A5079169653- Nanoplatforms for cancer theranostics
- Nutrition and Health in Aging
- Ion channel regulation and function
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Frailty in Older Adults
- Acupuncture Treatment Research Studies
- Nicotinic Acetylcholine Receptors Study
- Gout, Hyperuricemia, Uric Acid
- Body Composition Measurement Techniques
- Extracellular vesicles in disease
- Hemoglobin structure and function
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Enhanced Oil Recovery Techniques
- Lipid Membrane Structure and Behavior
- Systemic Lupus Erythematosus Research
- Venomous Animal Envenomation and Studies
- Diet, Metabolism, and Disease
- Vitamin D Research Studies
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Mass Spectrometry Techniques and Applications
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
Zhejiang University-University of Edinburgh Institute
2025
University of Washington
2019-2024
Harbin Institute of Technology
2022-2024
Weihai Science and Technology Bureau
2023-2024
Tencent (China)
2024
First Hospital of Jilin University
2022-2023
Jilin University
2022-2023
Southwest Minzu University
2022
Heilongjiang University of Chinese Medicine
2022
Fudan University
2015-2022
The targeted delivery of therapeutics to sites rheumatoid arthritis (RA) has been a long-standing challenge. Inspired by the intrinsic inflammation-targeting capacity macrophages, macrophage-derived microvesicle (MMV)-coated nanoparticle (MNP) was developed for targeting RA. MMV efficiently produced through novel method. Cytochalasin B (CB) applied relax interaction between cytoskeleton and membrane thus stimulating secretion. proteomic profile analyzed iTRAQ (isobaric tags relative absolute...
Superhydrophilic zwitterionic polymers derived from trimethylamine N -oxide are reported as a new class of nonfouling materials.
Although several strategies have been applied for oral insulin delivery to improve bioavailability, little success has achieved. To overcome multiple barriers absorption simultaneously, insulin-loaded N-trimethyl chitosan chloride (TMC)-coated polylactide-co-glycoside (PLGA) nanoparticles (Ins TMC-PLGA NPs) were formulated in our study. The Ins NPs prepared using the double-emulsion solvent evaporation method and characterized determine their size (247.6 ± 7.2 nm), ζ-potential (45.2 4.6 mV),...
Rheumatoid arthritis (RA) is a chronic, systemic, progressive autoimmune disease. The vascular permeability of inflamed joints in RA makes it natural candidate for passive targeting, similar to the enhanced and retention (EPR) effect solid tumors. Thus, various therapeutic drugs have been encapsulated nanocarriers achieve longer vivo circulation times improve targeting. Although liposomes are most widely used treatment, effects physical chemical characteristics liposomes, such as particle...
An innovative biomimetic polymer integrates zwitterionic non-fouling properties with immunomodulatory functionality.
Pore-forming toxins (PFTs) are the most common bacterial virulence proteins and play a significant role in pathogenesis of infections; thus, PFTs an attractive therapeutic target infections. Inspired by pore-forming process mechanism PFTs, we designed integrated hybrid nanovesicle—the erythroliposome (called RM-PL)—for PFT detoxification fusing natural red blood cell (RBC) membranes with artificial lipid membranes. The RBC were mutually beneficial when into nanovesicle structure. membrane...
Abstract Inspired by the amino acid composition of natural protein surfaces, we developed a zwitterionic cloak containing multi‐layers short alternating glutamic and lysine (EK) peptides as facile, highly effective low‐immunogenicity approach for protection delivery biotherapeutics. Each EK layer grafted to proteins provides multiple times new reaction sites growth subsequent layers. This unique design allows achieve high coating density on proteins, overcoming limitation traditional...
Antivirulence therapy by cell membrane coated nanoparticles has shown promise against bacterial infections. However, current approaches remain unsatisfactory when facing Escherichia coli (E. coli) infections, since the E. secretes multiple toxins including endotoxins and exotoxins that are challenging to eliminate simultaneously. What is worse, absorptive scavengers normally rely on random contact of diffuse toxins, which not efficient. For platform, single type cannot fully meet detoxing...
Abstract Due to the presence of blood–brain barrier (BBB), delivery general drugs into brain tissue remains be a tricky problem. For patients with metastases from breast cancer, drug systems must overcome this physical barrier. Targeted nano vehicles arise as promising alternative deliver tissues successively. Herein, dual targeting micelle system loaded paclitaxel (PTX) and lapatinib (LPTN) was developed for combinational therapy metastases. In our study, it shown micelles modified...
The outcome of scaffold-based stem cell transplantation remains unsatisfied due to the poor survival transplanted cells. One major hurdles associated with is immune rejection, which can be effectively reduced by use immunosuppressant. However, ideal localized and sustained release immunosuppressant difficult realized, because it arduous hold drug delivery system within scaffold for a long period time. In present study, purpose improving cells was successfully realized nanoparticle-anchoring...
Background and aims As a chronic wasting disease, cancer can lead to metabolic physiological changes in patients, resulting severe malnutrition. Therefore, accurate assessment of nutritional status adoption scientifically sound interventions are great importance for patients with cancer. This study aimed assess the necessity implementing Nutrition Risk Screening 2002 (NRS 2002) tool conjunction Patient-Generated Subjective Global Assessment (PG-SGA) Methods retrospective collected clinical...
The lymphatic system provides a major route for the dissemination of many diseases such as tumor metastasis and virus infection. At present, treating these remains knotty task due to difficulty delivering sufficient drugs into lymphatics. After subcutaneous (SC) injection, transferring vessels is significantly attenuated by physiological barriers in interstitial space. Moreover, SC injection represents highly challenging administration biological drugs, it increases risk undesirable immune...
The cytomembrane-derived delivery platform represents a promising biomimetic strategy in oncotherapy. To achieve durable and reliable tumor inhibition, mature dendrosomes (mDs), which were isolated from bone marrow-derived dendritic cells undergoing CT26 antigen (TA) stimulation, fused with redox-responsive nanoparticles (NPs) that composed of poly(disulfide ester amide) polymers an intensified disulfide density hydrophobic oxaliplatin (OXA) prodrugs the ability to potentiate immunogenicity.
ABSTRACT One kind of polymer gel P(AM‐AA‐AMPS) was prepared by radical aqueous copolymerization, using acrylamide (AM), acrylic acid (AA) and 1‐acrylanmido‐2‐methylpropanesulfonic (AMPS) as monomers, N,N‐methacrylamide (MBA) crosslinker ammonium persulfate (APS) initiator. The microstructure molecular structure the were characterized environmental scanning electron microscope (ESEM), infrared spectrometer (IR) thermal gravity analysis (TGA). Main factors affecting gelation behavior...
Feline calicivirus (FCV) is a well-known causative pathogen for upper respiratory infection in cats. Its high genetic variability challenges existing molecular diagnostic methods clinical settings. Thus, we developed two sensitive and visual assays FCV nucleic acid detection based on RPA reaction CRISPR-Cas13a trans-cleavage activity. Recombinant plasmid DNA, crRNAs, primers were designed prepared, respectively, targeting to ORF1 gene. Besides, purified LwCas13a protein was produced by...
Reduced muscle mass (RMM) is a phenotypic criterion for malnutrition; the appendicular skeletal index (ASMI) and fat-free (FFMI) are both applicable indicators in global leadership initiative on malnutrition (GLIM) guideline. However, their sensitivity prognostic effect remain unclear.Clinical data of 2,477 patients with malignant tumors were collected. Multi-frequency bioelectrical impedance analysis was used to obtain ASMI FFMI. RMM confirmed by (< 7.0 kg/m2 men < 5.7 women) or FFMI 17 15...