A5101672840- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Wnt/β-catenin signaling in development and cancer
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Kruppel-like factors research
- Tuberculosis Research and Epidemiology
- Sarcoidosis and Beryllium Toxicity Research
- Intensive Care Unit Cognitive Disorders
- Inflammasome and immune disorders
- Mycobacterium research and diagnosis
- Synthesis and biological activity
- Infectious Encephalopathies and Encephalitis
- Dermatological diseases and infestations
- Iron Metabolism and Disorders
- Cancer-related gene regulation
- Kawasaki Disease and Coronary Complications
- Reproductive System and Pregnancy
- Pneumonia and Respiratory Infections
- Ovarian function and disorders
- Autoimmune and Inflammatory Disorders Research
- Extracellular vesicles in disease
Shahid Beheshti University of Medical Sciences
2019-2025
Masih Daneshvari Hospital
2019-2025
Ottawa Hospital
2020-2023
Ottawa Hospital Research Institute
2020-2023
Shaheed Rajaei Cardiovascular Medical and Research Center
2022
Weatherford College
2020
Université de Montréal
2015
Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.To evaluate effects intermediate-dose vs standard-dose prophylactic anticoagulation among COVID-19 admitted intensive care unit (ICU).Multicenter randomized trial a 2 × factorial design performed 10 academic centers Iran comparing (first hypothesis) and statin therapy matching placebo (second hypothesis; not this article) adult ICU Patients...
Microvascular and macrovascular thrombotic events are among the hallmarks of coronavirus disease 2019 (COVID-19). Furthermore, exuberant immune response is considered an important driver pulmonary extrapulmonary manifestations COVID-19. The optimal management strategy to prevent thrombosis in critically-ill patients with COVID-19 remains unknown.
Abstract Background Thrombotic complications are considered among the main extrapulmonary manifestations of coronavirus disease 2019 (COVID-19). The optimal type and duration prophylactic antithrombotic therapy in these patients remain unknown. Methods This article reports final (90-day) results Intermediate versus Standard-dose Prophylactic anticoagulation In cRitically-ill pATIents with COVID-19: An opeN label randomized controlled trial (INSPIRATION) study. Patients COVID-19 admitted to...
Abstract Objective To assess the effect of statin treatment versus placebo on clinical outcomes in patients with covid-19 admitted to intensive care unit (ICU). Design INSPIRATION/INSPIRATION-S was a multicenter, randomized controlled trial 2×2 factorial design. Results for anticoagulation randomization have been reported previously. double blind atorvastatin are here. Setting 11 hospitals Iran. Participants Adults aged ≥18 years ICU. Intervention Atorvastatin 20 mg orally once daily...
Whereas the roles of canonical wingless-type MMTV (mouse mammary tumor virus) integration site family (WNT) signaling pathway in regulation ovarian follicle growth and steroidogenesis are now established, noncanonical WNT ovary has been largely overlooked. Noncanonical WNTs, including WNT5a WNT11, expressed granulosa cells (GCs) differentially regulated throughout development, but their physiologic remain unknown. Using conditional gene targeting, we found that GC-specific inactivation Wnt5a...
Coronavirus disease 2019 (COVID-19) can be fatal in severe cases. Accordingly, predicting the severity and prognosis of is valuable. This study examined role electrolyte imbalances COVID-19. In this cross-sectional study, 169 hospitalized patients with COVID-19 were included categorized into three groups based on (moderate, severe, critical). Serum levels electrolytes (calcium [Ca], phosphorus [P], sodium [Na], potassium [k], magnesium [Mg]), inflammatory markers (D-dimer, C-reactive protein...
Abstract Colchicine has shown clinical benefits in the management of COVID‐19 via its anti‐inflammatory effect. However, exact role colchicine patients is unknown. The current trial was performed on 202 with moderate to severe COVID‐19. Patients were randomly assigned a 1:1 ratio receive up 3‐day course 0.5 mg followed by 12‐day 1 combination standard care or 15‐day care. Among randomized patients, 153 completed study and received colchicine/standard continued ( M age, 54.72 [ SD , 15.03]...
Abstract Background and Aim The efficacy of Sequential Organ Failure Assessment (SOFA) score as predictor clinical outcomes among ICU‐admitted COVID‐19 patients is still controversial. We aimed to assess whether SOFA‐score in different time intervals could predict 28‐day mortality compared with other well‐acknowledged risk factors mortality. Methods This observational prospective cohort was conducted on 1057 from March 2020 2022 at Masih Daneshvari Hospital, Iran. univariate multivariate Cox...
