Trees, and their derivative products, have been used by societies around the world for thousands of years. Contemporary construction tall buildings from timber, in whole or part, suggests a growing interest potential building with wood at scale not previously attainable. As is only significant material that grown, we natural inclination good environment. But under what conditions this really case? The environmental benefits using timber are straightforward; although it product, large amount...

In recent years, significant evolutions have been made in applying nanotechnologies for prophylactic and therapeutic cancer vaccine design. However, the clinical translation of nanovaccines is still limited owing to their complicated compositions difficulties spatiotemporal coordination antigen-presenting cell activation antigen cross-presentation. Herein, a minimalist binary nanovaccine (BiVax) designed that integrates innate stimulating activity into carrier elicit robust antitumor...

The ability to mimic the activity of natural enzymes using supramolecular constructs (artificial enzymes) is a vibrant scientific research field. Herein, we demonstrate that cucurbit[7]uril (CB[7]) can catalyse Diels-Alder reactions for number substituted and unreactive N-allyl-2-furfurylamines under biomimetic conditions, without need protecting groups, yielding powerful synthons in previously unreported mild conditions. CB[7] rearranges substrate highly reactive conformation shields it...

Rational control of the cooperativity multiple noncovalent interactions often plays an important role in design and construction supramolecular self-assemblies materials, especially precision engineering. However, it still remains a challenge to through tuning hydrophobic effect. In this work, we demonstrate that binding cucurbit[8]uril(CB[8])-mediated homoternary complexes is strongly influenced by amphiphilicity guest molecule side groups on account interplay between both classical...

A 1:1 binding stoichiometry of a host–guest complex need not consist single host and guest. Diarylviologens containing electron-donating substituents complexed with cucurbit[8]uril (CB[8]) in exhibit abnormally large enthalpies compared to typical enthalpy changes observed for binary complexes. Here, several CB[8]-mediated complexes, which were previously reported as are verified be 2:2 quaternary complexes by combination isothermal titration calorimetry, 1H, NOESY, ROESY NMR, ion mobility...

Dimerisation of a wide range fluorophores through multiple CB[8] clampings leads to constrained intracomplex motion and distinct photophysical properties.

Phenyl-perfluorophenyl polar−π interactions have been revisited for the design and fabrication of functional supramolecular systems. The relatively weak associative (ΔG ≈ −1.0 kcal/mol) limited their use in aqueous self-assembly to date. Herein, we propose a strategy strengthen phenyl-perfluorophenyl by encapsulation within synthetic host, thus increasing binding affinity ΔG= −15.5 kcal/mol upon formation heteroternary complexes through social self-sorting. These were used as dynamic, yet...

Abstract The challenge of quantitatively forming self‐assembled heterodimers without other equilibrium by‐products is overcome through self‐sorting favored by the introduction designed shape‐complementary moieties. Such a supramolecular strategy based on cucurbit[8]uril‐directed dimerization further applied to generate hetero‐chromophore dimers quantitatively, leading efficient energy transfer (>85 %) upon photoexcitation.

Abstract In this Full Paper, we develop a novel approach for the generation of stable molecularly imprinted sites in polymeric films by combining layer‐by‐layer (LbL) technique and photochemical crosslinking layered structure. After photo‐crosslinking, show high reproducibility rapid loading unloading template molecules. Moreover, competitive adsorption molecules redox labels into film using electrochemical methods indicates that has higher affinity We believe may have some advantages over...

A tetra(aniline)-based cationic amphiphile, TANI-NHC(O)C5H10N(CH3)3(+)Br(-) (TANI-PTAB) was synthesized, and its emeraldine base (EB) state found to self-assemble into nanowires in aqueous solution. The observed self-assembly is described by an isodesmic model, as shown temperature-dependent UV-vis investigations. Linear dichroism (LD) studies, combined with computational modeling using time-dependent density functional theory (TD-DFT), suggests that TANI-PTAB molecules are ordered...

Supramolecular hyaluronic acid hydrogels formed <italic>via</italic> 2 : 1 homoternary complexes of coumarin and cucurbit[8]uril can reversibly toggle between physical covalent states.

Cucurbit[8]uril (CB[8]) mediated assembly of extended aryl viologens (EVs) into optically tunable dimers is reported for the first time. We show that modular design and synthesis a new class π-conjugated viologen derivatives with rigid aromatic or heteroaromatic bridging units as well electron donating molecular recognition motifs enable their self-assembly 2 : complexes CB[8]. The quantitative dimerization process involving these two components in an aqueous solution enables excimer-like...

