A5029797196- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Heat shock proteins research
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Neonatal Respiratory Health Research
- Reproductive Physiology in Livestock
- Immune Response and Inflammation
- Reproductive tract infections research
- Immune Cell Function and Interaction
- Adrenal Hormones and Disorders
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Autophagy in Disease and Therapy
- Pelvic floor disorders treatments
- Birth, Development, and Health
- Xenotransplantation and immune response
- Blood groups and transfusion
- Urticaria and Related Conditions
- Urinary Tract Infections Management
- Dermatology and Skin Diseases
- Hormonal Regulation and Hypertension
- Tendon Structure and Treatment
- Genital Health and Disease
Cornell University
2011-2022
Weill Cornell Medicine
2016-2022
National University of Rosario
2005-2018
Instituto de Biología Molecular y Celular de Rosario
2016
Consejo Nacional de Investigaciones Científicas y Técnicas
2016
New York Hospital Queens
2006-2007
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2007
RELX Group (United States)
2007
Health and Human Development (2HD) Research Network
2007
Foundation for Ichthyosis and Related Skin Types
2007
The relationship between a localized genital tract humoral immune response to Chlamydia trachomatis and the presence of antisperm antibodies on surface motile spermatozoa in ejaculate was examined 227 asymptomatic male partners infertile couples with no history exposure C.trachomatis. Semen serum samples were assayed for immunoglobulin (Ig) A IgG C.trachomatis by enzyme-linked immunosorbent assay employing recombinant Chlamydia-specific lipopolysaccharide fragment (Medac, Hamburg, Germany),...
Lactic acid is the predominant present in vagina. We evaluated consequences of lactic acid, at physiological levels vagina, on cytokine responses peripheral blood mononuclear cells (PBMCs) obtained from 10 individuals presence or absence bacterial lipopolysaccharide. Preincubation PBMCs 15 mM before addition lipopolysaccharide resulted a 246% mean increase interleukin-23 (IL-23) secretion over that released alone (P=0.0068). The lipopolysaccharide-induced production tumor necrosis factor-α,...
Human papillomavirus (HPV) was detected in 17 (16.0%) of 106 patients undergoing treatment for IVF. papillomavirus-positive women had a decreased pregnancy rate (4 17, 23.5%) as compared with HPV-negative (51 89, 57.0%; P<.02).
ABSTRACT: Human seminal fluid, at low dilutions, prevented the binding of aggregated human IgG (AHG) to bull spermatozoa. Seminal fluids from vasectomized men were also inhibitory. Preincubation fluid with spermatozoa prior washing and addition AHG had no inhibitory effect, indicating that component was reacting directly AHG. fractionated by gel exclusion chromatography on Ultrogel AcA‐34, activity found in fractions corresponding a molecular weight 94,000. The this fraction stable boiling...
The T cell subpopulation bearing a receptor for the Fc fragment of IgM (T mu) or IgG gamma) were studied in 12 patients with active atopic dermatitis (AD) and elevated IgE (5678 I.U./ml +/- 1382) compared control group normal (33 17). Values total lymphocytes absolute relative numbers mu cells comparable both groups. However, AD had markedly reduced gamma levels, 1.8% 0.4%, normals, 10.5% 0.7% (p less than 0.001). also 29 7, 181 36 0.0005). This abnormality was not indicative allergic...
Background Streptococcus agalactiae (group B Streptococcus) is a bacterial pathogen that causes severe intrauterine infections leading to fetal morbidity and mortality. The pathogenesis of GBS infection in this environment poorly understood, part because we lack detailed understanding the adaptation growth amniotic fluid. To address knowledge deficit, characterized transcriptome grown human fluid (AF) compared it with rich laboratory medium. Methods was Todd Hewitt-yeast extract medium AF....
To evaluate the influence of lactic acid on immune mediator release from vaginal epithelial cells.The human cell line, VK2/E6E7, was cultured in presence or absence physiological concentrations acid, and viral Toll-like receptor 3 agonist, poly (inosinic acid:cytidylic acid). Supernatants were assayed by enzyme-linked immunosorbent assay (ELISA) for interleukin (IL)-1β, IL-6, IL-8, IL-23, transforming growth factor (TGF)-β secretory leukocyte protease inhibitor.Vaginal cells spontaneously...
Sera from 35 men were collected before and at timed intervals subsequent to vasectomy examined for the presence of (a) antibody reactive with human spermatozoa, (b) sperm-related antigen, (c) circulating immune complexes (CIC). Fewer than 10% ever positive antisperm antibodies. However, antigens elevated in sera 18, 26% mean 2 wk, mo, 4 mo postvasectomy, respectively. CIC detected some vasectomized by three different assays. The patients' precipitated polyethylene glycol, dissociated,...
The association between 60 kDa Chlamydia trachomatis heat shock protein (CHSP60) antibodies and the etiology outcomes of in vitro fertilization (IVF) is not well known.A retrospective study with a double-blind analysis follicular fluid from 253 IVF patients for IgG to CHSP60.The CHSP60 were detected 74.1% women without embryo implantation 47.9% 1-3 implantations per cycle (P = 0.0004). 69.5% tubal occlusion 49.7% other causes infertility 0.01). antibody detection was unrelated maternal age,...
Varying daily doses of a steroidal inhibitor 3β-hydroxysteroid dehydrogenase (2α-cyano-4,4,17α-trimethylandrost-5-en-17β-ol-3-one), were administered to pregnant rats on the 15 th 20th days gestation determine whether this could produce biological manifestations human disease associated with deficient activity enzyme. A single dose was also various critical periods for production these manifestations. Infants disorder have hyperplastic adrenal cortices in 3β-enzyme, incomplete masculine...