A5070557401- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Sepsis Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Pancreatitis Pathology and Treatment
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Chronic Myeloid Leukemia Treatments
- Health Promotion and Cardiovascular Prevention
- Hematological disorders and diagnostics
- Thermal Regulation in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Neuroendocrine regulation and behavior
- Nosocomial Infections in ICU
- Inflammatory Myopathies and Dermatomyositis
- Chronic Lymphocytic Leukemia Research
- Acute Myocardial Infarction Research
- Infectious Diseases and Tuberculosis
- Global Public Health Policies and Epidemiology
Firoozgar General Hospital
2020-2025
Iran University of Medical Sciences
2020-2025
Shaheed Rajaei Cardiovascular Medical and Research Center
2022
Masih Daneshvari Hospital
2019
Shahid Beheshti University of Medical Sciences
2019
Urmia University of Medical Sciences
2014
Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.To evaluate effects intermediate-dose vs standard-dose prophylactic anticoagulation among COVID-19 admitted intensive care unit (ICU).Multicenter randomized trial a 2 × factorial design performed 10 academic centers Iran comparing (first hypothesis) and statin therapy matching placebo (second hypothesis; not this article) adult ICU Patients...
Microvascular and macrovascular thrombotic events are among the hallmarks of coronavirus disease 2019 (COVID-19). Furthermore, exuberant immune response is considered an important driver pulmonary extrapulmonary manifestations COVID-19. The optimal management strategy to prevent thrombosis in critically-ill patients with COVID-19 remains unknown.
Abstract Background Thrombotic complications are considered among the main extrapulmonary manifestations of coronavirus disease 2019 (COVID-19). The optimal type and duration prophylactic antithrombotic therapy in these patients remain unknown. Methods This article reports final (90-day) results Intermediate versus Standard-dose Prophylactic anticoagulation In cRitically-ill pATIents with COVID-19: An opeN label randomized controlled trial (INSPIRATION) study. Patients COVID-19 admitted to...
Abstract Objective To assess the effect of statin treatment versus placebo on clinical outcomes in patients with covid-19 admitted to intensive care unit (ICU). Design INSPIRATION/INSPIRATION-S was a multicenter, randomized controlled trial 2×2 factorial design. Results for anticoagulation randomization have been reported previously. double blind atorvastatin are here. Setting 11 hospitals Iran. Participants Adults aged ≥18 years ICU. Intervention Atorvastatin 20 mg orally once daily...
Research on low physical activity (LPA) in the Middle East and North Africa (MENA) region remains limited. To assess disease burden associated with LPA using data from Global Burden of Disease (GBD) study. Longitudinal epidemiological GBD 2021 were used to extract information eight LPA-related conditions-breast cancer, chronic kidney disease, colorectal diabetes mellitus (DM), ischemic heart lower extremity peripheral arterial stroke, tuberculosis-analyzed by age group, sex, country within...
Background Human papillomavirus (HPV), with more than 200 types, is the primary etiological factor of cervical cancer. This study aimed to assess HPV genotypes 755 women in Fasa, Iran, determine prevalence and distribution different types their relationship lesions. Methods Cervical tissue samples were obtained from 2017 2022. Genomic DNA was extracted used for genotyping via real-time PCR method. A cytological examination also performed classify GraphPad/Prism8.0.2 software utilized...
Background: Severe coronavirus disease 2019 (COVID-19) may lead to the cytokine storm syndrome which cause acute respiratory failure and death. Our aim was investigate therapeutic effects of infliximab, intravenous gammaglobulin (IVIg) or combination therapy in patients with severe COVID-19 admitted intensive care unit (ICU). Methods: In this observational research, we studied 104 intubated adult infection (based on clinical symptoms, radiographic CT scan parameters) who were ICU a...
Background In the INSPIRATION-S trial, atorvastatin versus placebo was associated with a nonsignificant 16% reduction in 30-day composite of venous/arterial thrombosis or death intensive care unit (ICU) patients COVID-19. Thrombo-inflammatory response coronavirus disease 2019 (COVID-19) may last beyond first 30 days. Methods This article reports effects 20 mg daily on 90-day clinical and functional outcomes from INSPIRATION-S, double-blind multicenter randomized trial adult ICU The main...
BACKGROUND: Fiberoptic bronchoscopy (FOB) guided bronchoalveolar lavage (BAL) remains as the chief diagnostic tool in respiratory disorders. 1.2-16% of patients frequently experience fever after bronchoscopy. To exclude need for multiple antibiotic prescribing with post-bronchoscopy fever, presence self-limiting inflammatory responses should be excluded.
 AIM: The current study was conducted to test serum undergoing some proinflammatory cytokines including Tumor Necrosis Factor-alpha...
Introduction Diabetes mellitus and hypertension are described as the most common comorbidities among COVID-19 patients. We investigated adverse effect of ACEIs in diabetic nondiabetic patients with COVID-19. Methods This prospective study consisted 617 RT-PCR-confirmed inpatients. Demographic baseline characteristics, underlying comorbid diseases, antihypertensive drugs were evaluated. Study outcome (in-hospital death) was evaluated Kaplan-Meyer method Cox regression model. Statistical...
