A5047226523- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Conducting polymers and applications
- Polymer composites and self-healing
- Advanced Sensor and Energy Harvesting Materials
- Silicone and Siloxane Chemistry
- Hydrogels: synthesis, properties, applications
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Supramolecular Chemistry and Complexes
University of Cambridge
2021-2024
Recent progress in the development of synthetic polymer networks has enabled next generation hydrogel-based machines and devices. The ability to mimic mechanical electrical properties human tissue gives great potential toward fields bioelectronics soft robotics. However, fabricating hydrogel devices that display high ionic conductivity while maintaining stretchability softness remains unmet. Here, we synthesize supramolecular poly(ionic) networks, which (>1500%), compressibility (>90%),...
Peptide dimerization is ubiquitous in natural protein conjugates and artificial self-assemblies. A major challenge systems remains achieving quantitative peptide heterodimerization, critical for next-generation biomolecular purification formulation of therapeutics. Here, we employ a synthetic host to simultaneously encapsulate an aromatic noncanonical l-perfluorophenylalanine-containing through embedded polar-π interactions, constructing unprecedented series heteropeptide dimers. To...
Molecular hinges are ubiquitous in both natural and artificial supramolecular systems. A major challenge to date, however, has been simultaneously achieving high thermodynamic kinetic stability. Here, we employ host-enhanced intramolecular charge-transfer interactions mediate entropy-favored complexation between a flexible AB2-type guest macrocyclic host, forming new type of molecular hinge with an ultrahigh picomolar binding affinity (Ka > 1012 M–1). This entropy-promoted modulates...