A5103064954- Force Microscopy Techniques and Applications
- Material Dynamics and Properties
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
- Polymer Surface Interaction Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Rheology and Fluid Dynamics Studies
- Carbon Dioxide Capture Technologies
- Fluorine in Organic Chemistry
- Organophosphorus compounds synthesis
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Nanopore and Nanochannel Transport Studies
- Catalysts for Methane Reforming
- Quinazolinone synthesis and applications
- Electron and X-Ray Spectroscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Synthesis of heterocyclic compounds
- Advanced Chemical Sensor Technologies
- Polydiacetylene-based materials and applications
- Diffusion and Search Dynamics
- Sulfur-Based Synthesis Techniques
- Phase Equilibria and Thermodynamics
- Bioactive Compounds and Antitumor Agents
- X-ray Spectroscopy and Fluorescence Analysis
Centre National de la Recherche Scientifique
2010-2016
University of California, San Diego
2014-2016
Institut Charles Sadron
2010-2016
Sejong University
2007-2016
The University of Texas at Austin
2015
La Jolla Bioengineering Institute
2014
National Institutes of Health
2013
National Cancer Institute
2013
Frederick National Laboratory for Cancer Research
2013
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2013
Human APOBEC3A (A3A) is a single-domain cytidine deaminase that converts deoxycytidine residues to deoxyuridine in single-stranded DNA (ssDNA). It inhibits wide range of viruses and endogenous retroelements such as LINE-1, but it can also edit genomic DNA, which may play role carcinogenesis. Here, we extend our recent findings on the NMR structure A3A report structural, biochemical cell-based mutagenesis studies further characterize A3A's nucleic acid binding activities. We find binds ssRNA,...
Single-molecule studies in which a mechanical force is transmitted to the molecule of interest and molecular extension or position monitored as function time are versatile tools for probing dynamics protein folding, stepping motors, other biomolecular processes involving activated barrier crossing. One complication interpreting such studies, however, fact that typical size probe (e.g., dielectric bead optical tweezers atomic microscope tip/cantilever assembly) much larger than itself, so...
Adsorption data for CH4, C2H6, C2H4, H2, and N2 on the zeolite 5A adsorbent (W. R. Grace & Davision Co.) were obtained at 293 K, 303 313 K. The pressure range studied was 0 to 2 MPa, which covers operating in swing adsorption (PSA) units. Experimental correlated by Langmuir Langmuir−Freundlich (L−F) equations several isotherm models. This paper compares L−F equations. Despite relative simplicity of both isotherms, experimental fit very well. In addition, Clausius−Clapeyron equation employed...
Helically coiled filaments are a frequent motif in nature. In situations commonly encountered experiments helices squeezed flat onto two dimensional surfaces. Under such 2-D confinement form "squeelices" - peculiar conformations often resembling looped waves, spirals or circles. Using theory and Monte-Carlo simulations we illuminate here the mechanics unusual statistical of confined show that their fluctuations can be understood terms moving interacting discrete particle-like entities...
Torsionally stressed DNA plays a critical role in genome organization and regulation. While the effects of torsional stresses on naked have been well studied, little is known about how these propagate within chromatin affect its organization. Here we investigate behavior nucleosome arrays by means Brownian dynamics simulations coarse-grained model chromatin. Our reveal strong dependence response rotational phase angle Ψ0 between adjacent nucleosomes. Extreme values lead to asymmetric,...
We study the motion of a single stiff semiflexible filament length S through an array topological obstacles. By means scaling arguments and two-dimensional computer simulations, we show that chain kinetics follows reptation picture, albeit with kinetic exponents (for central monomer) different from those for flexible reptation. At early times when constraints are irrelevant, is anisotropic dynamics free filament. After entanglement time tau(e) transverse modes equilibrated under constraints,...
Stained end-grafted DNA molecules about $20\text{ }\text{ }\ensuremath{\mu}\mathrm{m}$ long are scraped away and stretched out by the spreading front of a bioadhesive vesicle. Tethered biotin ligands bind vesicle bilayer to streptavidin substrate, stapling DNAs into frozen confinement paths. Image analysis stapled gives access, within optical resolution, local stretching values individual swept front, provides evidence self-entanglements.
The kinetic properties of a semiflexible chain subject to an external force are investigated using scaling arguments and computer simulations. By monitoring the mean square displacements in principal axes, authors found that anisotropic dynamic fluctuations go through several distinct regimes characterized by two different exponents corresponding transverse longitudinal fluctuations. When is applied at one end, tension propagates gradually other leading nonuniform profiles. At short times,...
The relaxation of single grafted semiflexible chains freely rotating around the grafting point is investigated by means two dimensional computer simulations and scaling arguments. Both free surrounded topological obstacles are considered. We compute autocorrelation end-to-end vector for whole chain terminal sections various lengths. Our results relevant star polymers with stiff arms or branched moving in an array obstacles.
The nucleosome represents the basic unit of eukaryotic genome organization, and its conformational fluctuations play a crucial role in various cellular processes. Here we provide insights into flipping transition by computing free-energy landscape as function linking number orientation using density-of-states Monte Carlo approach. To investigate how energy is affected presence neighboring nucleosomes chromatin fiber, also compute for dinucleosome array. We find that mononucleosome bistable...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract The anilines (I) are N‐methoxymethylated upon treatment with formaldehyde (II) and sodium methoxide (III).
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”