A5066689668- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Cancer Research and Treatments
- Oral Health Pathology and Treatment
- Chemokine receptors and signaling
- Virus-based gene therapy research
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- Tissue Engineering and Regenerative Medicine
- Immune Response and Inflammation
- Electrospun Nanofibers in Biomedical Applications
- Antifungal resistance and susceptibility
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Oral and gingival health research
- Streptococcal Infections and Treatments
- Head and Neck Cancer Studies
- Cell Adhesion Molecules Research
- Fungal Infections and Studies
- Proteoglycans and glycosaminoglycans research
- Salivary Gland Tumors Diagnosis and Treatment
University of Sheffield
2016-2025
Insigneo
2024
University of Minho
2022
University of Lisbon
2022
Universidade Estadual de Maringá
2020
Sheffield Hallam University
2011
University of Kent
2011
University of Liverpool
2011
Medway School of Pharmacy
2011
Mount Vernon Hospital
2011
TIE2-expressing monocytes/macrophages (TEM) are a highly proangiogenic subset of myeloid cells in tumors. Here, we show that circulating human TEMs already preprogrammed the circulation to be more angiogenic and express higher levels such genes as matrix metalloproteinase-9 (MMP-9), VEGFA, COX-2, WNT5A than TIE2(-) monocytes. Additionally, angiopoietin-2 (ANG-2) markedly enhanced activity increased their expression two enzymes: thymidine phosphorylase (TP) cathepsin B (CTSB). Three...
Abstract Angiopoietins 1 and 2 bind to Tie-2 expressed on endothelial cells regulate vessel stabilization angiogenesis. Tie-2+ monocytes have been shown be recruited experimental tumors where they promote tumor In this study, we show that 20% of CD14+ human blood express Tie-2, these coexpress CD16 (FcγRIII) are predominantly CD34 negative. Ang-2 is up-regulated by in malignant inflamed tissues, so our finding a chemoattractant for macrophages, suggests it may help recruit their distribution...
Previous studies in the K14-HPV/E2 mouse model of cervical carcinogenesis demonstrated that infiltrating macrophages are major source matrix metalloproteinase 9 (MMP-9), a metalloprotease important for tumor angiogenesis and progression. We observed increased expression macrophage chemoattractant, CCL2, its receptor, CCR2, concomitant with influx MMP-9 expression. To study role CCL2-CCR2 signaling tumorigenesis, we generated CCR2-deficient mice. Cervixes CCR2-null mice contained...
Angiopoietin 2 (ANGPT2) is a proangiogenic cytokine whose expression often upregulated by endothelial cells in tumors. Expression of its receptor, TIE2, defines highly subpopulation myeloid circulation and tumors called TIE2-expressing monocytes/macrophages (TEMs). Genetic depletion TEMs markedly reduces tumor angiogenesis various models, emphasizing their essential role driving progression. Previously, we demonstrated that ANGPT2 augments the genes, potent immunosuppressive cytokine, IL-10,...
Abstract Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites mice. To achieve this, magnetically label with super-paramagnetic iron oxide nanoparticles apply pulsed field gradients...
Polymersomes have the potential to encapsulate and deliver chemotherapeutic drugs into tumor cells, reducing off-target toxicity that often compromises anticancer treatment. Here, we assess ability of pH-sensitive poly 2-(methacryloyloxy)ethyl phosphorylcholine (PMPC)- 2-(diisopropylamino)ethyl methacrylate (PDPA) polymersomes agents for effective combinational therapy. Polymersome uptake encapsulated healthy normal oral cells head neck squamous cell carcinoma (HNSCC) was measured in two...
New therapies are required to target hypoxic areas of tumors as these sites highly resistant conventional cancer therapies. Monocytes continuously extravasate from the bloodstream into where they differentiate macrophages and accumulate in areas, thereby opening up possibility using cells vehicles deliver gene therapy otherwise inaccessible sites. We describe a new cell-based method that selectively targets an oncolytic adenovirus prostate tumors. In this approach, were cotransduced with...
We have developed a method for creating C3A liver spheroids and demonstrated cellular polarisation, zonation as well increased liver-specific functionality more predictive toxicological response compared to standard 2D models.
Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are chronic inflammatory conditions often characterised by erosive and/or painful oral lesions that have a considerable impact on quality of life. Current treatment necessitates the use steroids in form mouthwashes, creams or ointments, but these ineffective due to inadequate drug contact times with lesion. Here we evaluate performance novel mucoadhesive patches for targeted delivery. Electrospun polymeric were produced their...
Candidalysin is a cytolytic peptide toxin secreted by Candida albicans hyphae and has significantly advanced our understanding of fungal pathogenesis. critical for mucosal C infections known to activate epithelial cells induce downstream innate immune responses that are associated with protection or immunopathology during oral vaginal infections. Furthermore, candidalysin activates the NLRP3 inflammasome causes cytolysis in mononuclear phagocytes. However, role driving systemic unknown.