A5079138288- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Mast cells and histamine
- interferon and immune responses
- Connexins and lens biology
- Chromatin Remodeling and Cancer
- Eosinophilic Disorders and Syndromes
- Protein Tyrosine Phosphatases
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- ATP Synthase and ATPases Research
- Acute Lymphoblastic Leukemia research
- Advanced biosensing and bioanalysis techniques
- Sphingolipid Metabolism and Signaling
- Spaceflight effects on biology
Weizmann Institute of Science
2018-2021
University of Milano-Bicocca
2018-2020
Abstract Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified several myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we demonstrate primary leukemic cells cell lines that mutated causes significant increase mitochondrial activity, ROS production, Histone H2AX phosphorylation, ultimately driving the increased accumulation of new mutations. We also show phosphoethanolamine, metabolic product ETNK1, negatively controls activity through...
Summary ETV6‐RUNX1 (E/R) fusion gene, arising in utero from translocation t(12;21)(p13:q22), is the most frequent alteration childhood acute lymphoblastic leukemia (ALL). However, E/R insufficient to cause overt since it generates a clinically silent pre‐leukemic clone which persists bone marrow but fails out‐compete normal progenitors. Conversely, cells show increased susceptibility transformation following additional genetic insults. Infections/inflammation are accredited triggers for...
Abstract Atypical chronic myeloid leukemia (aCML) is a clonal disorder belonging to the myelodysplastic/myeloproliferative syndromes. About 13% of aCML cases carry somatic mutations in ETNK1 gene, encoding for H243Y, N244S, and G245V substitutions. We previously showed that cause decreased catalytic activity enzyme. Despite this evidence however, their oncogenic role remained largely unexplained. Since essential synthesis phosphatidylethanolamine (PE) given PE one most abundant phospholipids...