A5015212924- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Curcumin's Biomedical Applications
- Free Radicals and Antioxidants
- Catalytic Cross-Coupling Reactions
- Photochemistry and Electron Transfer Studies
- Synthesis and Catalytic Reactions
- Gut microbiota and health
- Biochemical effects in animals
- Chemical Synthesis and Analysis
- Tryptophan and brain disorders
- Oxidative Organic Chemistry Reactions
- Catalytic Alkyne Reactions
- Alzheimer's disease research and treatments
- Photosynthetic Processes and Mechanisms
- Epigenetics and DNA Methylation
- Prion Diseases and Protein Misfolding
- Antioxidant Activity and Oxidative Stress
- Synthetic Organic Chemistry Methods
- Computational Drug Discovery Methods
- Trace Elements in Health
- Photodynamic Therapy Research Studies
- Radical Photochemical Reactions
- Genetic Associations and Epidemiology
Zhengzhou University
2023-2025
Jiangxi Science and Technology Normal University
2013-2025
Center for Drug Evaluation and Research
2024
Ministry of Education of the People's Republic of China
2023-2024
WuXi AppTec (China)
2024
Shijiazhuang Tiedao University
2023
Shandong University of Technology
2012-2022
Dezhou University
2015-2021
Waterborne Environmental (United States)
2019
Nanyang Technological University
2013-2018
Alzheimer’s disease (AD) is a neurodegenerative brain and the most common form of dementia. In recent years, many studies indicated association gut microbiota changes with metabolic diseases. However, AD has not been investigated. The present study aims to compare in APP/PS1 transgenic mice C57/Bl6 wild-type (WT) by pyrosequencing V3 V4 regions bacterial 16S ribosomal RNA genes. 3-, 6-, 8-month-old WT were used explore effects age on microbiota. First, results that impaired spatial learning...
Lysine specific demethylase 1 (LSD1), a transcriptional modulator that represses or activates target gene expression, is overexpressed in many cancer and causes imbalance the expression of normal networks. Over two decades, numerous LSD1 inhibitors have been reported, especially some which entered clinical trials, including eight irreversible (TCP, ORY-1001, GSK-2879552, INCB059872, IMG-7289, ORY-2001, TAK-418, LH-1802) reversible (CC-90011 SP-2577). Most demonstrated enhanced efficacy...
Without detours: Oxidative catalysis mediated by N-heterocyclic carbenes (NHCs) enables the direct β-carbon functionalization of saturated aldehydes (see scheme). The reaction proceeds through two sequential oxidative steps to generate α,β-unsaturated triazolium ester equivalents as formal Michael acceptors, which react with 1,3-diketones and β-ketone esters in an enantioselective manner. As a service our authors readers, this journal provides supporting information supplied authors. Such...
Curcumin, the major active component of turmeric (Curcuma longa), is widely used as a spice and food-coloring agent, also exhibits multiple biological activities. However, curcumin has poor systemic bioavailability its pharmacology remains to be elucidated. Owing high concentration in gastrointestinal tract after oral administration, we hypothesize that it may exert regulative effects on gut microbiota. We investigated administration microbiota C57BL/6 mice found significantly affected...
Abstract Curcumin is a natural product with multiple biological activities and numerous potential therapeutic applications. However, its poor systemic bioavailability fails to explain the potent pharmacological effects hinders clinical application. Using experimental theoretical approaches, we compared curcumin degradation products for against Alzheimer’s disease (AD), including superoxide anion radical (O 2 .– )-scavenging activity, Aβ fibrils (fAβ) formation-inhibiting enzymatic inhibition...
Abstract A convenient photoredox‐catalyzed defluorinative trifluoromethylation of α ‐trifluoromethyl alkenes and gem ‐difluoroalkenes is developed. The reactions proceeded efficiently via trifluoromethyl radical addition followed by β ‐fluorine elimination process, providing a new entry to multifluorinated in moderate good yields with excellent stereoselectivity. magnified image
// Xiao Yu Wu 1,* , Hao Xu 2,* Zhen Feng 1 Che Chen Jia Yun Liu Guan Nan Xue Quan Yao Fu Kun Gang Li 3 and Liang Shen 4 Department of Surgical Oncology, Affiliated Hospital Nanjing University Traditional Chinese Medicine, Nanjing, China 2 Division Gastrointestinal Surgery, General The First Affiliated Medical University, Jiangsu Cancer Hospital, Laboratory Biotechnology Biological Resource Utilization in Universities Shandong, College Life Science, Dezhou Dezhou, Shandong Province, * These...
Abstract The catalytic functionalization of alkenes is among the most important and powerful methods for construction two new bonds through cleavage π bonds, which widely used numerous complex organic molecules. Recently, strategy that involves directing groups‐assisted regioselective has found great synthetic application value, achievements have been made in unactivated alkynes. This Minireview summarizes recent progress transition metal‐catalyzed alkynes assisted by bidentate groups with...
Combined Lewis acid, consisting of two or more acids, sometimes shows unique catalytic ability, and it may promote reactions which could not be catalyzed by any the acids solely. On other hand, development efficient methods for facile synthesis cyclobutenes densely functionalized decalins is an attractive target synthetic chemists due to their versatile utilities widespread occurrence in natural products. Herein, we wish report method assembly decalin skeletons through In(tfacac)3-TMSBr...
Alzheimer’s disease (AD) is the main form of dementia and has a steadily increasing prevalence. As both oxidative stress metal homeostasis are involved in pathogenesis AD, it would be interesting to develop dual function agent, targeting two factors. Curcumin, natural compound isolated from rhizome Curcuma longa, an antioxidant can also chelate ions. Whether complexes curcumin with ions possess neuroprotective effects not been evaluated. Therefore, present study was designed investigate...