A5034786772- Genetics, Bioinformatics, and Biomedical Research
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Animal Genetics and Reproduction
- Advanced Biosensing Techniques and Applications
<title>Abstract</title> Advances in genomic medicine have accelerated the identification of mutations disease- associated genes, but pathogenicity many remains unknown, hindering their use diagnostics and clinical decision-making. Predictive AI models been generated to combat this issue, current tools display low accuracy when tested against functionally validated datasets. We show that integrating detailed conformational data extracted from molecular dynamics simulations (MDS) into advanced...
The nematode worm C. elegans is widely used in basic and translational research. creation of transgenic strains by injecting DNA constructs into the worm's gonad an essential step many research projects. This paper describes fabrication use a minimalist microfluidic chip for performing microinjections. immobilized tight-fitting microchannel, one sidewall which thin elastomeric membrane through injection pipet penetrates to reach worm. neither broken nor clogged passing membrane, reseals when...