A5047969704- Hepatitis B Virus Studies
- Hepatitis C virus research
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Parvovirus B19 Infection Studies
- COVID-19 Clinical Research Studies
- Cervical Cancer and HPV Research
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Vector-Borne Animal Diseases
- interferon and immune responses
- Protein Structure and Dynamics
- Vibrio bacteria research studies
- RNA Interference and Gene Delivery
- Plant Virus Research Studies
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Signaling Pathways in Disease
- Toxin Mechanisms and Immunotoxins
- Herpesvirus Infections and Treatments
Iran University of Medical Sciences
2023-2025
Golestan University
2016-2025
Golestan University of Medical Sciences
2016-2025
Fasa University of Medical Sciences
2025
Ardabil University of Medical Sciences
2023-2024
Rasool Akram Hospital
2024
Tehran University of Medical Sciences
2021
Islamic Azad University of Gorgan
2020
Isfahan University of Medical Sciences
2018
Due to its global burden, Targeting Hepatitis B virus (HBV) infection in humans is crucial. Herbal medicine has long been significant, with flavonoids demonstrating promising results. Hence, the present study aimed establish a way of identifying anti-HBV activities. Flavonoid structures activities were retrieved. A flavonol-based pharmacophore model was established using LigandScout v4.4. Screening performed PharmIt server. QSAR equation developed and validated independent sets compounds....
Abstract Objectives Pseudomonas aeruginosa is known as a leading cause of nosocomial infections worldwide. Antimicrobial resistance and biofilm production, two main virulence factors P. , are responsible for the persistence prolonged infections. In this study, antimicrobial susceptibility pattern phenotypic genotypic characteristics were investigated. Results A total 80 clinical isolates obtained. Isolates showed to all antibiotics with rate from 12.5% (n = 10) against amikacin...
Flavonoids, a diverse group of polyphenolic compounds found in various plant-based foods, have garnered attention for their potential combating Hepatitis B Virus (HBV) infection. Flavonoids demonstrated promising anti-HBV activities by interfering with multiple stages the HBV life cycle, making them candidates novel antiviral agents. Certain plant families, such as Theaceae , Asteraceae Lamiaceae and Gentianaceae are particular interest flavonoid-rich members activities. Evidences, both...
Staphylococcus saprophyticus (S. saprophyticus) is the second most prevalent etiological agent of urinary tract infections (UTIs) in young women. However, there a paucity data regarding its bacteriophage (phage). Therefore, this study was conducted to isolate and identify new lytic phages from municipal wastewater with objective increasing knowledge about their genomes. A total 11 clinical isolates S. 30 samples were used three (vB_SsapH-Golestan-100, vB_SsapH-Golestan101-M,...
Background Human papillomavirus (HPV), with more than 200 types, is the primary etiological factor of cervical cancer. This study aimed to assess HPV genotypes 755 women in Fasa, Iran, determine prevalence and distribution different types their relationship lesions. Methods Cervical tissue samples were obtained from 2017 2022. Genomic DNA was extracted used for genotyping via real-time PCR method. A cytological examination also performed classify GraphPad/Prism8.0.2 software utilized...
The Hepatitis B virus (HBV) core protein is an attractive target for preventing capsid assembly and viral replication. Drug repurposing strategies have introduced several drugs targeting HBV protein. This study used a fragment-based drug discovery (FBDD) approach to reconstruct repurposed inhibitor some novel antiviral derivatives. Auto Core Fragment in silico Screening (ACFIS) server was deconstruction-reconstruction of Ciclopirox complex with derivatives were ranked based on their free...
Aim: COVID-19 is a global health threat. Therapeutics are urgently needed to cure patients severely infected with COVID-19. Objective: investigate potential candidates of nsp12 inhibitors by searching for druggable cavity pockets within the viral protein and drug discovery. Methods: A virtual screening ZINC natural products on SARS-CoV-2 nsp12's was performed. lead compound highest affinity simulated dynamically 10 ns. Results: ZINC03977803 nominated as compound. The results showed stable...
Aim: Virus spike glycoprotein of SARS-CoV-2 is a good target for drug discovery. Objective: To examine the potential druggability protein pharmacophore-based discovery and to investigate binding affinity natural products with protein. Methods: Druggable cavities were searched though CavityPlus. A pharmacophore was built used hit identification. Autodock Vina evaluate hits' affinities. 10 chemical derivatives also made from backbone optimize lead compound. Results: druggable found within...
Redondoviridae is a newly discovered virus family linked to oral and respiratory conditions in people, while there still debate about whether it also coinfected with other viruses. This study aimed determine the frequency of Redondovirus (ReDoV) nasopharyngeal samples investigate any possible links SARS-CoV-2 infections.
Diced cartilage grafts are well-liked, dependable, and simple-to-use techniques for dorsum camouflage in rhinoplasty. Recent research results demonstrate how effectively PRF increases the survivability of diced nasal decreases its absorption. In this study, we intend to investigate effect fibrin-rich platelets (PRF) on survival rhinoplasty surgery.
Background: Variations in the viral receptor human angiotensin-converting enzyme 2 (ACE2) may specify susceptibility of a certain population to severe acute respiratory syndrome coronavirus 2. Objective: Evaluation affinity spike glycoprotein Iranian genetic variants ACE2. Materials & methods: Single nucleotide polymorphisms ACE2 among were collected from Iranome database. Missense mutations N-terminal peptidase domain selected for silico analysis. Results: 17 missense single found at Viral...
<b><i>Background:</i></b> Many efforts are currently focused on functional treatment of the hepatitis B virus (HBV). This can be done by suppressing secretion HBV surface antigen (HBsAg). Scientific communities very interested in natural products that respect. <b><i>Objective:</i></b> Use root extract Havachoobe (<i>Onosma dichroanthum BoissI</i>), a Northern Iranian native medical herb, for assessment its anti-HBsAg activity....
COVID-19 pathogenesis is mainly attributed to dysregulated antiviral immune response, the prominent hallmark of COVID-19. As no established drugs are available against SARS-CoV-2 and developing new ones would be a big challenge, repurposing existing holds promise Here, we used signature-based strategy delve into cellular responses infection in order identify potential host contributors find repurposable using silico approaches. We scrutinized transcriptomic profile various human alveolar...
Aim: Human cytomegalovirus (HCMV) treatment is hard to achieve because of viral protein target sequence variations. Objectives: We aimed find HCMV pUL97 kinase variations in HIV- and congenitally infected patients. Methods: Twenty HCMV-positive DNA samples from nonganciclovir treated neonates HIV positive patients were used for PCR restriction fragment length polymorphism. Variations assessed computationally functionality. Results: P521L, D605E N597Y substitutions prevalent significantly...