A5006080537- Dental Erosion and Treatment
- Dental materials and restorations
- Dental Health and Care Utilization
- Dental Anxiety and Anesthesia Techniques
- Oral microbiology and periodontitis research
- Temporomandibular Joint Disorders
- Fluoride Effects and Removal
- Endodontics and Root Canal Treatments
- Laser Applications in Dentistry and Medicine
- Dental Radiography and Imaging
- Dental Implant Techniques and Outcomes
- Dental Research and COVID-19
- Dental Trauma and Treatments
- Dermatologic Treatments and Research
- Bone and Dental Protein Studies
- Occupational health in dentistry
- Orthodontics and Dentofacial Orthopedics
- Bone Tissue Engineering Materials
- Salivary Gland Disorders and Functions
- Bacterial biofilms and quorum sensing
- Tattoo and Body Piercing Complications
- Pediatric health and respiratory diseases
- Oropharyngeal Anatomy and Pathologies
- Advanced Nanomaterials in Catalysis
- Textile materials and evaluations
Indiana University Health
2012-2024
Indiana University – Purdue University Indianapolis
2015-2024
University School
2010-2024
Indiana University
2006-2024
Indiana University Indianapolis
2015-2022
KU Leuven
2022
University of Hawaiʻi at Mānoa
2022
University of Alabama at Birmingham
2020
Faculty of Public Health
2010-2019
Indiana University School of Medicine
2017
Ferumoxytol is a nanoparticle formulation approved by the U.S. Food and Drug Administration for systemic use to treat iron deficiency. Here, we show that, in addition, ferumoxytol disrupts intractable oral biofilms prevents tooth decay (dental caries) via intrinsic peroxidase-like activity. binds within biofilm ultrastructure generates free radicals from hydrogen peroxide (H2O2), causing situ bacterial death cell membrane disruption extracellular polymeric substances matrix degradation. In...
Significance Dental caries remains an unresolved public health problem. The etiology is poorly understood, as the oral cavity harbors diverse communities of microorganisms. Using multiple imaging modalities on human teeth from patients with caries, we discovered a microbial community precisely arranged in corona-like architecture. Moreover, this organization mediated by pathogen Streptococcus mutans through production extracellular scaffold that directs positioning other microbes. We...
Since the currently available pH-cycling models do not differentiate anti-caries potential of dentifrices with low fluoride (F) concentration, two were developed and tested in present. Bovine enamel blocks subjected to treated F solutions containing from 70 280 mug F/mL order validate them terms dose-response effect. The also by evaluating Colgate Baby (500 F/g, as a dentifrice), Tandy (1,100 an active F-dentifrice) Crest positive control). Enamel mineral loss or gain was assessed surface...
The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour protects against different erosive challenges by orange juice. Subjects wore palatal appliances loaded with either enamel or dentin specimens. Pellicle was allowed to form, not (control), on surfaces of specimens intra-orally for 2 hrs before 0 10, 20, and 30 minutes’ duration. Specimens were randomly removed from after each challenge. Percentage surface...
Severe tooth decay has been associated with iron deficiency anemia that disproportionally burdens susceptible populations. Current modalities are insufficient in severe cases where pathogenic dental biofilms rapidly accumulate, requiring new antibiofilm approaches. Here, we show ferumoxytol, a Food and Drug Administration-approved nanoparticle formulation for treating deficiency, exerts an alternative therapeutic activity via the catalytic activation of hydrogen peroxide, which targets...
Since the use of bovine instead human dentine to evaluate cariogenic and anticariogenic substances is not well established, this in situ study was conducted. Eleven volunteers wore palatal acrylic devices containing 4 slabs (2 2 bovine). Sucrose solution (20%) dripped over all times a day, simulating challenge. Dentifrice slurries, fluoridated or not, were specified 3 day caries reduction. After 14 days, biofilm formed on collected for microbiological analysis. In dentine, mineral loss (ΔZ)...
Summary The aim of this study was to evaluate the effect different storage media upon surface micromorphology resin‐based restoratives. One resin‐modified glass–ionomer (Fuji II LC Improved), one polyacid‐modified composite resin (Dyract AP), microfilled (Durafill VS), and hybrid (Filtek Z250) were tested. For each material, 45 standardized cylindrical specimens randomly made. After 24 h, samples finished polished, their roughness measured obtain Ra (μm) baseline values (Bv). Fifteen...
The occurrence and progress of enamel demineralization may be reduced in the presence its reaction products, such as calcium. Therefore, this study hypothesis that lower erosive potential expected for calcium‐containing beverages was tested. Ten commercially available beverages, five with without calcium supplementation, were tested two phases. In first phase, pH, titratable acidity, concentrations (total ionic), phosphorus fluoride, analyzed. second ability test products to erode measured,...
This investigation was conducted in an attempt to clarify the role of organic matrix bovine dentine demineralisation by 1% citric acid. Dentine slabs (n = 15) were treated for 2 min with 10% sodium hypochlorite (NaOCl, a strong protein solvent), 2% glutaraldehyde (GDA, fixative) or deionised water (DIW, as negative control) prior each 5 periods 30 min. The mineral loss (ΔZ), lesion depth (LD) and surface (SL) determined after period demineralisation, transverse microradiography....
To investigate how the biofilm three-dimensional (3D) architecture influences in situ pH distribution patterns on enamel surface. Biofilms were formed human tooth presence of 1% sucrose or 0.5% glucose plus fructose. At specific time points, biofilms exposed to a neutral buffer mimic buffering saliva and subsequently pulsed with induce re-acidification. Simultaneous 3D mapping intact was performed using two-photon confocal microscopy. The surface mineral content characteristics examined...
Fungi and bacteria often engage in complex interactions, such as the formation of multicellular biofilms within human body. Knowledge about how interkingdom initiate coalesce into higher-level communities which functions different species carry out during biofilm remain limited. We found native-state assemblages Candida albicans (fungi) Streptococcus mutans (bacteria) with highly structured arrangement saliva from diseased patients childhood tooth decay. Further analyses revealed that...
Remineralization of eroded enamel by dentifrices containing similar sources/concentrations fluoride was investigated in situ. Fifty-three subjects completed a double-blind crossover study with 3 randomly assigned dentifrice treatments: placebo (0 ppm F, PD); reference (1,450 NaF, RD) and test NaF + 5% KNO(3), TD). Fluoride availability for each analyzed vitro standard tests (1-min release rate uptake). The wore palatal appliances holding bovine specimens previously vitro. Surface...
To evaluate the erosive potential of orange juice modified by food additives in enamel and dentine.Calcium lactate pentahydrate (CLP), xanthan gum (XG), sodium linear polyphosphate (LPP), pyrophosphate tetrabasic (PP), tripolyphosphate (STP) some their combinations were added to an juice. Pure a calcium-modified used as negative (C-) positive (C+) controls, respectively. In phase 1, 15 juices tested for using pH-stat analysis. 2, alone combination with good results 1 previous studies...