A5003655871- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Magnetism in coordination complexes
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Electron Spin Resonance Studies
- Radioactive element chemistry and processing
- Iron oxide chemistry and applications
- Characterization and Applications of Magnetic Nanoparticles
- Innovative Microfluidic and Catalytic Techniques Innovation
- Medical Imaging and Pathology Studies
- Hemoglobin structure and function
- Nuclear Materials and Properties
- Nanoplatforms for cancer theranostics
- Radical Photochemical Reactions
- Peptidase Inhibition and Analysis
- Advanced NMR Techniques and Applications
- Photodynamic Therapy Research Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound and Hyperthermia Applications
- Parathyroid Disorders and Treatments
- Phagocytosis and Immune Regulation
Conservatoire National des Arts et Métiers
2014-2025
Génomique Bioinformatique et Applications
2019-2024
Institut für Radiobiologie der Bundeswehr
2024
HESAM Université
2019-2023
Université Paris-Panthéon-Assas
2023
Laboratoire de Chimie Moléculaire
2018-2020
Laboratoire de Chimie
2016
Guerbet (France)
2005-2014
Prince of Wales Hospital
2013
Chinese University of Hong Kong
2013
The solution structure and dynamics of metal-bound water exchange have been studied in a series diastereoisomeric gadolinium complexes tetra(carboxyethyl) derivatives 1,4,7,10-tetraazacyclodecane. structures the (RRRS), (RSRS), (RRSS) ligands Eu, Gd, Tb (RRRR) isomer determined by X-ray crystallography. Luminescence measurements on Eu revealed an integral hydration state (q = 1) each case for isomers, whereas nonintegral values were measured (RRRS) isomers (e.g., [(RRRR)-Tb·1]-, q 0.60)....
Delivery of therapeutic or diagnostic agents to the brain is majorly hindered by blood-brain barrier (BBB). Recently, many studies have demonstrated local and transient disruption BBB using low power ultrasound sonication combined with intravascular microbubbles. However, opening closure mechanisms are poorly understood, especially maximum gap that may be safely generated between endothelial cells duration BBB. Here, we studied under magnetic resonance (MR) guidance in a rat model. First, MR...
In recent years there has been a renewed interest in the physicochemical properties of gadolinium chelates (GC). The aim this review is to discuss marketed GC with regard possible biological consequences. can be classified according three key molecular features: 1) nature chelating moiety: either macrocyclic molecules which Gd(3+) caged preorganized cavity ligand, or linear, open-chain molecules; 2) ionicity: ionicity molecule varies from neutral tri-anionic agents; and 3) presence absence...
Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTA⊂NPs) exhibited high relaxivity (r1=101.7 s−1 mM−1 per Gd3+ ion at 37 °C and 20 MHz). This relaxation rate is due to efficient Gd loading, reduced tumbling of the complex, hydrogel nature nanoparticles. The efficacy as a T1/T2 dual-mode contrast agent was studied in C6 cells (see picture). Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed,...
Objective— Despite great advances in our knowledge, atherosclerosis continues to kill more people than any other disease the Western world. This is because means of identifying truly vulnerable patients limited. Prediction atherosclerotic plaque rupture may be addressed by MRI activated matrix metalloproteinases (MMPs), a family enzymes that have been implicated vulnerability plaques prone rupture. study evaluated ability novel gadolinium-based contrast agent P947 target MMPs plaques....
Colloidal dispersions of monodispersed and high-crystalline magnetite nanoparticles have been used to establish a relationship between magnetic properties resonance (MR) relaxometric parameters in vitro. Magnetite with diameters 4 14 nm were synthesized by thermal decomposition Fe(acac)3 different organic solvents transformed hydrophilic changing oleic acid for dimercaptosuccinic (DMSA). A final treatment alkaline water was critical make the suspension stable at pH 7 xi-potential values -45...
Abstract Objectives We aimed to evaluate gadopiclenol, a newly developed extracellular nonspecific macrocyclic gadolinium-based contrast agent (GBCA) having high relaxivity properties, which was designed increase lesion detection and characterization by magnetic resonance imaging. Methods described the molecular structure of gadopiclenol measured r 1 2 properties at fields 0.47 1.41 T in water human serum. Nuclear relaxation dispersion profile measurements were performed from 0.24 mT 7 T....
Complexation of the lanthanides Eu3+, Gd3+, and Tb3+ with 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (dota) has been studied in solution by using potentiometry, luminescence spectrometry, EXAFS. Three series successive complexes were characterized at least two these methods: immediate [LnHn(dota)](n-1)+** intermediate [LnHn(dota)](n-1)+* 0 </= n 2, final [Ln(dota)]- complexes. The formation constants determined potentiometry. From results, a complexation mechanism...
A considerable increase in the saturation magnetization, M(s) (40%), and initial susceptibility of ultrasmall (<5 nm) iron oxide nanoparticles prepared by laser pyrolysis was obtained through an optimized acid treatment. Moreover, a significant enhancement colloidal properties, such as smaller aggregate sizes aqueous media increased surface charge densities, found after this chemical protocol. The results are consistent with reduction nanoparticle disorder induced...
Acute ischemic events are often caused by the disruption of lipid-rich plaques, which frequently not angiographically visible. Vascular cell adhesion molecule-1 and apoptotic cell-targeted peptides studied during our previous work were conjugated to ultrasmall superparamagnetic iron oxide (USPIO) (USPIO-R832 for vascular targeting; USPIO-R826 apoptosis targeting) assessed magnetic resonance imaging.Apolipoprotein E knockout mice injected with 0.1 mmol Fe/kg body weight imaged on a 4.7-T...
Molecular and cellular imaging of atherosclerosis has garnered more interest at the beginning 21st century, with aims to image in vivo biological properties plaque lesions. Apoptosis seems an attractive target for diagnosis vulnerable atherosclerotic plaques prone a thrombotic event. The aim present work was screen apoptosis peptide binders by phage display final purpose detect apoptotic cells magnetic resonance (MRI). A phosphatidylserine-specific identified thus used design MRI contrast...
The immobilization of soluble photocatalysts, or photosensitizers, has the potential to reduce environmental footprint as well costs associated with visible-light photochemical processes. We report here on straightforward preparation photocatalysts non-covalently supported silica using electrostatic interactions and compare activities these new photocatalytic systems in photo-oxidation 1,5-dihydroxynaphthalene juglone batch a fixed-bed flow reactor. This study demonstrates that simple...
Investigation of dissociated versus chelated gadolinium (Gd) in plasma, skin, and bone rats with impaired renal function after administration ionic macrocyclic (gadoterate or Dotarem) nonionic linear (gadodiamide Omniscan) Gd chelates.Subtotally nephrectomized Wistar were subjected to receive daily injections 2.5 mmol/kg Omniscan, gadodiamide without excess ligand caldiamide, Dotarem, saline (n = 7-10 rats/group) for 5 consecutive days. The concentration was measured by inductively coupled...