BACKGROUND: Abdominal compartment syndrome patients suffer severe obstacles such as kidney failure and shock. To evade further complications, identifying the abdominal (ACS) Intra-abdominal hypertension (IAH), in critically ill individuals hospitalised intensive care unit (ICU) is obligated.
 AIM: The current study intended to concomitant risk factors among ICU, by using pressure test.
 MATERIAL AND METHODS: One hundred twenty-five at ICU entered survey. was measured standard...
Considering the high prevalence of vitamin D deficiency worldwide and its relationship with immune response to viral infections, this study attempted identify predictive power serum for poor outcomes among COVID-19 patients. This retrospective cohort included all patients confirmed hospitalized between February 20, 2020, April at a designated hospital, located in Tehran province, Iran. General characteristics, medical history clinical symptoms were recorded by trained physicians. Blood...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [COVID-19] quickly turned into a pandemic. Gastrointestinal involvement, especially liver diseases, is one of the main complications COVID-19 patients. Objectives: The current study aimed to evaluate high incidence involvement in hospitalized patients and its association with mortality. Methods: A total 560 confirmed diagnosis were included. Death was considered as outcome. In addition enzymes, demographic, clinical,...
We assessed the association between severity of COVID-19 and thyroid function, relationship hormones with inflammatory markers in patients.This observational study contained 95 patients. The covariates interest included thyroid-stimulating hormone (TSH) total form thyroxine triiodothyronine. Furthermore, including C-reactive protein, erythrocyte sedimentation rate, lactate dehydrogenase (LDH), lymphocyte were measured. To analyze data, t-test, nonparametric test for comparing medians,...
Abstract Background : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection and treatment are significant health organizations' concerns worldwide. Although there is no proven drug license against the virus, a variety of components have under investigation. In this regard, present study was intended to evaluate consequences Sovodak (Sofosbuvir/Daclatasvir) in COVID-19 patients compared with Kaletra (Lopinavir/ritonavir). Methods This conducted as randomized trial using 120...
Due to widespread of coronavirus disease 2019 (COVID-19) infection, identification its risk factors and clinical characteristics are important. The aim the present study was assess Vitamin D levels in individuals with severe acute respiratory syndrome coronavirus-19 infection report on potential as a predictive marker.
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection and treatment are significant health organizations’ concerns worldwide. Although there is no proven drug license against the virus, a variety of components have under investigation. Objectives: In this regard, present study was intended to evaluate consequences Sovodak (sofosbuvir/ daclatasvir) in COVID-19 patients compared with Kaletra (lopinavir/ritonavir). Patients Methods: This conducted as randomized...
Although the role of oxytocin in pathophysiology sepsis is still unknown, rising preclinical evidence suggests that possibly involved. However, no direct clinical studies have measured levels during sepsis. In this preliminary study, serum were evaluated throughout duration sepsis.Twenty-two male patients over 18 years age with a SOFA score 2 points or more who admitted to ICU included. Patients history neuroendocrine, psychiatric, and neurologic disorders, cancer, an infection caused by...
Background: To date, no specific medication has been shown to be effective in treating COVID-19. Objectives: Due the role of medicinal plants reducing symptoms viral diseases, present study aimed assess efficacy an herbal medicine package (anti-flu Pulmo-Health), prepared based on Persian traditional instructions and bioinformatics studies, COVID-19 outpatients. Methods: This double-blinded randomized controlled trial was conducted 60 outpatients referred Emergency Department Baqiyatallah...
Background: Anti-inflammatory agents have been proposed to improve oxygenation and mortality rates in severe COVID-19 pneumonia. This study has assessed the impact of colchicine as a coadjuvant inflammatory agent infliximab adults hospitalized with Method: In this randomized, open-label clinical trial, 63 pneumonia patients according criteria National Institutes Health, 18 85 years old, an increase TNF-α IL-6 levels, were randomized receive 1 mg for 7 days single dose 300 on first day...
Background: In the Intermediate vs Standard-Dose Prophylactic Anticoagulation in Critically-ill Patients With COVID-19: An Open Label Randomized Controlled Trial (INSPIRATION) trial, intermediate- compared with standard-dose prophylactic anticoagulation did not reduce a composite of venous/arterial thrombosis, treatment extracorporeal membrane oxygenation or mortality. Whether machine learning (ML) implemented to predict individualized effects (ITE) would identify variations outcomes using...
Backgrounds: In the INSPIRATION-S trial, atorvastatin versus placebo was associated with a non-significant 16% reduction in 30-day composite of venous/arterial thrombosis or death ICU patients COVID-19. Thrombo-inflammatory response COVID-19 may last beyond first 30 days. Methods: This article reports effects 20 mg daily on 90-day clinical and functional outcomes from INSPIRATION-S, double-blind multicenter randomized trial adult The main outcome for this pre-specified study adjudicated...