A5063486195- Multicomponent Synthesis of Heterocycles
- Cardiac Ischemia and Reperfusion
- Pharmacological Receptor Mechanisms and Effects
- Chemical Synthesis and Reactions
- Chemical Reaction Mechanisms
- Synthesis and biological activity
- Heavy Metals in Plants
- Electrochemical Analysis and Applications
- Exercise and Physiological Responses
- Bee Products Chemical Analysis
- Energy and Environment Impacts
- Craniofacial Disorders and Treatments
- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Connective tissue disorders research
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Effects of Exercise
- Fuel Cells and Related Materials
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Eicosanoids and Hypertension Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular and exercise physiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical synthesis and alkaloids
Universidade Federal do Rio Grande
2016-2022
University of Rio Grande and Rio Grande Community College
2019
Polyhydroquinolines (PHQs) are the unsymmetrical Hantzsch derivatives of 1,4-dihydropyridines with several biological applications. In this work, new fatty 2- and 3-substituted PHQ from different acids alcohol feedstocks were synthesized at good yields via a four-component reaction (4CR). The antioxidant activities PHQs investigated using three methods. experiments showed that compounds derived 2-nitrobenzaldehyde palmitic (C16:0) oleic (C18:1) chains better activity. This revealed combining...
The intensity of exercise determines the metabolic pathway and energetic substrate that is spent. Our study sought to identify effects different intensities swimming on myocardial oxidative status blood lipid profile. Eighty Wistar rats (male female) submitted a regimen (low, LS; moderate, MS; or high, HS) for 16 weeks. Samples myocardium from left ventricle were collected determine profiles status. Reactive oxygen species (ROS) antioxidant capacity against peroxyl radicals (ACAP),...
Abstract Objective: To report a case of successful bone-anchored hearing aid implantation in an adult patient with type III osteogenesis imperfecta, which is commonly regarded as contraindication to this procedure. Case report: A 45-year-old man imperfecta presented mixed loss. There was mild sensorineural component both ears, air–bone gap between 45 and 50 dB HL. He implanted aid. The audiological outcome good, no complications good implant stability (as measured by resonance frequency...
Nifedipine is a calcium channel blocker dihydropyridine that has been used in the treatment of hypertension. The production reactive species and overload are main contributors to myocardial ischemia-reperfusion (I / R) injury. We investigated ability novel dihydropyridines (DHPs) improve effect protecting against injury induced by ischemia reperfusion cardioblasts when compared nifedipine. Forty three DHPs were created varying fatty chains derived from palmitic acid, stearic acid oleic acids...
From the synthesis of 43 lipophilic dihydropyridines, aim this study was to verify whether new dihydropyridines have calcium channel affinity using coupling studies and determine antihypertensive antioxidant properties, as well toxicology toxicity nifedipine three compounds, were chosen from previous results.The animals treated for 56 days, 28 days with N (ω) -nitro-L-arginine methyl ester induce hypertension, then another di- hydropyridine standard drug nifedipine. Throughout treatment had...
The effects of the aqueous extract Ilex paraguariensis (Ip) and flavonoid quercetin were tested during induction in vivo myocardial ischemia/ reperfusion Rattus norvegicus. antioxidant power chemically determined. experimental groups were: control, ischemia/reperfusion induction, Ip oral treatment, treatment ischemia /reperfusion, ischemia/reperfusion. Rats anesthetized with sodium thiopental xylazine via intraperitoneal injection subsequently underwent 15 minutes followed by reperfusion....
Abstract In this study, three fatty dihydropyridines, were tested for their anti-hypertensive and cardioprotective properties. Dihydropyridines 2c, 8c, 9a contain the oleic chain nitro unit, chlorine palmitic respectively. For experiments, animals treated with N(ω)-nitro-L-arginine methyl ester to induce hypertension after new dihydropyridine compounds standard drug nifedipine. Then, heart was removed subjected global ischemia reperfusion. Analyses of cardiac parameters performed monitor...
Abstract Purpose In this study, three fatty dihydropyridines were synthesized and tested for their antihypertensive cardioprotective properties. Dihydropyridines 2c , 8c 9a contain the oleic chain nitro unit; chlorine palmitic unit, respectively. Methods For experiments, animals treated with N ω -nitro-L-arginine methyl ester (L-NAME) to induce hypertension after new dihydropyridine (DHPs) compounds standard drug nifedipine. Then, animals’ heart was removed subjected global ischemia...
Objective : In this work, rats isolated hearts were infused EPA before the ischemia period and during reperfusion for available get well in parameter relatives to redox reactions. Methods The effect of was tested on induced reperfusion, treatment occurred at different times (ischemia or reperfusion). Antioxidant capacity against peroxyl radicals, glutathione cysteine ligase activity, concentration, lactate dehydrogenase, creatine kinase concentration analyzed. Results Hearts treated with...