A5040782517- Immune Cell Function and Interaction
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Malaria Research and Control
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Celiac Disease Research and Management
- Hepatitis B Virus Studies
- Phagocytosis and Immune Regulation
- Hepatitis C virus research
- Tryptophan and brain disorders
- Mosquito-borne diseases and control
- Inflammasome and immune disorders
- Parasites and Host Interactions
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Advancements in Transdermal Drug Delivery
- Microscopic Colitis
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- Parasite Biology and Host Interactions
- Burkholderia infections and melioidosis
- RNA Interference and Gene Delivery
Golestan University of Medical Sciences
2015-2024
Golestan University
2015-2024
University of Nizwa
2024
High Institute for Education and Research in Transfusion Medicine
2022
Delhi Technological University
2022
Tehran University of Medical Sciences
2022
Islamic Azad University Bandar Abbas
2022
University of Pretoria
2021
Shiraz University
2020
Payame Noor University
2017
Macrophages are versatile phagocytic cells in immune system with immunoregulatory functions. However, the removal of apoptotic by macrophages is disturbed systemic lupus erythematosus (SLE). Aryl hydrocarbon receptor (AhR) a ligand-activated cytoplasmic and transcription factor diverse effects on response. Indole-3-carbinol (I3C) an AhR agonist which has been implicated as beneficial regulating inflammation cytokine expression murine models SLE. molecular mechanisms not thoroughly studied....
Macrophages have recently gained attention in systemic lupus erythematosus (SLE) pathogenesis for their role the anti-inflammatory clearance of apoptotic cells. The M1/M2 polarization macrophages improves efferocytic capability. Peroxisome proliferator-activated receptor γ is proposed to function expansion M2 subpopulation. Pioglitazone a peroxisome agonist with variety effects. In this paper, we investigated ex vivo alterations monocyte-derived 15 newly diagnosed SLE patients and 10 normal...
The role of aryl hydrocarbon receptor (AhR) in carcinogenesis has been studied recently. Indole-3-carbinol (I3C) is an AhR agonist and a potential anticancer agent. Here, we investigated the effects I3C on cell cycle progression apoptosis through activation THP-1 acute myeloid leukemia (AML) line.MTT viability assay was used to measure cytotoxic cells. Apoptosis assays were using flow cytometry. Real time RT-PCR conducted alterations expression gene, key genes associated with (IL1β CYP1A1)...
Background: Fresh vegetables are an important part of a healthy diet. In recent years there has been increase in the number reported cases food-borne illness regarding fresh vegetables. Objectives: The objective this study was to evaluate parasitological contamination which consumed raw and commercialized Zahedan, Iran. These findings could lead better practices handling protect against intestinal parasitic infections. Materials Methods: We studied 96 samples including Garden cress, Wild...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown aetiology. According to the role of interleukin 10 (IL10) in SLE pathogenesis, genetic alterations its promoter region could be associated elevated IL10 levels and exacerbated disease. Here, we investigated association genotype haplotype frequencies three gene polymorphisms susceptibility SLE, plasma activity patients an Iranian population. A total 116 131 healthy subjects were enrolled. The PCR-RFLP technique...
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Background: Candida albicans is the primary pathogen responsible for oral candidiasis. The emerging resistance of fungi to antifungal agents has led development new fungicidal treatments. Objectives: This study aimed analyze effects 660, 810, and 940 nm laser wavelengths on nystatin-resistant C. albicans. Methods: In this in vitro study, a standard strain eight isolates were irradiated with diode lasers 40 80 seconds (s) compared nystatin. Colony numbers nystatin susceptibility evaluated...
Current acute myeloid leukemia (AML) therapeutic strategies have irreversible side-effects. Berberine (BBR) is an isoquinoline alkaloid, which has been known as aryl hydrocarbon receptor (AhR) ligand. AhR a cytoplasmic receptor, involved in the regulation of cellular and immune responses. Here, we investigated expression profile genes cell cycle different cytokines upon BBR-mediated activation on AML THP-1 line.THP-1 cells normal monocytes were treated with concentrations BBR (10 μM, 25 50...
Periodontitis is an inflammatory disease that a result of the interaction between pathogenic bacteria and host immune response. Genetic alterations in interleukin-10 (IL-10) gene may be associated with increased risk periodontitis. We investigated association genotype haplotype frequencies IL-10 polymorphisms susceptibility to periodontitis Iranian population.In this case-control study, total 64 patients 128 healthy subjects were recruited. The PCR-RFLP technique was used detect promoter...
Celiac disease (CD) is a genetically determined autoimmune triggered by gluten consumption. Patients with these conditions have intraepithelial lymphocytosis, crypt hyperplasia, and severe intestinal atrophy. Gluten elimination the only way to reduce this chronic inflammation. The diagnosis of CD usually made analyzing anti-tTG, anti-DGP, or EMA serological tests, it confirmed biopsy duodenum. In people CD, xerostomia dry mouth common complication. This condition causes salivary glands...
Background Serotonin (5-HT) is a neurotransmitter with extensive physiological influence in the central nervous system (CNS) and various behavioral biological functions, including immune regulation through 5-HT receptors (5-HTRs) expressed by cells. A variety of serotonin-modulating drugs have been developed to treat neurological disorders. Phenelzine, drug indicated for management treatment-resistant depression, potent, non-selective inhibitor monoamine oxidase (MAO), enzyme that...
Abstract Background: Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan catabolizing enzyme which involved in immune regulation and autoimmune disorders such as systemic lupus erythematosus (SLE). Interferon-γ (IFN-γ) an inflammatory cytokine the major inducer of IDO expression. Here, we evaluated level IFN-γ among SLE patients correlation with severity SLE. Methods: Fifty-three 35 age matched healthy donors were enrolled this study. Systemic disease activity index (SLEDAI) was used to...