A5101729370- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Cellular transport and secretion
- Microtubule and mitosis dynamics
- HIV Research and Treatment
- Sleep and related disorders
- Erythrocyte Function and Pathophysiology
- Diet and metabolism studies
- Sleep and Wakefulness Research
- Developmental Biology and Gene Regulation
- Monoclonal and Polyclonal Antibodies Research
- Studies on Chitinases and Chitosanases
- Nutritional Studies and Diet
- Zebrafish Biomedical Research Applications
- Biocrusts and Microbial Ecology
- Neuroinflammation and Neurodegeneration Mechanisms
- CRISPR and Genetic Engineering
- Consumer Attitudes and Food Labeling
- 3D Printing in Biomedical Research
- Tardigrade Biology and Ecology
- Insect and Arachnid Ecology and Behavior
- Neuroscience and Neuropharmacology Research
- Poxvirus research and outbreaks
- Wnt/β-catenin signaling in development and cancer
- Endoplasmic Reticulum Stress and Disease
University of Toronto
2001-2025
Public Health Ontario
2025
McGill University
2022-2023
Ted Rogers Centre for Heart Research
2020-2021
Dana-Farber Cancer Institute
2006-2008
Harvard University
2007-2008
Axis elongation is a conserved process in which the head-to-tail or anterior-posterior (AP) axis of an embryo extends. In Drosophila, cellular rearrangements drive elongation. Cells exchange neighbours by converging into transient multicellular vertices resolve through assembly new cell interfaces parallel to AP axis. We found that elongate pulses correlated with periodic contractions surrounding cells. Inhibiting actomyosin contractility globally, specifically cells around vertices,...
α-catenin is a key protein of adherens junctions (AJs) with mechanosensory properties. It also acts as tumor suppressor that limits tissue growth. Here we analyzed the function Drosophila α-Catenin (α-Cat) in growth regulation wing epithelium. We found different α-Cat levels led to differential activation Hippo/Yorkie or JNK signaling causing overgrowth degeneration, respectively. can modulate Yorkie-dependent through recruitment Ajuba, negative regulator Hippo AJs but mechanism independent...
Abstract The sarco-endoplasmic reticulum (SR/ER) plays an important role in the development and progression of many heart diseases. However, aspects its structural organization remain largely unknown, particularly cells with a highly differentiated SR/ER network. Here, we report cardiac enriched, membrane protein, REEP5 that is centrally involved regulating cellular stress responses myocytes. In vitro depletion mouse myocytes results destabilization luminal vacuolization along decreased...
Nutrition claims aim to highlight key attributes in foods and assist consumers make informed dietary choices. Consumers generally perceive products with related lower sugars content as being healthier. Food manufacturers also use these reformulation action response consumer demands government policies. A cross-sectional analysis of baked goods breakfast cereals the Canadian marketplace was conducted, focusing on sugars-related nutrient (i.e., "no added sugars," "lower/reduced "sugar-free")...
Epithelial cells often leave their tissue context and ingress to form new cell types or acquire migratory ability move distant sites during development tumor progression. Cells lose apical membrane epithelial adherens junctions ingression. However, how factors that organize apical-basal polarity contribute ingression is unknown. Here, we show the dynamic regulation of Crumbs complex crucial for normal neural stem endocytosis recycling allow occur in a timeframe. During early ingression, its...
Immunization against smallpox (variola virus) with Dryvax, a live vaccinia virus (VV), was effective, but now safety is major concern. To overcome this issue, subunit vaccines composed of VV envelope proteins from both forms infectious virions, including the extracellular enveloped virion (EV) protein B5, are being developed. However, since B5 has 23 amino acid differences compared its B6 variola homologue, might be better choice for such strategy. Therefore, we properties using panel...
In emerging epithelial tissues, cells undergo dramatic rearrangements to promote tissue shape changes. Dividing remain interconnected via transient cytokinetic bridges. Bridges are cleaved during abscission and currently, the consequences of disrupting in developing epithelia not well understood. We show that Rab GTPase Rab25 localizes near midbodies likely coordinates through endomembrane trafficking epithelium zebrafish gastrula epiboly. maternal-zygotic Rab25a Rab25b mutant embryos,...
The lateral entorhinal cortex (LEC) is an essential component of the brain circuitry supporting long-term memory by serving as interface between hippocampus and neocortex. Dysfunction LEC affects sensory coding in hippocampus, leading to a view that provides with highly processed information. It remains unclear, however, how modulates neural processing neocortical regions. To address this point, we pharmacologically inactivated male rats during temporal associative learning task examined its...
Abstract Epithelial cells often leave their tissue context and ingress to form new cell types or acquire migratory ability move distant sites during development tumor progression. Cell lose apical membrane epithelial adherens junctions ingression. However, how factors that organize apical-basal polarity contribute ingression is unknown. Here, we show the dynamic regulation of Crumbs complex crucial for normal neural stem endocytosis recycling allow occur in a timeframe. During early...
Abstract In emerging epithelial tissues, cells undergo dramatic rearrangements to promote tissue shape changes. Dividing remain interconnected via transient cytokinetic bridges. Bridges are cleaved during abscission and currently, the consequences of disrupting in developing epithelia not well understood. We show that Rab GTPase, Rab25, localizes near midbodies likely coordinates through endomembrane trafficking epithelium zebrafish gastrula epiboly. maternal-zygotic Rab25a Rab25b mutant...