A5010579458- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Catalytic Reactions
- Asymmetric Hydrogenation and Catalysis
- Catalytic Alkyne Reactions
- Alkaloids: synthesis and pharmacology
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive Natural Diterpenoids Research
- Organophosphorus compounds synthesis
- Metal-Organic Frameworks: Synthesis and Applications
- Organoboron and organosilicon chemistry
- Covalent Organic Framework Applications
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Coordination Chemistry and Organometallics
- Chemical Synthesis and Reactions
- Lipid Membrane Structure and Behavior
- Allelopathy and phytotoxic interactions
- Marine Sponges and Natural Products
- Plant-derived Lignans Synthesis and Bioactivity
Shanghai University of Traditional Chinese Medicine
2019-2024
Zhengzhou University
2024
Shanghai Institute of Organic Chemistry
2013-2016
Jilin University
2011-2012
University of Waterloo
1989
Antivirulence therapy by cell membrane coated nanoparticles has shown promise against bacterial infections. However, current approaches remain unsatisfactory when facing Escherichia coli (E. coli) infections, since the E. secretes multiple toxins including endotoxins and exotoxins that are challenging to eliminate simultaneously. What is worse, absorptive scavengers normally rely on random contact of diffuse toxins, which not efficient. For platform, single type cannot fully meet detoxing...
Huperzine A, huperzine B, and U are congeners isolated from the Chinese herb Huperzia serrata (=Lycopodium serratum) in minuscule amounts. The most efficient total synthesis of first asymmetric syntheses have been achieved efficiently overall yields 17%, 10%, 9%, respectively, each spanning 10–13 steps (R)-pulegone. featured include palladium-catalyzed Buchwald–Hartwig coupling Heck cyclization reactions an Ir-catalyzed olefin isomerization reaction. This work has established absolute...
Abstract Alkynylation of alkenyl bromoarenes via aryl to vinyl 1,4‐palladium migration/copper‐free Sonogashira coupling sequence has been developed. This approach provides a facile methodology for the highly stereoselective synthesis multi‐substituted 1,3‐enynes in good excellent yields and regioselectivities.
1,4-Palladium migration has emerged as a reliable method for directed C–H functionalization. In contrast to coupling with carbon nucleophiles, limited examples heteroatom nucleophiles have been reported. Herein we report palladium-catalyzed intermolecular C(sp3)–H phosphorylation reaction via 1,4-palladium migration, which is often difficult because of the strong coordination phosphorus reagents palladium catalysts. Phosphorylation bonds accomplished in good yields excellent...
The first tertiary amine-catalyzed tandem cyanation–allyic alkylation (CAA) reaction of aldehydes, appropriate cyanide sources, and Morita–Baylis–Hillman (MBH) adducts has been developed, which provides a facile access to densely functionalized products containing O-substituted quaternary centers.
The synthesis of vinyl sulfones <italic>via</italic> silver-promoted cross-coupling bromides with sulfonyl hydrazides was realized.
Regiospecific efficient syntheses of 1-, 2-, 3-, and 4-nitrofluorenones 8 the corresponding nitrofluorenes 10 by palladium(0)-catalyzed cross-coupling reactions aryl boronic acids 1 with bromonitrotoluenes 2 bromonitrobenzene 3 are described.
A palladium-catalyzed intermolecular cross-coupling of unreactive C(sp3)-H bonds and azole C(sp2)-H with bromide as a traceless directing group is described. The judicious selection the bulky electron-rich phosphine ligand key for success this cascade process. protocol features broad substrate scope, excellent regioselectivity, good functional tolerance.
Comprehensive Summary Vinylphosphates play an important role in the fields of synthetic chemistry, pharmaceuticals and material science. It is a long‐standing challenge to control geometry multi‐substituted vinylphosphates. Herein, efficient method for synthesis 2,2‐disubstituted vinylphosphonates has been reported. The reaction proceeded via aryl vinyl 1,4‐palladium migration progress, which two difficulties that deactivation palladium catalyst by coordination excess secondary phosphine...
We report herein the asymmetric total synthesis of α-obscurine (<bold>1</bold>), β-obscurine (<bold>2</bold>), <italic>N</italic>-desmethyl-α-obscurine (<bold>3</bold>), and <italic>N</italic>-desmethyl-β-obscurine (<bold>4</bold>).
A palladium-catalyzed disilylation reaction applicable for a variety of non-, α-, or β-substituted and α,β-disubstituted ortho-halophenylethylenes has been developed. This proceeds with high yields very low catalyst loadings. The two C-Si bonds the disilylated products could be well-differentiated chemoselectively in various electrophiles.
An organocatalytic formal [4 + 2] cycloaddition reaction has been realized that permits rapid access to a wide range of bicyclo[2.2.1]heptane-1-carboxylates in highly enantioselective manner from simple starting materials under mild and operationally conditions.
Abstract A cascade [4+3] annulation of o ‐alkenyl bromoarenes and ‐bromoaniline derivatives was described. Various dibenzo[ b , f ]azepines with substitutions on the 10/11 position were obtained in 14–97% yields. The synthetic versatility this protocol is highlighted by preparation a precursor drug molecule oxcarbazepine, gram‐scale synthesis, two product transformations. Unlike previous amination/Heck sequence, process supposed to undergo C(vinyl), C(aryl)‐palladacycle involved pathway.
A family of 9-azabicyclo[3.3.1]nonadiene ligands were developed, and the nitrogen atom in bridged ring enables a facile immobilization diene to silica.
Covalent organic frameworks (COFs) are a new class of crystalline porous polymers that have sparked widespread interest due to their diverse topologies and prospective applications in heterogeneous catalysis, sewage treatment, fluorescence sensing, proton conduction, other domains. In this context, imine-connected COFs currently being synthesized mostly using classic solvothermal techniques, which is incompatible with the concept green chemistry need for high reaction temperatures (120–180...
Abstract Palladium-catalyzed cross-coupling of ortho-alkenyl bromobenzenes and α-aryl-α-diazoesters was realized. The reactions proceeded in moderate to excellent yields with broad substrate scope, providing a straightforward method for the synthesis 1,1-disubstituted indenes. reaction is thought undergo tandem alkenyl C–H activation/carbene insertion sequence, which C,C-pallada(II)cycle key intermediate.
Abstract An intramolecular palladium‐catalyzed tandem γ‐arylation/aromatization reaction of cyclohex‐2‐en‐1‐one derivatives was developed. This work provides a simple and efficient approach for the construction substituted 3,4‐dihydroanthracen‐1(2 H )‐ones in good yields with broad substrate scope. magnified image
Abstract The DABCO‐catalyzed allylic alkylation of Morita—Baylis—Hillman adducts (II) with preformed cyanohydrins (I) leads to highly functionalized products (III), which can be readily converted into ketone (VI) or oxazolidinone (VIII).
Total synthesis of (−)-amathaspiramide A was achieved through efficient construction a chiral aza-spirobicyclic core using an aldol addition/transamidification cascade. Configuration adjustment via asymmetric protonation process used to obtain the stereochemistry.