A5027059769- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Lymphatic System and Diseases
- Lymphatic Disorders and Treatments
- Plant Pathogenic Bacteria Studies
- Tumors and Oncological Cases
- Emergency and Acute Care Studies
- Renal and related cancers
- Legume Nitrogen Fixing Symbiosis
- Pleural and Pulmonary Diseases
- Congenital Anomalies and Fetal Surgery
- Health and Medical Studies
- dental development and anomalies
- Child and Adolescent Health
- Tracheal and airway disorders
- Systemic Sclerosis and Related Diseases
- Plant Parasitism and Resistance
- Marine Invertebrate Physiology and Ecology
- Medical Practices and Rehabilitation
- Venomous Animal Envenomation and Studies
- Congenital Diaphragmatic Hernia Studies
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
University of Bonn
2017-2022
University Hospital Bonn
2020-2022
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2019
Johannes Gutenberg University Mainz
2019
Life & Brain (Germany)
2017
University Hospital Frankfurt
2013
Goethe University Frankfurt
2013
Klinikum Rheine
2006
Non-syndromic cleft lip with or without palate (nsCL/P) is a common congenital facial malformation multifactorial etiology. Genome-wide association studies (GWASs) have identified multiple genetic risk loci. However, functional interpretation of these loci hampered by the underrepresentation in public resources systematic maps representative human embryonic development. To generate novel insights into etiology nsCL/P, we leveraged published GWAS data on nsCL/P as well available chromatin...
Nonsyndromic cleft lip with or without palate (nsCL/P) ranks among the most common human birth defects and has a multifactorial etiology. Human neural crest cells (hNCC) make substantial contribution to formation of facial bone cartilage are key cell type in terms nsCL/P Based on increasing evidence for role noncoding regulatory mechanisms nsCL/P, we investigated hNCC-expressed microRNAs (miRNA) development. First, conducted systematic analysis miRNAs expressed human-induced pluripotent stem...
The number of patients in German emergency departments has been rising for years. This means additional need staff and infrastructure hospitals.In this monocentric retrospective analysis the patient population central department (ZNA) at university hospital Frankfurt was investigated. Major symptoms, diagnoses with respect to diagnose-related groups modes admission have analyzed.During 3 months, a total 7376 presented ZNA. Analysis focused on 2186 referred internal medicine: most...
Abstract Background Nonsyndromic cleft lip with/without palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome‐wide significant risk loci, which explain less than 40% nsCL/P heritability. Studies show that some the hidden heritability explained by rare penetrant variants. Methods To identify new candidate genes, we searched for highly de novo variants (DNVs) in 50 patient/parent‐trios with low polygenic phenotype (discovery). We...
Non-syndromic cleft lip with/without palate (nsCL/P) is a highly heritable facial disorder. To date, systematic investigations of the contribution rare variants in non-coding regions to nsCL/P etiology are sparse. Here, we re-analyzed available whole-genome sequence (WGS) data from 211 European case-parent trios with and identified 13,522
Genome-wide association studies (GWAS) have generated unprecedented insights into the genetic etiology of orofacial clefting (OFC). The moderate effect sizes associated noncoding risk variants and limited access to disease-relevant tissue represent considerable challenges for biological interpretation findings. As rare with stronger are likely also contribute OFC, an alternative approach delineate pathogenic mechanisms is identify private mutations and/or increased burden in regions. This...
Comparative investigation concerning gelfiltration as well haemostaseologic analysis of venoms and venom fractions some snakes (elapidae viperidae) have shown that in elapidae an inhibition coagulation is dominant whilst viperidae the stimulation importance. Our investigations produce a basis to select substances for activation coagulation. Under pharmacological viewpoints data may information use snake anticoagulation or procoagulant therapy bleeding tendency.
Das PIE stellt eine seltene aber sehr ernste Komplikation des Atemnotsyndroms Neugeborener dar und ist Folge der besonderen strukturellen Beschaffenheit unreifen Lunge. Der vermehrte Bindegewebeanteil in Frühgeborenenlunge begünstigt die peribronchiale perivaskuläre Dissektion von Luft, durch Baro- Volutrauma damit verbundene Mikrorupturen Bronchial- Alveolarepithelien zustande kommt.
Das Auftreten einer Pfortaderthrombose (PVT) bei Leberzirrhose ist eine kontrovers diskutierte Komplikation. Die Auswirkungen auf den Verlauf der Erkrankung und mögliche negativ-prognostische Faktoren sind nicht abschließend geklärt.
Non-syndromic cleft lip with/without palate (nsCL/P) is a frequent congenital malformation with multifactorial etiology. While recent genome-wide association studies (GWAS) have identified several nsCL/P risk loci, the functional effects of associated non-coding variants are largely unknown. Furthermore, additional loci remain undetected due to lack power. As genetic might alter binding transcription factors (TF), we here hypothesized that integration data from TF sites, expression analyses...