A5038544366- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Multiple Sclerosis Research Studies
- Lymphatic System and Diseases
- Systemic Sclerosis and Related Diseases
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Family Support in Illness
- Complement system in diseases
- Advanced Breast Cancer Therapies
- RNA Research and Splicing
- Peripheral Neuropathies and Disorders
- Reproductive System and Pregnancy
- DNA Repair Mechanisms
- Erythrocyte Function and Pathophysiology
- Biomarkers in Disease Mechanisms
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- Prenatal Screening and Diagnostics
- RNA regulation and disease
- Genetic factors in colorectal cancer
Hunter Medical Research Institute
2016-2023
University of Newcastle Australia
2018-2023
Medical University of Lublin
2023
Hunter New England Local Health District
2021
Bond University
2016
Breast cancer is the most diagnosed malignancy in women, with over half a million women dying from this disease each year. In our previous studies, ∆40p53, an N‐terminally truncated p53 isoform, was found to be upregulated breast cancers, and high ∆40p53 : p53α ratio linked worse disease‐free survival. Although inhibits migration invasion, little known about role of regulating these metastasis‐related processes its contributing prognosis. The aim study assess invasion. A relationship between...
Abstract Our previous studies have shown that p53 isoform expression is altered in breast cancer and related to prognosis. In particular, a high ∆40p53:p53α ratio associated with worse disease-free survival. this manuscript, the influence of Δ40p53 p53α levels on response standard care DNA-damaging agents used treatment was investigated vitro. results revealed Δ40p53:p53α causes cells respond differently doxorubicin cisplatin treatments. overexpression significantly impairs cells’...
There is a paucity of knowledge concerning erythrocytes in the aetiology Multiple Sclerosis (MS) despite their potential to contribute disease through impaired antioxidant capacity and altered haemorheological features. Several studies have identified an abundance erythrocyte miRNAs variable profiles associated with states, such as sickle cell malaria. The aim this study was compare miRNA profile relapsing-remitting MS (RRMS) patients healthy sex- age-matched controls.Erythrocytes were...
TP53 mutations are associated with tumour progression, resistance to therapy and poor prognosis. However, in breast cancer, TP53′s overall mutation frequency is lower than expected (~25%), suggesting that other mechanisms may be responsible for the disruption of this critical suppressor. p53 isoforms known enhance or disrupt pathway activity cell- context-specific manners. Our previous study revealed isoform mRNA expression correlates clinicopathological features survival cancer account...
In breast cancer, p53 expression levels are better predictors of outcome and chemotherapy response than TP53 mutation. Several molecular mechanisms that modulate functions, including isoform expression, have been described, may contribute to deregulated activities worse cancer outcomes. this study, regulators the pathway were sequenced by targeted next-generation sequencing in a cohort 137 invasive ductal carcinomas associations between identified sequence variants, explored. The results...
Breast cancer-related lymphedema (BCRL) is a form of secondary that characterized by abnormal swelling one or both arms due to the accumulation lymph fluid in interstitial tissue spaces, resulting from obstruction lymphatic vessels surgery insults, radiotherapy, chemotherapy. Due multifactorial nature this condition, pathogenesis remains unclear and search for molecular factors associated with condition ongoing. This study aimed identify serum microRNAs adipokines BCRL. Blood was collected...
Abstract Background Multiple sclerosis is a demyelinating autoimmune disease, for which there no blood‐borne biomarker. Erythrocytes may provide source of such biomarkers as they contain microRNAs. MicroRNAs regulate protein translation through complementary binding to messenger RNA. As erythrocytes are transcriptionally inactive, their microRNA profiles be less susceptible variation. The aim this study was assess the biomarker potential erythrocyte microRNAs multiple and contribution...
The pathology of progressive multiple sclerosis (MS) is poorly understood. We have previously assessed DNA methylation in the CD4+ T cells relapsing-remitting (RR) MS patients compared to healthy controls and identified differentially methylated regions (DMRs) HLA-DRB1 RNF39. This study aimed investigate profiles patients. was measured two separate case/control cohorts using Illumina 450K/EPIC arrays data analysed with Chip Analysis Methylation Pipeline (ChAMP). Single nucleotide...
Abstract In breast cancer, dysregulated TP53 expression signatures are a better predictor of chemotherapy response and survival outcomes than mutations. Our previous studies have shown that high levels Δ40p53 associated with worse disease-free disruption p53-induced DNA damage in cancers. Here, we further investigated the vitro vivo implications cancer. We genes cell differentiation downregulated while those stem regulation upregulated invasive ductal carcinomas expressing Δ40p53. contrast...
Melanoma is the deadliest type of skin cancer and despite improvements in treatment outcomes, melanoma claimed 57,043 lives 2020. In most malignancies, p53 mutation rates are above 50% provide prognostic indications. However, where less than a quarter cases harbour mutation, significance tumour suppressor may be questioned. Instead, isoforms, which modulate p53's canonical function, greater clinical importance.The expression isoforms was evaluated 123 specimens by immunohistochemistry using...
<title>Abstract</title> In breast cancer, dysregulated<italic>TP53</italic>expression signatures are a better predictor of chemotherapy response and survival outcomes than<italic>TP53</italic>mutations. Our previous studies have shown that high levels Δ40p53 associated with worse disease-free disruption p53-induced DNA damage in cancers. Here, we further investigated the<italic>in vitro</italic>and<italic>in vivo</italic>implications expression cancer. We genes cell differentiation...