Abstract The ovarian surface epithelium (OSE) is a monolayer that covers the and involved in ovulation by rupturing enabling release of mature oocyte repairing wound after ovulation. Epithelial-to-mesenchymal transition (EMT) mechanism may promote healing While this process poorly understood OSE, other tissues repair known to be under control local microenvironment different growth factors such as WNT signaling pathway. Among family members, WNT4 WNT5a are expressed OSE critical for...
Background: Remdesivir is effective against SARS-Cov-2 with little evidence of its adverse effect on the cardiac system. The aim present study investigating incidence bradycardia in COVID-19 patients treated Remdesivir. Methods: This prospective longitudinal was conducted a tertiary center for therapy. objectives were to investigate sinus bradycardia, and also association between their demographics, underlying diseases, disease severity developing Results: Of 177 patients, 44% male. mean...
Background In the INSPIRATION-S trial, atorvastatin versus placebo was associated with a nonsignificant 16% reduction in 30-day composite of venous/arterial thrombosis or death intensive care unit (ICU) patients COVID-19. Thrombo-inflammatory response coronavirus disease 2019 (COVID-19) may last beyond first 30 days. Methods This article reports effects 20 mg daily on 90-day clinical and functional outcomes from INSPIRATION-S, double-blind multicenter randomized trial adult ICU The main...
Background The sudden outbreak of the COVID-19 disease originated in Wuhan, China, December 2019. There have been few reports clinical course disease, but detailed information on risk factors for increased hospital stay and mortality is not available. In this study, we aimed to present details 53 confirmed cases share longer death. Methods enrolled fifty-three patients with infection from a referral academic Tehran, Iran admitted between March April 2020. Patients' demographics, laboratory...
Abstract Polycystic ovarian syndrome (PCOS) is a complex multi-factorial associated with androgen excess and anovulatory infertility. In the current study, we investigated role of dihydrotestosterone-induced exosomal miR-379-5p release in determining destiny developing follicles. Our hypothesis was that regulates granulosa cell content by facilitating its follicular-stage dependent manner, process which determines fate. Compared to human non-PCOS subjects, individuals PCOS exhibit higher...
Sir, At present, the novel coronavirus disease (COVID-19), a contagious and pandemic that leads to mortality, is significant global concern. The exact cause of enormous inflammation induced by severe acute respiratory syndrome 2 (SARS-CoV-2) unclear. Nonetheless, p38 mitogen-activated protein kinase (MAPK) system one precise pathways have been previously implicated in animal models lung injury myocardial injury.[1] For replication purposes, SARS-CoV-2, like other RNA viruses, may precisely...
Backgrounds: In the INSPIRATION-S trial, atorvastatin versus placebo was associated with a non-significant 16% reduction in 30-day composite of venous/arterial thrombosis or death ICU patients COVID-19. Thrombo-inflammatory response COVID-19 may last beyond first 30 days. Methods: This article reports effects 20 mg daily on 90-day clinical and functional outcomes from INSPIRATION-S, double-blind multicenter randomized trial adult The main outcome for this pre-specified study adjudicated...
Background: Determination of a desirable diagnostic tests is an issue importance especially to differentiate between tuberculosis) TB(, sarcoidosis, and anthracosis. The purpose the present study was determine differential diagnosis tuberculosis, sarcoidosis anthracosis with CD8, CD3, CD4 by flow-cytometry. Materials Methods: In this descriptive cross-sectional comparative survey, 40 consecutive patients attending Masih Daneshvari Hospital in Tehran were enrolled CD4/CD8 ratio, determined...
Background: Tuberculosis (TB) and sarcoidosis are two chronic, systemic, granulomatous diseases that have similar pulmonary extrapulmonary manifestations. Given the similarities between diseases, it is suggested Mycobacterium genome may play a role in sarcoidosis. Identification of species isolated from patients optimizes treatment process patients. The present study investigates biopsy tissue samples with for presence tissues. Methods: This descriptive cross-sectional was performed on all...
Dear Editor, In December 2019, novel coronavirus (SARS-CoV-2) pneumonia started to spread in the entire world and is causing growing concerns medical community as virus continues globally. Up September 22, 2020, 31,485,162 cases were diagnosed SARS-CoV-2 positive 969,298 died. absence of effective treatment for COVID-19, there an urgent need identify alternative therapies control this pandemic. Several agents such chloroquine, hydroxychloroquine, antivirals, intravenous immunoglobulins,...