A5005625364- Neurobiology and Insect Physiology Research
- Physiological and biochemical adaptations
- Insect and Arachnid Ecology and Behavior
- Insect Utilization and Effects
- Adipose Tissue and Metabolism
- Plant and animal studies
- Muscle Physiology and Disorders
- Insect and Pesticide Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Hypoxia, and Metabolism
University of Copenhagen
2019-2024
Roskilde University
2013
Abstract Organisms adapt their metabolism and growth to the availability of nutrients oxygen, which are essential for development, yet mechanisms by this adaptation occurs not fully understood. Here we describe an RNAi-based body-size screen in Drosophila identify such mechanisms. Among strongest hits is fibroblast factor receptor homolog breathless necessary proper development tracheal airway system. Breathless deficiency results tissue hypoxia, sensed primarily context fat through HIF-1a...
Insect steroid hormones (ecdysteroids) are important for female reproduction in many insect species and required the initiation coordination of vital developmental processes. Ecdysteroids also adult male physiology behavior, but their exact function site synthesis remains unclear, although previous studies suggest that reproductive system may be source. We have examined expression profiles ecdysteroidogenic Halloween genes, during development adults flour beetle Tribolium castaneum. Genes...
Abstract Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although improving signaling is key to reversing diabetes, the multi-organ mechanisms regulating this process are poorly defined. Here, we screen secretome receptome in Drosophila identify hormonal crosstalk affecting diet-induced resistance obesity. We discover a complex interplay between muscle, neuronal, adipose tissues, mediated by Bone Morphogenetic Protein (BMP) hormone Bursicon, that enhances...