccine-induced Plasmodium falciparum circumsporozoite protein-specific (PfCSP-specific) antibody measures associated with protection from controlled human infection (CHMI). Here, we tested protection-predicting capability these in independent CHMI studies.METHODSVaccine-induced total serum (immunoglobulins, Igs) and subclass...
ABSTRACT The World Health Organization recently recommended the programmatic use of R21/Matrix-M vaccine for Plasmodium falciparum malaria prevention in children living malaria-endemic areas. To determine its effects on humoral immunity, we conducted a proteomic analysis polyclonal IgG antibodies directed against NANP tetrapeptide circumsporozoite protein (CSP) which comprises vaccine’s core immunogen. In ten malaria-naïve adult volunteers, induced polarized anti-NANP repertoires, heavily...
Background Brain metastases (BrM) affect up to 60% of patients with metastatic melanoma and are associated poor prognosis. While combined immune checkpoint blockade programmed death-1 (PD-1) cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) demonstrates intracranial efficacy in a proportion melanoma, the responses rarely durable, particularly symptomatic BrM. The brain is an immune-specialized organ regulated differently periphery. Methods Using our previously established two-site model...
s: Abstracts for the 20th Annual Scientific Meeting of International Society Biological Therapy Cancer (Primary Authors are Italicized): IMMUNE MONITORING