A5079985016- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Signaling Pathways in Disease
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Peptidase Inhibition and Analysis
- Toxin Mechanisms and Immunotoxins
- Insect symbiosis and bacterial influences
- Advanced Thermodynamic Systems and Engines
- Mast cells and histamine
- Renin-Angiotensin System Studies
- Congenital Anomalies and Fetal Surgery
- Viral gastroenteritis research and epidemiology
- Caveolin-1 and cellular processes
- Synthesis and Biological Evaluation
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Cancer Cells and Metastasis
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
Experimental Medicine and Biology Institute
2021-2024
University of Buenos Aires
2014-2021
Instituto de Química y Fisicoquímica Biológicas
2014-2021
Institute of Astronomy and Space Physics
2019
National Agricultural Technology Institute
2016
Abstract T cells are central to the adaptive immune response against Trypanosoma cruzi infection. In chronic Chagas disease (CCD), circulating parasite-specific memory show reduced functionality and increased expression of inhibitory receptors as a result persistent antigenic stimulation. This phenotype has been linked progression cardiac pathology, whereas presence polyfunctional shows association with therapeutic success. this study, we demonstrate that T. cruzi–specific human CD4+ can be...
Antigen-specific T cells are central to the adaptive immune response against T. cruzi infection and underpin efficacy of on-going vaccine strategies. In this context, present study focuses on T-cell assays that define parasite-specificity basis upregulation TCR stimulation-induced surface markers. For purpose, we tested different dual marker combinations (OX40, CD25, CD40L, CD137, CD69, PD-L1, CD11a, CD49d, HLA-DR, CD38) reliably identify activated CD4+ CD8+ populations from PBMCs chronic...