A5006192970- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Health, Environment, Cognitive Aging
- Viral Infectious Diseases and Gene Expression in Insects
- Bioinformatics and Genomic Networks
- Biofuel production and bioconversion
- Polyamine Metabolism and Applications
- Gene Regulatory Network Analysis
- Metabolomics and Mass Spectrometry Studies
- Enzyme Catalysis and Immobilization
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Hydraulic flow and structures
- Hydrology and Sediment Transport Processes
- Protein purification and stability
- Water Systems and Optimization
Ege University
2023
Chalmers University of Technology
2019-2021
Ankara University
2009-2017
Middle East Technical University
2006
An open-source, genome-scale human metabolic model and a web portal to explore the are generated.
Genome-scale metabolic models (GEMs) are used extensively for analysis of mechanisms underlying human diseases and malfunctions. However, the lack comprehensive high-quality GEMs model organisms restricts translational utilization omics data accumulating from use various disease models. Here we present a unified platform that covers five major animals, including Mouse1 (Mus musculus), Rat1 (Rattus norvegicus), Zebrafish1 (Danio rerio), Fruitfly1 (Drosophila melanogaster), Worm1...
BACKGROUND Design principles of a fed-batch bioreactor system to fine-tune performance by increasing production and productivity are investigated. To enhance the in fermentation recombinant human growth hormone (rhGH) Bacillus subtilis, this work develops continuous feed stream (CFS) design method with parameters, cultivation time switch batch- operation, so called transition time, tT, specific rate, μ. RESULTS Based on batch-bioreactor data for rhGH B. subtilis (scoC−) carrying...
This work aims to conduct flux balance analysis of serine alkaline protease overproduction in Bacillus subtilis using enzyme-constrained genome scale model and compare the results with fluxes obtained from a smaller, bioreaction-based model. Fluxes enzyme constraint were calculated CobraToolbox v3.0 compared those for specific growth rate zero. The active reaction number first increased then remained constant constrained SAP synthesis decrease both models. TCA cycle was models, but lower...
Bu calismada, su alma agzina hava girisi ve tabakali akiskan ortaminda istenilen akiskanin cekilmesine (alinmasina) ait kritik batiklik su-hava su-yag-hava ortamlarinda deneyler yapilarak incelenmis Kritik Kuresel Kuyu Yuzeyi (KKKY) teorisi ile kontrol edilmistir. Tabakali ortaminda, ust tabakada yer alan (serbest cevrinti cokuntusunu doldurarak) henuz giris yaptigi andaki agzi tabaka akiskaninin alt siniri (ara yuzey) arasindaki dusey mesafe “kritik batiklik” olarak adlandirilir. Askidaki...