A5063676335- interferon and immune responses
- RNA regulation and disease
- SARS-CoV-2 and COVID-19 Research
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- RNA Research and Splicing
Insilicogen (South Korea)
2022
Seoul National University
2016
Significance Type I IFN signaling is the most important innate immune response induced by viral infection. However, it not completely known how components of type are spatiotemporally coordinated to elicit effective responses upon stimulation. We identified microtubule-associated protein 4 (MAP4) and butyrophilin 3A1 (BTN3A1) as novel regulators pathway triggered cytosolic nucleic acids. In acid stimulation, BTN3A1-mediated transport TANK-binding kinase 1 (TBK1) along microtubules...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has posed a serious threat to global public health. A novel vaccine made from messenger RNA (mRNA) been developed and approved for use at an unprecedented pace. However, increased risk of myocarditis reported after BNT162b2 mRNA vaccination due unknown causes. In this study, we used single-cell sequencing T cell receptor analyses peripheral blood mononuclear cells (PBMCs) describe, the first time, changes in immune...