Controlling the spatial and temporal behavior of peptide segments is essential in fabrication functional peptide-based materials nanostructures. To achieve a desired structure, complex sequence design often required, coupled with inclusion unnatural amino acids or synthetic modifications. Herein, we investigate structural properties 1:1 complexes between specific oligopeptides cucurbit[8]uril (CB[8]), inducing formation turns, by alteration sequence, tunable chirality. We also explore...

For artificial supramolecular architectures designed to mimic biological systems, achieving different pathway synthesis is challenging due the requirement of multiple stable and interconvertible intermediates. Here, we propose a novel “inner‐outer steric synergy” strategy investigate controllable engineering for specific structures. Firstly, three structures (Ring‐Pd2LA2, Bowl‐Pd2LA3 or Cage‐Pd2LA4) with interconversion properties were selectively formed by assembling externally modified...

For artificial supramolecular architectures designed to mimic biological systems, achieving different pathway synthesis is challenging due the requirement of multiple stable and interconvertible intermediates. Here, we propose a novel “inner‐outer steric synergy” strategy investigate controllable engineering for specific structures. Firstly, three structures (Ring‐Pd2LA2, Bowl‐Pd2LA3 or Cage‐Pd2LA4) with interconversion properties were selectively formed by assembling externally modified...

We introduce a class of supramolecular precursors, termed 'folda-bonders', which utilize macrocycles to fold and precisely align reactive groups, effectively acting as bonding facilitators. This design enables highly efficient, selective, mild 'click-like' reactions, making them particularly well-suited for the modular synthesis complex structures. In this study, we highlight versatility folda-bonders in one-pot aqueous chiral ring-in-ring complexes exhibiting torsion-induced circularly...

The size and substitution pattern of hydrotropic counteranions determine the aggregated structures cationic bolaamphiphiles.

Dialkylated melamine derivatives self-assemble with halogen acids into 2D organic microsheets in solvent through counterion bridged multiple hydrogen bonds as well electrostatic interactions and π–π stacking. Alkyl chains are introduced to suppress the growth a particular dimension, supplying general approach for fabrication of structures. Protonation is demonstrated be crucial factor formation assemblies. The assembly disassembly can reversibly controlled by alternating addition acid base....

Self-assembly of cationic bolaamphiphiles is usually reported to form one-dimensional (1D) or zero-dimensional (0D), rather than two-dimensional (2D) structures. Here we have found a facile counterion-directed structure switch for such amphiphilic moieties. 0D/1D structures formed by self-assembly can be converted into 2D planar simple counterion change tosylate. As indicated the single crystal and variable-temperature NMR studies, strong binding between tosylate counterions headgroups...

Abstract The ability to mimic the activity of natural enzymes using supramolecular constructs (artificial enzymes) is a vibrant scientific research field. Herein, we demonstrate that cucurbit[7]uril (CB[7]) can catalyse Diels–Alder reactions for number substituted and unreactive N ‐allyl‐2‐furfurylamines under biomimetic conditions, without need protecting groups, yielding powerful synthons in previously unreported mild conditions. CB[7] rearranges substrate highly reactive conformation...

Pseudo[2,3]rotaxanes have been successfully fabricated by the complexation of cucurbit[8]uril (CB[8]) macrocycles with extended viologen derivatives. Two design rules enable incorporation a third CB[8] onto recently reported pseudo[2,2]rotaxane. Incorporation macrocycle confines dimeric stacking chromophores into specific alignment, leading to effective electron-delocalisation along their long molecular axis.

Peptide dimerization is ubiquitous in natural protein conjugates and artificial self-assemblies. A major challenge systems remains achieving quantitative peptide heterodimerization, critical for next-generation biomolecular purification formulation of therapeutics. Here, we employ a synthetic host to simultaneously encapsulate an aromatic noncanonical l-perfluorophenylalanine-containing through embedded polar-π interactions, constructing unprecedented series heteropeptide dimers. To...

In this article, we have demonstrated a universal method for improving the stability of polyelectrolyte multilayer films by designing photoreactive polyanion as building block layer-by-layer (LbL) self-assembly. By grafting an azido group into poly(acrylic acid), synthesized polyanion, which can induce photo-crosslinking between and polymeric backbone under UV irradiation. Our results show that after photocross-linking, is greatly improved. Considering polyanion-bearing highly reactive,...