A5042753300- Cellular Mechanics and Interactions
- Hedgehog Signaling Pathway Studies
- Cancer-related Molecular Pathways
- Assisted Reproductive Technology and Twin Pregnancy
- Planarian Biology and Electrostimulation
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Pregnancy and preeclampsia studies
- Heat Transfer and Boiling Studies
- Refrigeration and Air Conditioning Technologies
- Plant and Biological Electrophysiology Studies
- Heat Transfer and Optimization
- Reconstructive Surgery and Microvascular Techniques
- Peptidase Inhibition and Analysis
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Ectopic Pregnancy Diagnosis and Management
- Congenital Anomalies and Fetal Surgery
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Trace Elements in Health
- Congenital Diaphragmatic Hernia Studies
- Marine Invertebrate Physiology and Ecology
University College London
2021-2023
University College London Hospitals NHS Foundation Trust
2023
University of North Carolina at Chapel Hill
2015-2022
UNC Lineberger Comprehensive Cancer Center
2015-2022
University of Michigan–Ann Arbor
1983-2022
Genesys (United States)
2022
West Health
2022
University College Hospital
2021
Research Triangle Park Foundation
2020
East Bay Community Recovery Project
2018
Zn 2+ is required for many aspects of neuronal structure and function. However, the regulation in nervous system remains poorly understood. Systematic analysis tissue-profiling microarray data showed that zinc transporter ZIP12 ( slc39a12 ) highly expressed human brain. In work reported here, we confirmed a uptake with conserved pattern high expression mouse Xenopus system. Mouse neurons Neuro-2a cells produce fewer shorter neurites after knockdown without affecting cell viability. chelation...
The nucleus has long been postulated to play a critical physical role during cell polarization and migration, but that not defined or rigorously tested. Here, we enucleated cells test the necessity of directed migration. Using mammalian (cytoplasts), found polarity establishment migration in one dimension (1D) two dimensions (2D) occur without nucleus. Cytoplasts directionally migrate toward soluble (chemotaxis) surface-bound (haptotaxis) extracellular cues collectively scratch-wound assays....
β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis, and a vast array of human diseases. Signal propagation through WNT-Frizzled/LRP receptor complex requires proteins necessary for clathrin-mediated endocytosis (CME). Paradoxically, CME also negatively regulates signaling internalization degradation the complex. Here, using gain-of-function screen kinome, we report that AP2 associated kinase 1 (AAK1), known enhancer, inhibits signaling. Reciprocally, AAK1...
A common type of lymphoma overexpressing the transcription factor FOXP1 could be treated with Wnt/β-catenin inhibitors.
The basal-like breast cancer (BLBC) subtype accounts for a disproportionately high percentage of overall mortality. current therapeutic options BLBC need improvement; hence, elucidating signaling pathways that drive growth may identify novel targets the development effective therapies. Rho GTPases have previously been implicated in promoting tumor cell proliferation and metastasis. These proteins are inactivated by Rho-selective GTPase-activating (RhoGAP), which generally presumed to act as...
Abstract The incidence of cysts in pregnancy was established with ultrasound. In 3,330 pregnant patients who underwent sonography, 38 adnexal cystic lesions (1.14%) were found. All but two discovered before 16 weeks. Follow‐up showed that the majority resolved spontaneously; these presumed to represent corpus luteum cysts. Five surgery because persistent lesions; a mucinous cystadenoma, benign teratoma, paraovarian cyst, an inclusion and tuboovarian abscess Septations echogenic material seen...
The clinical course of 10 liver transplant recipients who had hepatitis B virus (HBV) and five with HBV D (delta) infection before transplantation is described. Six patients underwent eight transplants died. estimated one two year survival rates in only were 74% 67% respectively. HDV beforehand was 100%. Graft by occurred 8 infected only; 4 5 previous infection. There a widely variable time from to the appearance markers or serum, ranging 6-331 days. Hepatitis antigen (HDAg) appeared three...
Abstract A series of experiments to determine void fraction in both condensation and evaporation have been performed horizontal microfin tubes with refrigerants R134a R410A. Mass flux varied from 75 kg/m2·s 700 average test section quality 5% 80%. Zero degree (axial grooving) 18 helix tube configurations examined evaporation. Four were (7.3 mm 8.9 diameters axial angle microfins). Evaporation adiabatic conditions generally show similar trends found smooth tubes. Condensation results for a lower than
Ca2+ has long been known to play an important role in cellular polarity and guidance. We studied the of signaling during random directed cell migration better understand whether directs motility from leading edge which ion channels are involved this function using primary zebrafish keratinocytes. Rapid linescan time lapse imaging Ca2+i automated image alignment enabled us characterize map spatiotemporal changes Ca2+i. show that asymmetric distributions lamellipodial sparks encoded frequency,...
Actin filament dynamics must be precisely controlled in cells to execute behaviors such as vesicular trafficking, cytokinesis, and migration. Coronins are conserved actin-binding proteins that regulate several actin-dependent subcellular processes. Here, we describe a new conditional knockout cell line for two ubiquitous coronins, Coro1B Coro1C. These which strongly co-localize with Arp2/3-branched actin, require Arp2/3 activity proper localization. Coronin null have altered lamellipodial...
Abstract Emergency Medicine (EM) physicians frequently see patients with alcohol abuse or dependence (AA/AD). Brief interventions delivered in the Department (ED) have been advocated for these patients, however, little is known regarding EM physician willingness to support such interventions. We conducted a study determine physicians' attitudes toward use of AA/AD ED. All members Michigan College Physicians (n = 569) were mailed survey assess their intervention Of 257 respondents (45.9%),...
Junctional adhesion molecule-A (JAM-A) is an adherens and tight junction protein expressed by endothelial epithelial cells. JAM-A serves many roles contributes to barrier function cell migration motility, it also acts as a ligand for the leukocyte receptor LFA-1. reported contain N-glycans, but extent of this modification its contribution protein's functions are unknown. We show that human contains single N-glycan at N185 residue conserved across multiple mammalian species. A glycomutant...
ABSTRACT We describe a U.S. Army Ranger returning from duty in Afghanistan and Iraq with life-threatening infection due to Plasmodium vivax . Morphological variants were observed blood films prepared using samples collected by venipuncture. The patient's multiple relapses indicate primaquine-tolerant P. Strategies for relapse prevention primaquine are reviewed.
The ability to isolate and accurately position single cells in three dimensions is becoming increasingly important many areas of biological research. authors describe the design, theoretical modelling testing a novel dielectrophoretic (DEP) tweezer for picking out relocating target cells. device constructed using facilities available most electrophysiology laboratories, without requirement sophisticated expensive microfabrication technology, offers improved practical features over previously...
The human SOX9 gene, located in chromosome region 17q24.1-25.1, encodes a transcription factor involved chondrogenesis and testis development. Mutations this gene cause campomelic syndrome (CMPS) with autosomal sex reversal. Here we describe an infant girl CMPS interstitial deletion on the long arm of 17 (46,X,del(17)(q23.3q24.3). extent one was defined using unique sequence fluorescent situ hybridization probes. This is first report patient bearing complete as such strongest evidence to...