Since 1967, spinal cord stimulation (SCS) has been used to manage chronic intractable pain of the trunk and limbs. Compared traditional high-intensity, low-frequency (<100 Hz) SCS that is thought produce paresthesia relief by stimulating large myelinated fibers in dorsal column (DC), low-intensity, high-frequency (10 kHz) demonstrated long-term without generation paresthesia. To understand this paresthesia-free analgesic mechanism 10 kHz SCS, we examined whether at intensities below sensory...

Postural sway changes often reflect functional impairments in adults with chronic low back pain (LBP). However, there is a gap understanding how these individuals adapt their postural strategies to maintain stability.

Abstract Background The unilateral stance test, measured by the center of pressure (COP), has been widely used to identify balance deficits. However, there is a critical gap in understanding specific COP thresholds on postural stability adults with fear falling (FOF). Aims To investigate normalized time, which was defined as ratio time spent within boundaries total test duration, under different visual conditions and between without FOF. Methods Twenty-one older FOF 22 control subjects...

To understand the theoretical effects of pulse width (PW) programming in spinal cord stimulation (SCS), we implemented a mathematical model electrical fields and neural activation SCS to gain insight into PW programming. The computational was composed finite element for structure properties, coupled with nonlinear double-cable axon predict nerve excitation different myelinated fiber sizes. Mathematical modeling suggested that mediolateral lead position may affect chronaxie rheobase values,...

Chronic low back pain (LBP) impairs balance control due to deficits in sensory integration, yet limited research examines postural sway under varying visual conditions. This study assessed the effects of input on stability using normalized index, excursions, and contralateral toe-touch durations during repeated one-leg standing tasks. Thirty-two adults with LBP 40 subjects performed dominant limb a force plate. Outcome measures included Oswestry disability analog scale, excursions...

Visual conditions significantly influence fear of movement (FOM), which is a condition that impairs postural control and quality life (QOL). This study examined how visual sway velocity during repeated one-leg standing tasks explored the potential relationship between control, FOM, QOL in older adults with without FOM. Thirty-seven FOM 37 controls participated study. Postural was measured across three trials under both anteroposterior (AP) mediolateral (ML) directions. The groups...

ABSTRACT Background and Purpose Chronic low back pain (LBP) significantly impacts quality of life presents challenges in musculoskeletal health management. Effective sensory integration for balance control is crucial; however, the relationship between fall efficacy strategies individuals with LBP remains underexplored. This study aimed to evaluate strategy scores equilibrium indices across various Sensory Organization Test (SOT) conditions by comparing without chronic context efficacy....

New strategies for spinal cord stimulation (SCS) chronic pain have emerged in recent years, which may work better via different analgesic mechanisms than traditional low-frequency (e.g., 50 Hz) paresthesia-based SCS. To determine if 10 kHz and burst SCS waveforms might a similar mechanistic basis, we examined whether these at intensities ostensibly below sensory thresholds would modulate dorsal horn (DH) neuronal function neuron type-dependent manner. By using an vivo electrophysiological...

Background: The McGrath videolaryngoscope (VL) provides excellent laryngoscopic views, but directing an endotracheal tube can be difficult, and thus the routine use of a stylet is recommended. goal this study to determine appropriate angle (60° vs 90°) when using VL by comparing time intubation (TTI). Methods: One hundred forty patients aged 19 70 years (American Society Anesthesiologists classification I or II) who required tracheal for elective surgery were randomly allocated 1 2 groups,...

Since 1967, spinal cord stimulation (SCS) has been used to manage chronic intractable pain of the trunk and limbs. Low-intensity, paresthesia-free, 10 kHz SCS demonstrated statistically- clinically-superior long-term relief compared conventional SCS. proposed operate via selective activation inhibitory interneurons in superficial dorsal horn. In contrast, 40 Hz is presumed largely column fiber activation. To determine if these mechanisms may be implemented synergistically, we examined effect...

In spinal cord stimulation (SCS), concordance of stimulation-induced paresthesia over painful body regions is a necessary condition for therapeutic efficacy. Since patient pain patterns can be unique, common configuration the placement two leads in parallel dorsal epidural space. This construct provides flexibility steering current mediolaterally column to achieve better pain-paresthesia overlap. Using mathematical model with an accurate fiber diameter distribution, we studied ability dual...

Flatfoot, a foot deformity characterized by the collapse of arch, significantly impacts an individual's balance and stability. This study explored postural adjustments sway excursions in individuals with without flatfoot using Time-in-Boundary method. method assessed relative stability exploring various center pressure radius thresholds during three trials single-leg stance. We observed significant interactions threshold levels (F = 4.37, p 0.04) normalized stable times 7.64, 0.01),...

Kilohertz high-frequency spinal cord stimulation (kHF-SCS) is a rapidly advancing neuromodulatory technique in the clinical management of chronic pain. However, precise cellular mechanisms underlying kHF-SCS-induced paresthesia-free pain relief, as well neural responses within circuits, remain largely unexplored. In this study, using novel preparation, we investigated impact varying kilohertz frequency SCS on dorsal horn neuron activation. Employing calcium imaging isolated slices, found...