A5083276407- Catalytic C–H Functionalization Methods
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Oxidative Organic Chemistry Reactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Catalytic Alkyne Reactions
- Click Chemistry and Applications
- Asymmetric Hydrogenation and Catalysis
- Cancer therapeutics and mechanisms
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Catalytic Cross-Coupling Reactions
- Analytical Chemistry and Chromatography
- Microbial Natural Products and Biosynthesis
- Biochemical and Molecular Research
- HIV/AIDS Research and Interventions
- Computational Drug Discovery Methods
- Radical Photochemical Reactions
- X-ray Diffraction in Crystallography
- Alkaloids: synthesis and pharmacology
- Sulfur-Based Synthesis Techniques
- Synthesis and Biological Evaluation
- Synthesis and biological activity
Fudan University
2015-2025
Shanxi University of Finance and Economics
2022
Southerners on New Ground
2021
University of South Florida
2016
Second Military Medical University
2004
Stability and reactivity have been recognized as some critical issues for gold(I) catalysts. Such can be well-circumvented by anchoring the complex onto backbones of porous organic polymer (POP) followed coordination with a triazole ligand illustrated in present work via series gold(I)-catalyzed reactions. In this strategy, 1,2,3-triazole was used special "X-factor" to avoid formation solid AgCl involved typical gold-activation processes. The catalyst could readily recycled without loss...
A method to transform anilines 1‐azaspiro[4.5]decanes via oxidative dearomatization and palladium‐catalyzed aza‐[3+2] cycloaddition with vinylcyclopropanes was reported. The reaction showed broad substrate compatibility. Moreover, an asymmetric version of the preliminarily explored.
An efficient asymmetric synthesis of atorvastatin calcium has been achieved from commercially available diethyl 3-hydroxyglutarate through a novel approach that involves an organocatalytic enantioselective cyclic anhydride desymmetrization to establish C(3) stereogenicity and cyanide-free assembly C7 amino type side chain via C5+C2 strategy as the key transformations.
Abstract A series of novel diarylpyrimidines (DAPYs) with a ketone hydrazone substituent on the methylene linker between pyrimidine nucleus and aryl moiety at C‐4 position were synthesized, their antiviral activity against human immunodeficiency virus (HIV)‐1 in MT‐4 cells was evaluated. Most compounds this class exhibited excellent wild‐type HIV‐1, EC 50 values range 1.7–13.2 n M . Of these compounds, 2‐bromophenyl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone ( 9 k ) displayed most potent...
Abstract 2‐Alkynylanilines are attractive starting materials in indole synthesis because of their ready availability. Herein, a one‐pot stepwise procedure is reported for efficient construction multisubstituted oxocino[4,3,2‐ cd ]indoles from 2‐alkynylanilines and 2‐alkynylbenzaldoximes. The method comprises the oxidative dearomatization 2‐alkynylanilines, silver‐catalyzed [3+3] cycloaddition with 2‐alkynylbenzaldoximes, subsequent thermal radical skeletal rearrangement aromatization.
Dearomatization provides numerous possibilities for the development of new transformative modes aromatic compounds. A conceptually novel metal-free multicomponent domino reaction dearomatized products 2-alkynylanilines is developed. The involves secondary amine-mediated transimination with α-amino nitriles and subsequent aromatization-triggered cascade rearrangement, nucleophilic cyclization, retro-Strecker reaction. This process provided a practical method rapid synthesis polyfunctionalized...
A simple method for rapid synthesis of 4-alkylindoles from 2-alkynylanilines was reported. The protocol involves an oxidative dearomatization and aromatization triggered regioselective alkyl migration. range groups including linear, branched, or cycloalkyl can be introduced into the C4 position indole.
Abstract The formation of carbon–carbon bonds through the functionalization aromatic carbon–nitrogen is a highly attractive synthetic strategy in synthesis molecules. In this paper, we report novel bond reaction by using simple dearomatization strategy. Through process para ‐substituted anilines serve as potential aryl source construction range functionalized molecules, such quaternary carbon centers, α‐keto esters, and aldehydes.
Insertion of atoms into aromatic carbon-nitrogen bonds is an appealing method for the synthesis nitrogen-containing molecules and it has advantage availability abundance anilines. However, direct cleavage challenging due to particularly inert stable nature these bonds. Here we report a formal, enantioselective one-carbon insertion bond via aromaticity dissembly-reconstruction process directly convert anilines chiral α-branched benzylic amines. The involves oxidative dearomatization...
A dearomatization strategy has been developed for the efficient construction of vertically expanded five-ring fused benzofurans from ortho-alkynylphenols and ortho-alkynylarylaldimines. The stepwise procedure comprises a dearomatization-induced silver-catalyzed [3 + 2] cycloaddition followed by an aromatization-triggered ytterbium-catalyzed rearrangement.
An iodobenzene-catalyzed oxidative rearrangement of 2-allylanilines was developed. This process involves an ortho-oxidative dearomatization mediated by the in situ generated iodine(III) compound and a subsequent aromatization-triggered reaction, leading to formation functionalized indolin-3-ylmethanols with high diastereoselectivities.