A5047094581- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Physiological and biochemical adaptations
- Developmental Biology and Gene Regulation
- Cancer Research and Treatments
University of Washington
2022
A fundamental step in regeneration is rapid growth to replace lost tissue. Cells must generate sufficient lipids, nucleotides, and proteins fuel cell division. To define metabolic pathways underlying regenerative growth, we undertake a multimodal investigation of reprogramming Xenopus tropicalis appendage regeneration. Regenerating tissues have increased glucose uptake; however, inhibition glycolysis does not decrease Instead, funneled the pentose phosphate pathway (PPP), which essential for...
A fundamental step in appendage regeneration is rapid growth to replace lost tissue. Cells must generate sufficient lipids, nucleotides, and proteins fuel cell division. To define the metabolic pathways underlying regenerative growth, we undertook a multimodal investigation of reprogramming Xenopus tropicalis regeneration. We find that regenerating tissues have increased glucose uptake; however, glycolysis neither nor required for Instead, funneled pentose phosphate pathway (PPP), which...