A5101762740- Bone and Joint Diseases
- Saffron Plant Research Studies
- Bone health and treatments
- Orthopedic Infections and Treatments
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Pharmacogenetics and Drug Metabolism
- Kruppel-like factors research
- Biochemical and Molecular Research
- Drug-Induced Hepatotoxicity and Protection
Affiliated Zhongshan Hospital of Dalian University
2012-2020
Abstract Background Long-term use of steroid may lead to osteonecrosis the femoral head (ONFH). Mechanical stress help bone formation and remodeling. This study aimed probe role mechanical in recovery rats. Methods Rat models with ONFH were induced by steroid. Rats subjected different levels (weight-bearing training), then morphology density rats measured. The mRNA protein OPG/RANK/RANKL axis rat assessed. Gain- loss-of function experiments OPG performed identify its following implement. ex...
Abstract Objectives The aim of this work was to identify the uridine glucuronosyltransferase (UGT) isoforms involved in metabolism broad-spectrum antiviral drug arbidol. Methods A human liver microsome (HLM) incubation system employed catalyse formation arbidol glucuronide. glucuronidation activity commercially recombinant UGT towards screened. combination kinetic analysis and chemical inhibition study used determine arbidol's glucuronidation. Key findings glucuronide detected when incubated...